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The involvement of testosterone in ras model animal of invasive bladder cancer

Research Project

Project/Area Number 21791531
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionTeikyo University

Principal Investigator

ISOTANI Shuuji  帝京大学, 医学部, 講師 (70398741)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords膀胱癌 / ras / テストステロン / Hras / 化学発癌
Research Abstract

I evaluated the usefulness of rasH2 with human c-Ha-ras proto-oncogene as the animal model of muscle-invasive bladder cancer. I administered 0.05% BBN for 20 weeks. Although there are no significant differences in the incidence of all bladder cancer, as far as the incidence of bladder invasive cancer is concerned, rasH2 has the higher frequency compared with WT. The mean survival time of rasH2(23.3 weeks) was significantly shorter compared with WT(24.3 weeks). Consequently, rasH2 is a high susceptibility to bladder chemical carcinogenesis with the use of BBN. In particular, this study indicated the usefulness of rasH2 as model animals of invasive bladder cancer.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (4 results)

All 2012 2011 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] ヒトプロト型H-rasトランスジェニックマウスrasH2は浸潤性膀胱癌モデル動物である2012

    • Author(s)
      Jingsong yu
    • Journal Title

      帝京医学雑誌

      Volume: 35 Pages: 37-46

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] ヒトプロト型H-rasトランスジェニックマウスrasH2に対するBBN膀胱発癌2011

    • Author(s)
      武藤智、磯谷周治、堀江重郎
    • Organizer
      第15回日本がん分子標的治療学会学術集会
    • Year and Date
      2011-06-23
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒトプロト型H-rasトランスジェニックマウスrasH2に対するBBN膀胱発癌2010

    • Author(s)
      磯谷周治
    • Organizer
      第98回日本泌尿器科学会総会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-04-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒトプロト型H-rasトランスジェニックマウスrasH2に対するBBN膀胱発癌2010

    • Author(s)
      于松、陸彦、木村美恵、磯谷周治、井手久満、武藤智、堀江重郎
    • Organizer
      第98回日本泌尿器科学会総会
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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