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Development of the pharmacological post conditioning via positive inotropics and elucidation of the intracellular mechanism

Research Project

Project/Area Number 21791452
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Anesthesiology/Resuscitation studies
Research InstitutionNagasaki University

Principal Investigator

HIGASHIJIMA Ushio  長崎大学, 大学院・医歯薬学総合研究科, 助教 (20380909)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords周術期管理学 / 薬理学的ポストコンディショニング / 強心薬 / 循環器・高血圧 / 薬剤反応性 / ミトコンドリアATP感受性カリウムチャネル / プロテインキナーゼC / PDEIII阻害薬 / カルシウムセンシタイザー
Research Abstract

The present study was carried out to determined whether two inotropics(milrinone and levosimendan), which have positive inotropic effects despite different mechanisms, exert cardioprotective effects and to elucidate their intracellular mechanisms. Both milrinone and levosimendan significantly decreased the myocardial infarct size after ischemic stimulus significantly. Phosphatidylinositol-3-kinase and nitric oxide were common mediators for the cardioprotection of these drugs. Protein kinase C, cyclooxygenase 2, and mitochondrial ATP sensitive potassium channels played crucial roles in levosimendan-induced cardioprotection.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (9 results)

All 2011 2010 2009 Other

All Presentation (9 results)

  • [Presentation] Levosimendan- but not milrinone-induced postconditioning is dependent on cyclooxygenase-2 in rat hearts2011

    • Author(s)
      東島潮
    • Organizer
      アメリカ麻酔学会
    • Place of Presentation
      シカゴ
    • Year and Date
      2011-10-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Levosimendan-but not milrinone-induced postconditioning is dependent on cyclooxygenase-2 in rat hearts2011

    • Organizer
      アメリカ麻酔学会
    • Related Report
      2011 Final Research Report
  • [Presentation] The role of protein kinase C in milrinone- and levosimendan-induced postconditioning in rat hearts.2010

    • Author(s)
      東島潮
    • Organizer
      アメリカ麻酔学会
    • Place of Presentation
      アメリカ合衆国・サンディエゴ
    • Year and Date
      2010-10-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] ミルリノンおよびレボシメンダンによる薬理学的ポストコンディショニングの検討とその分子機序の解析2010

    • Author(s)
      東島潮
    • Organizer
      日本循環制御医学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-05-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] The role of protein kinase C in milrinone-and levosimendan-induced postconditioning rat hearts2010

    • Organizer
      アメリカ麻酔学会
    • Related Report
      2011 Final Research Report
  • [Presentation] Differential Mechanisms of Milrinone-and Levosimendan-Induced Postconditioning in Rat Hearts2009

    • Author(s)
      東島潮
    • Organizer
      米国麻酔学会
    • Place of Presentation
      ニューオリンズ
    • Year and Date
      2009-10-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] A role for the mitochondrial KATP channel in postconditioning induced by milrinone or levosimendan in rat hearts2009

    • Organizer
      アメリカ麻酔学会
    • Related Report
      2011 Final Research Report
  • [Presentation] ミルリノンおよびレボシメンダンによる薬理学的ポストコンディショニングの検討とその分子機序の解明

    • Organizer
      第31回日本循環制御医学会総会
    • Related Report
      2011 Final Research Report
  • [Presentation] 強心薬(ミルリノン、レボシメンダン)による薬理学的ポストコンディショニングの分子機序の解明~シクロオキシゲナーゼ2の役割~

    • Organizer
      第32回日本循環制御医学会総会
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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