Two pore-domain potassium channel in retina : its functional expression and role of neuroprotection.
Project/Area Number |
21791674
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Ophthalmology
|
Research Institution | Kanazawa University |
Principal Investigator |
SAKURADA Norimasa Kanazawa University, 医学系, 協力研究員 (80377390)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | Kチャンネル / 網膜 / 神経保護 / ぶどう膜 |
Research Abstract |
The mRNA of two pore-domain potassium channel (K(2P)) was detected, and immunohistochemical findings showed TRAAK and TREK-2 expressions in the rat retina. However, patch-clamp study failed to detect K(2P) currents in isolated retinal cells. A KCNQ channel current was identified in porcine ciliary epithelial cells. Molecular biological analysis revealed that mRNAs of KCNQ1, 4 and 5 were expressed dominantly in ciliary body.
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Report
(3 results)
Research Products
(1 results)