Elucidation of the carcinogenesis mechanism in a precancerous lesion and the extension of squamous cell carcinoma of the head and neck region
Project/Area Number |
21791649
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Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Otorhinolaryngology
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Research Institution | Tokyo Medical University |
Principal Investigator |
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 頭頸部外科学 / 頭頸部 / 前癌病変 / 癌抑制遺伝子 / 癌遺伝子 / 頭頸部癌 / EGFR / Cyclin D1 / 扁平上皮癌 / 癌化 |
Research Abstract |
We employed histopathological techniques to examine prognostic factors in the mechanism of carcinogenesis as well as extension in squamous cell carcinoma of the head and neck region, using a specimen of a precancerous lesion. For laryngeal and lingual precancerous lesions, decreased expression of cancer-restraining gene FHIT and increased expression of protein EGFR were found to be useful as indices of carcinogenesis. Also, regarding the disease-specific survival rate in laryngeal cancer, decreased expression of FHIT protein and increased expression of EGFR were useful as predictors of a poor prognosis.
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Report
(4 results)
Research Products
(12 results)