Effect of Topical Application of Dexamethasone to the Round Window for inner ear circulation disorder and inflammation of the inner ear
Project/Area Number |
21791610
|
Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Otorhinolaryngology
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Research Institution | Nagoya University |
Principal Investigator |
OTAKE Hironao 名古屋大学, 医学部附属病院, 助教 (30508891)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
Keywords | 耳科学 / 内耳血流 / 虚血・再灌流障害 / アポトーシス / 虚血再灌流障害 / ステロイド / レーザードップラー / 虚血・再灌流 |
Research Abstract |
No significant change in CBF was observed after topical application of dexamethasone, neither did it affect the decrease in CBF caused by AICA occlusion. However, recovery of CBF after release of the AICA clamp was better in animals treated with dexamethasone than in those that did not receive dexamethasone. Topical application of dexamethasone may support autoregulation of cochlear blood flow(CBF) though it had no direct effect on CBF. Also, as for the hazardousness, it was not found by an intratympanic steroid, rather the steroid functioned protectively. In ischemic-reperfusion injury thought to be one of the causes of the sudden deafness, it followed that we could expect a constant effect.
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Report
(4 results)
Research Products
(22 results)