Development of new bio-markers as a prognostic factor in localized prostate cancer patients

• Project/Area Number: 21791488
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Chiba University
• Principal Investigator: IMAMOTO Takashi 千葉大学, 医学部・附属病院, 講師 (20375629)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 腫瘍学 / 前立腺癌 / 根治的前立腺全摘除術 / 術後再発予測 / 遺伝子・蛋白マーカー

Research Abstract

Previous reports have indicated that up to 43% of men with prostate cancer will show an upgraded Gleason score from biopsy to radical prostatectomy (RP). A preparative nomogram was developed at the University of Hamburg to predict the probability of upgrading from biopsy to RP specimen. From two Japanese institutions, clinical and pathologic data of 503 patients were supplied for validation. Nomogram predictions of upgrading were not within 10% of an ideal nomogram. The Hamburg nomogram seems to provide reasonably accurate predictions regardless of minor variations in pathological assessment, but is not necessarily so accurate when applied to Japanese patient populations.

Research Products

• [Journal Article] Development and external validation of a nomogram predicting the probability of significant Gleason sum upgrading among Japanese patients with localized prostate cancer (2011)
  • Author(s): Imamoto T, Utsumi T, Takano M, Komaru A, Fukasawa S, Suyama T, Kawamura K, Kamiya N, Miura J, Suzuki H, Ueda T, Ichikawa T
  • Journal Title: 2011. Prostate Cancer Pages: 754382-754382
  • Peer Reviewed
• [Journal Article] Complications, urinary continence, and oncologic outcomes of laparoscopic radical prostatectomy: single-surgeon experience for the first 100 cases (2011)
  • Author(s): Imamoto T, Goto Y, Utsumi T, Fuse M, Kawamura K, Kamiya N, Naya Y, Suzuki H, Kondo Y, Ichikawa T
  • Journal Title: 2011. Prostate Cancer Pages: 606505-606505
  • Peer Reviewed
• [Journal Article] Significance of serum osteoprotegerin and receptor activator of nuclear factor κB ligand in Japanese prostate cancer patients with bone metastasis (2011)
  • Author(s): Kamiya N, Suzuki H, Endo T, Takano M, Yano M, Naoi M, Kawamura K, Imamoto T, Takanami M, Ichikawa T
  • Journal Title: Int J Clin Oncol Volume: 16 Pages: 366-372
  • NAID: 10029527657
  • Peer Reviewed
• [Journal Article] Significance of serum osteoprotegerin and receptor activator of nuclear factor kB ligand in Japanese prostate cancer patients with bone metastasis (2011)
  • Author(s): Kamiya N, Suzuki H, Endo T, Takano M, Yano M, Naoi M, Kawamura K, Imamoto T, Takanami M, Ichikawa T
  • Journal Title: Int J Clin Oncol Volume: 16 Pages: 366-372
  • DOI: 10.1007/s10147-011-0193-7
  • Peer Reviewed
• [Journal Article] Development and external validation of a nomogram predicting the probability of significant Gleason sum upgrading among Japanese patients with localized prostate cancer (2011)
  • Author(s): Imamoto T, Utsumi T, Takano M, Komaru A, Fukasawa S, Suyama T, Kawamura K, Kamiya N, Miura J, Suzuki H, Ueda T, Ichikawa T
  • Journal Title: Prostate Cancer Volume: 2011 Pages: 754382-754382
  • DOI: 10.1155/2011/754382
  • Peer Reviewed
• [Journal Article] Complications, urinary continence, and oncologic outcomes of laparoscopic radical prostatectomy : single-surgeon experience for the first 100 cases (2011)
  • Author(s): Imamoto T, Groto Y, Naya Y, et al
  • Journal Title: Prostate Cancer Volume: 2011 Pages: 606505-606505
  • DOI: 10.1155/2011/606505
  • Peer Reviewed
• [Journal Article] External validation of a nomogram predicting the probability of prostate cancer Gleason sum upgrading between biopsy and radical prostatectomy pathology among Japanese patients (2010)
  • Author(s): Imamoto T, Suzuki H, Utsumi T, Takano M, Suyama T, Kawamura K, Kamiya N, Naya Y, Ueda T, Ichikawa T
  • Journal Title: Urology Volume: 76 Pages: 404-410
  • Peer Reviewed
• [Journal Article] Implications of body mass index in Japanese patients with prostate cancer who had undergone radical prostatectomy (2010)
  • Author(s): Komaru A, Kamiya N, Suzuki H, Endo T, Takano M, Yano M, Kawamura K, Imamoto T, Ichikawa T
  • Journal Title: Jpn J Clin Oncol Volume: 40 Pages: 353-359
  • Peer Reviewed
• [Journal Article] Implications of serum bone turnover markers in prostate cancer patients with bone metastasis (2010)
  • Author(s): Kamiya N, Suzuki H, Yano M, Endo T, Takano M, Komaru A, Kawamura K, Sekita N, Imamoto T, Ichikawa T
  • Journal Title: Urology Volume: 75 Pages: 1446-1451
  • Peer Reviewed
• [Journal Article] Implications of body mass index in Japanese patients with prostate cancer who had undergone radical prostatectomy. (2010)
  • Author(s): Komaru A, Kamiya N, Suzuki H, Endo T, Takano M, Yano M, Kawamura K, Imamoto T, Ichikawa T.
  • Journal Title: Jpn J Clin Oncol. Volume: 40 Pages: 353-359
  • Peer Reviewed
• [Journal Article] Implications of serum bone turnover markers in prostate cancer patients with bone metastasis. (2010)
  • Author(s): Kamiya N, Suzuki H, Yano M, Endo T, Takano M, Komaru A, Kawamura K, Sekita N, Imamoto T, Ichikawa T.
  • Journal Title: Urology. Volume: 75 Pages: 1446-1451
  • Peer Reviewed
• [Journal Article] External validation of a nomogram predicting the probability of prostate cancer Gleason sum upgrading between biopsy and radical prostatectomy pathology among Japanese patients. (2010)
  • Author(s): Imamoto T, Suzuki H, Utsumi T, Takano M, Suyama T, Kawamura K, Kamiya N, Naya Y, Ueda T, Ichikawa T.
  • Journal Title: Urology. Volume: 76 Pages: 404-410
  • Peer Reviewed
• [Journal Article] Does presence of prostate cancer affect serum testosterone levels in clinically localized prostate cancer patients? (2009)
  • Author(s): Imamoto T, Suzuki H, Yano M, Kawamura K, Kamiya N, Araki K, Komiya A, Naya Y, Shiraishi T, Ichikawa T
  • Journal Title: Prostate Cancer Prostatic Dis Volume: 12 Pages: 78-82
  • Peer Reviewed
• [Journal Article] The isolation and identification of apolipoprotein C-I in hormone-refractory prostate cancer using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (2009)
  • Author(s): Yamamoto-Ishikawa K, Suzuki H, Nezu M, Kamiya N, Imamoto T, Komiya A, Sogawa K, Tomonaga T, Nomura F, Ichikawa T
  • Journal Title: Asian J Androl Volume: 11 Pages: 299-307
  • Peer Reviewed
• [Journal Article] Does presence of prostate cancer affect serum testosterone levels in clinically localized prostate cancer patients? (2009)
  • Author(s): Imamoto T, Suzuki H, Yano M, Kawamura K, Kamiya N, Araki K, Komiya A, Naya Y, Shiraishi T, Ichikawa T.
  • Journal Title: Prostate Cancer Prostatic Dis. 12 Pages: 78-82
  • Peer Reviewed
• [Journal Article] The isolation and identification of apolipoprotein C-I in hormone-refractory prostate cancer using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (2009)
  • Author(s): Yamamoto-Ishikawa K, Suzuki H, Nezu M, Komiya N, Imamoto T, Komiya A, Sogawa K, Tomonaga T, Nomura F, Ichikawa T.
  • Journal Title: Asian J Androl. 11 Pages: 299-307
  • Peer Reviewed
• [Journal Article] External validation and head-to-head comparison of Japanese and Western prostate biopsy nomograms using Japanese data sets (2009)
  • Author(s): Utsumi T, Kawamura K, Suzuki H, Kamiya N, Imamoto T, Miura J, Ueda T, Maruoka M, Sekita N, Mikami K, Ichikawa T.
  • Journal Title: Int J Urol. 16 Pages: 416-419
  • Peer Reviewed
• [Presentation] シンポジウム2前立腺:発癌・増殖:ホルモンとの接点.前立腺癌と血中アンドロゲン (2011)
  • Author(s): 今本敬, 内海孝信, 佐塚智和, 柳澤充, 矢野仁, 川村幸治, 神谷直人, 二瓶直樹, 鈴木啓悦, 市川智彦
  • Organizer: 日本アンドロロジー学会第30回学術大会
  • Place of Presentation: 東京都
  • Year and Date: 2011-07-23
• [Presentation] シンポジウム内分泌療法の現状と課題.前立腺癌に対する内分泌療法:現状と課題 (2011)
  • Author(s): 今本敬, 内海孝信, 柳澤充, 川村幸治, 二瓶直樹, 市川智彦
  • Organizer: 第11回関東ホルモンと癌研究会
  • Place of Presentation: 東京都
  • Year and Date: 2011-01-29
• [Presentation] モーニングセミナー テストステロンと前立腺.テストステロンはがんのバイオマーカーか? (2010)
  • Author(s): 今本敬, 内海孝信, 高野慎, 柳澤充, 矢野仁, 川村幸治, 神谷直人, 二瓶直樹, 鈴木啓悦, 市川智彦
  • Organizer: 第10回日本Men's Health医学会
  • Place of Presentation: 東京都
  • Year and Date: 2010-11-27
• [Presentation] テストステロンと前立腺.テストステロンはがんのバイオマーカーか? (2010)
  • Author(s): 今本敬、内海孝信、高野慎、柳澤充、矢野仁、川村幸治、神谷直人、二瓶直樹、鈴木啓悦、市川智彦
  • Organizer: 第10回日本Men's Health医学会(Men's Health Week2010)
  • Place of Presentation: 東京都
  • Year and Date: 2010-11-27
• [Presentation] 腹腔鏡下前立腺全摘除術 (2009)
  • Author(s): 今本敬, 遠藤匠, 高野慎, 矢野仁, 川村幸治, 神谷直人, 納谷幸男, 鈴木啓悦, 市川智彦
  • Organizer: 第12回泌尿器腹腔鏡ワークショップ第23回日本Endourology・ESWL学会総会
  • Place of Presentation: 東京都
  • Year and Date: 2009-11-11
• [Presentation] 腹腔鏡下前立腺全摘除術.第12回泌尿器腹腔鏡ワークショップ (2009)
  • Author(s): 今本敬, 遠藤匠、高野慎、矢野仁、川村幸治、神谷直人、納谷幸男、鈴木啓悦, 市川智彦
  • Organizer: 第23回日本Endourology・ESWL学会総会
  • Place of Presentation: 東京都
  • Year and Date: 2009-11-11
• [Presentation] JUAアップデートセッションパネルディスカッション6.内分泌・生殖機能・性機能領域:前立腺癌ホルモン療法後の低アンドロゲン症 (2009)
  • Author(s): 今本敬, 鈴木啓悦, 内海孝信, 高野慎, 川村幸治, 神谷直人, 納谷幸男, 市川智彦, 小島聡子, 古谷雄三, 佐藤直秀
  • Organizer: 第97回日本泌尿器科学会総会
  • Place of Presentation: 岡山県
  • Year and Date: 2009-04-19
• [Book] 前立腺癌に対するアンドロゲン除去療法 (2011)
  • Author(s): 今本敬, 市川智彦
  • Publisher: メジカルビュー社,東京
• [Book] 第3版前立腺癌のすべて-基礎から最新治療まで- (2011)
  • Author(s): 今本敬
  • Publisher: メジカルビュー社,東京
• [Book] 前立腺癌に対するアンドロゲン除去療法.VII.腫瘍.泌尿器科薬物療法1st VISIT, 2nd VISIT (2011)
  • Author(s): 今本敬, 市川智彦
  • Total Pages: 5
  • Publisher: メジカルビュー社
• [Book] 前立腺癌診療-こんなときどうするQ & A (2010)
  • Author(s): 神谷直人, 鈴木啓悦, 今本敬, 川村幸治, 市川智彦
  • Publisher: 中外医学社,東京
• [Book] ホルモン抵抗性前立腺癌(HRPC)の発生機序について教えてください.前立腺癌診療-こんなときどうするQ&A (2010)
  • Author(s): 神谷直人, 鈴木啓悦, 今本敬, 川村幸治、市川智彦
  • Total Pages: 5
  • Publisher: 中外医学社
• [Book] 前立腺癌の発生リスク・治療とアンドロゲン (2009)
  • Author(s): 今本敬, 鈴木啓悦, 市川智彦
  • Publisher: 中外医学社,東京
• [Book] Annual Review 糖尿病・代謝・内分泌.前立腺癌の発生リスク・治療とアンドロゲン (2009)
  • Author(s): 今本敬、鈴木啓悦、市川智彦
  • Total Pages: 254
  • Publisher: 中外医学社