| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
The present study was carried out to determined whether two inotropics(milrinone and levosimendan), which have positive inotropic effects despite different mechanisms, exert cardioprotective effects and to elucidate their intracellular mechanisms. Both milrinone and levosimendan significantly decreased the myocardial infarct size after ischemic stimulus significantly. Phosphatidylinositol-3-kinase and nitric oxide were common mediators for the cardioprotection of these drugs. Protein kinase C, cyclooxygenase 2, and mitochondrial ATP sensitive potassium channels played crucial roles in levosimendan-induced cardioprotection.
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