• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of new bio-markers as a prognostic factor in localized prostate cancer patients

Research Project

Project/Area Number 21791488
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionChiba University

Principal Investigator

IMAMOTO Takashi  千葉大学, 医学部・附属病院, 講師 (20375629)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords腫瘍学 / 前立腺癌 / 根治的前立腺全摘除術 / 術後再発予測 / 遺伝子・蛋白マーカー
Research Abstract

Previous reports have indicated that up to 43% of men with prostate cancer will show an upgraded Gleason score from biopsy to radical prostatectomy (RP). A preparative nomogram was developed at the University of Hamburg to predict the probability of upgrading from biopsy to RP specimen. From two Japanese institutions, clinical and pathologic data of 503 patients were supplied for validation. Nomogram predictions of upgrading were not within 10% of an ideal nomogram. The Hamburg nomogram seems to provide reasonably accurate predictions regardless of minor variations in pathological assessment, but is not necessarily so accurate when applied to Japanese patient populations.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (31 results)

All 2011 2010 2009

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (7 results) Book (7 results)

  • [Journal Article] Development and external validation of a nomogram predicting the probability of significant Gleason sum upgrading among Japanese patients with localized prostate cancer2011

    • Author(s)
      Imamoto T, Utsumi T, Takano M, Komaru A, Fukasawa S, Suyama T, Kawamura K, Kamiya N, Miura J, Suzuki H, Ueda T, Ichikawa T
    • Journal Title

      2011. Prostate Cancer

      Pages: 754382-754382

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Complications, urinary continence, and oncologic outcomes of laparoscopic radical prostatectomy: single-surgeon experience for the first 100 cases2011

    • Author(s)
      Imamoto T, Goto Y, Utsumi T, Fuse M, Kawamura K, Kamiya N, Naya Y, Suzuki H, Kondo Y, Ichikawa T
    • Journal Title

      2011. Prostate Cancer

      Pages: 606505-606505

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Significance of serum osteoprotegerin and receptor activator of nuclear factor κB ligand in Japanese prostate cancer patients with bone metastasis2011

    • Author(s)
      Kamiya N, Suzuki H, Endo T, Takano M, Yano M, Naoi M, Kawamura K, Imamoto T, Takanami M, Ichikawa T
    • Journal Title

      Int J Clin Oncol

      Volume: 16 Pages: 366-372

    • NAID

      10029527657

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Significance of serum osteoprotegerin and receptor activator of nuclear factor kB ligand in Japanese prostate cancer patients with bone metastasis2011

    • Author(s)
      Kamiya N, Suzuki H, Endo T, Takano M, Yano M, Naoi M, Kawamura K, Imamoto T, Takanami M, Ichikawa T
    • Journal Title

      Int J Clin Oncol

      Volume: 16 Issue: 4 Pages: 366-372

    • DOI

      10.1007/s10147-011-0193-7

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development and external validation of a nomogram predicting the probability of significant Gleason sum upgrading among Japanese patients with localized prostate cancer2011

    • Author(s)
      Imamoto T, Utsumi T, Takano M, Komaru A, Fukasawa S, Suyama T, Kawamura K, Kamiya N, Miura J, Suzuki H, Ueda T, Ichikawa T
    • Journal Title

      Prostate Cancer

      Volume: 2011 Pages: 754382-754382

    • DOI

      10.1155/2011/754382

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complications, urinary continence, and oncologic outcomes of laparoscopic radical prostatectomy : single-surgeon experience for the first 100 cases2011

    • Author(s)
      Imamoto T, Groto Y, Naya Y, et al
    • Journal Title

      Prostate Cancer

      Volume: 2011 Pages: 606505-606505

    • DOI

      10.1155/2011/606505

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] External validation of a nomogram predicting the probability of prostate cancer Gleason sum upgrading between biopsy and radical prostatectomy pathology among Japanese patients2010

    • Author(s)
      Imamoto T, Suzuki H, Utsumi T, Takano M, Suyama T, Kawamura K, Kamiya N, Naya Y, Ueda T, Ichikawa T
    • Journal Title

      Urology

      Volume: 76 Pages: 404-410

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Implications of body mass index in Japanese patients with prostate cancer who had undergone radical prostatectomy2010

    • Author(s)
      Komaru A, Kamiya N, Suzuki H, Endo T, Takano M, Yano M, Kawamura K, Imamoto T, Ichikawa T
    • Journal Title

      Jpn J Clin Oncol

      Volume: 40 Pages: 353-359

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Implications of serum bone turnover markers in prostate cancer patients with bone metastasis2010

    • Author(s)
      Kamiya N, Suzuki H, Yano M, Endo T, Takano M, Komaru A, Kawamura K, Sekita N, Imamoto T, Ichikawa T
    • Journal Title

      Urology

      Volume: 75 Pages: 1446-1451

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Implications of body mass index in Japanese patients with prostate cancer who had undergone radical prostatectomy.2010

    • Author(s)
      Komaru A, Kamiya N, Suzuki H, Endo T, Takano M, Yano M, Kawamura K, Imamoto T, Ichikawa T.
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 40 Pages: 353-359

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Implications of serum bone turnover markers in prostate cancer patients with bone metastasis.2010

    • Author(s)
      Kamiya N, Suzuki H, Yano M, Endo T, Takano M, Komaru A, Kawamura K, Sekita N, Imamoto T, Ichikawa T.
    • Journal Title

      Urology.

      Volume: 75 Pages: 1446-1451

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] External validation of a nomogram predicting the probability of prostate cancer Gleason sum upgrading between biopsy and radical prostatectomy pathology among Japanese patients.2010

    • Author(s)
      Imamoto T, Suzuki H, Utsumi T, Takano M, Suyama T, Kawamura K, Kamiya N, Naya Y, Ueda T, Ichikawa T.
    • Journal Title

      Urology.

      Volume: 76 Pages: 404-410

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Does presence of prostate cancer affect serum testosterone levels in clinically localized prostate cancer patients?2009

    • Author(s)
      Imamoto T, Suzuki H, Yano M, Kawamura K, Kamiya N, Araki K, Komiya A, Naya Y, Shiraishi T, Ichikawa T
    • Journal Title

      Prostate Cancer Prostatic Dis

      Volume: 12 Pages: 78-82

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The isolation and identification of apolipoprotein C-I in hormone-refractory prostate cancer using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry2009

    • Author(s)
      Yamamoto-Ishikawa K, Suzuki H, Nezu M, Kamiya N, Imamoto T, Komiya A, Sogawa K, Tomonaga T, Nomura F, Ichikawa T
    • Journal Title

      Asian J Androl

      Volume: 11 Pages: 299-307

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Does presence of prostate cancer affect serum testosterone levels in clinically localized prostate cancer patients?2009

    • Author(s)
      Imamoto T, Suzuki H, Yano M, Kawamura K, Kamiya N, Araki K, Komiya A, Naya Y, Shiraishi T, Ichikawa T.
    • Journal Title

      Prostate Cancer Prostatic Dis. 12

      Pages: 78-82

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The isolation and identification of apolipoprotein C-I in hormone-refractory prostate cancer using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry2009

    • Author(s)
      Yamamoto-Ishikawa K, Suzuki H, Nezu M, Komiya N, Imamoto T, Komiya A, Sogawa K, Tomonaga T, Nomura F, Ichikawa T.
    • Journal Title

      Asian J Androl. 11

      Pages: 299-307

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] External validation and head-to-head comparison of Japanese and Western prostate biopsy nomograms using Japanese data sets2009

    • Author(s)
      Utsumi T, Kawamura K, Suzuki H, Kamiya N, Imamoto T, Miura J, Ueda T, Maruoka M, Sekita N, Mikami K, Ichikawa T.
    • Journal Title

      Int J Urol. 16

      Pages: 416-419

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] シンポジウム2前立腺:発癌・増殖:ホルモンとの接点.前立腺癌と血中アンドロゲン2011

    • Author(s)
      今本敬, 内海孝信, 佐塚智和, 柳澤充, 矢野仁, 川村幸治, 神谷直人, 二瓶直樹, 鈴木啓悦, 市川智彦
    • Organizer
      日本アンドロロジー学会第30回学術大会
    • Place of Presentation
      東京都
    • Year and Date
      2011-07-23
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] シンポジウム内分泌療法の現状と課題.前立腺癌に対する内分泌療法:現状と課題2011

    • Author(s)
      今本敬, 内海孝信, 柳澤充, 川村幸治, 二瓶直樹, 市川智彦
    • Organizer
      第11回関東ホルモンと癌研究会
    • Place of Presentation
      東京都
    • Year and Date
      2011-01-29
    • Related Report
      2011 Final Research Report
  • [Presentation] モーニングセミナー テストステロンと前立腺.テストステロンはがんのバイオマーカーか?2010

    • Author(s)
      今本敬, 内海孝信, 高野慎, 柳澤充, 矢野仁, 川村幸治, 神谷直人, 二瓶直樹, 鈴木啓悦, 市川智彦
    • Organizer
      第10回日本Men's Health医学会
    • Place of Presentation
      東京都
    • Year and Date
      2010-11-27
    • Related Report
      2011 Final Research Report
  • [Presentation] テストステロンと前立腺.テストステロンはがんのバイオマーカーか?2010

    • Author(s)
      今本敬、内海孝信、高野慎、柳澤充、矢野仁、川村幸治、神谷直人、二瓶直樹、鈴木啓悦、市川智彦
    • Organizer
      第10回日本Men's Health医学会(Men's Health Week2010)
    • Place of Presentation
      東京都
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腹腔鏡下前立腺全摘除術2009

    • Author(s)
      今本敬, 遠藤匠, 高野慎, 矢野仁, 川村幸治, 神谷直人, 納谷幸男, 鈴木啓悦, 市川智彦
    • Organizer
      第12回泌尿器腹腔鏡ワークショップ第23回日本Endourology・ESWL学会総会
    • Place of Presentation
      東京都
    • Year and Date
      2009-11-11
    • Related Report
      2011 Final Research Report
  • [Presentation] 腹腔鏡下前立腺全摘除術.第12回泌尿器腹腔鏡ワークショップ2009

    • Author(s)
      今本敬, 遠藤匠、高野慎、矢野仁、川村幸治、神谷直人、納谷幸男、鈴木啓悦, 市川智彦
    • Organizer
      第23回日本Endourology・ESWL学会総会
    • Place of Presentation
      東京都
    • Year and Date
      2009-11-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] JUAアップデートセッションパネルディスカッション6.内分泌・生殖機能・性機能領域:前立腺癌ホルモン療法後の低アンドロゲン症2009

    • Author(s)
      今本敬, 鈴木啓悦, 内海孝信, 高野慎, 川村幸治, 神谷直人, 納谷幸男, 市川智彦, 小島聡子, 古谷雄三, 佐藤直秀
    • Organizer
      第97回日本泌尿器科学会総会
    • Place of Presentation
      岡山県
    • Year and Date
      2009-04-19
    • Related Report
      2011 Final Research Report
  • [Book] 前立腺癌に対するアンドロゲン除去療法2011

    • Author(s)
      今本敬, 市川智彦
    • Publisher
      メジカルビュー社,東京
    • Related Report
      2011 Final Research Report
  • [Book] 第3版前立腺癌のすべて-基礎から最新治療まで-2011

    • Author(s)
      今本敬
    • Publisher
      メジカルビュー社,東京
    • Related Report
      2011 Final Research Report
  • [Book] 前立腺癌に対するアンドロゲン除去療法.VII.腫瘍.泌尿器科薬物療法1st VISIT, 2nd VISIT2011

    • Author(s)
      今本敬, 市川智彦
    • Total Pages
      5
    • Publisher
      メジカルビュー社
    • Related Report
      2011 Annual Research Report
  • [Book] 前立腺癌診療-こんなときどうするQ & A2010

    • Author(s)
      神谷直人, 鈴木啓悦, 今本敬, 川村幸治, 市川智彦
    • Publisher
      中外医学社,東京
    • Related Report
      2011 Final Research Report
  • [Book] ホルモン抵抗性前立腺癌(HRPC)の発生機序について教えてください.前立腺癌診療-こんなときどうするQ&A2010

    • Author(s)
      神谷直人, 鈴木啓悦, 今本敬, 川村幸治、市川智彦
    • Total Pages
      5
    • Publisher
      中外医学社
    • Related Report
      2010 Annual Research Report
  • [Book] 前立腺癌の発生リスク・治療とアンドロゲン2009

    • Author(s)
      今本敬, 鈴木啓悦, 市川智彦
    • Publisher
      中外医学社,東京
    • Related Report
      2011 Final Research Report
  • [Book] Annual Review 糖尿病・代謝・内分泌.前立腺癌の発生リスク・治療とアンドロゲン2009

    • Author(s)
      今本敬、鈴木啓悦、市川智彦
    • Total Pages
      254
    • Publisher
      中外医学社
    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi