Development of the pharmacological post conditioning via positive inotropics and elucidation of the intracellular mechanism
| Project/Area Number |
21791452
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nagasaki University |
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Principal Investigator |
HIGASHIJIMA Ushio 長崎大学, 大学院・医歯薬学総合研究科, 助教 (20380909)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 周術期管理学 / 薬理学的ポストコンディショニング / 強心薬 / 循環器・高血圧 / 薬剤反応性 / ミトコンドリアATP感受性カリウムチャネル / プロテインキナーゼC / PDEIII阻害薬 / カルシウムセンシタイザー |
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| Research Abstract |
The present study was carried out to determined whether two inotropics(milrinone and levosimendan), which have positive inotropic effects despite different mechanisms, exert cardioprotective effects and to elucidate their intracellular mechanisms. Both milrinone and levosimendan significantly decreased the myocardial infarct size after ischemic stimulus significantly. Phosphatidylinositol-3-kinase and nitric oxide were common mediators for the cardioprotection of these drugs. Protein kinase C, cyclooxygenase 2, and mitochondrial ATP sensitive potassium channels played crucial roles in levosimendan-induced cardioprotection.
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Report
(4 results)
Research Products
(9 results)
