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Two pore-domain potassium channel in retina : its functional expression and role of neuroprotection.

Research Project

Project/Area Number 21791674
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionKanazawa University

Principal Investigator

SAKURADA Norimasa  Kanazawa University, 医学系, 協力研究員 (80377390)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
KeywordsKチャンネル / 網膜 / 神経保護 / ぶどう膜
Research Abstract

The mRNA of two pore-domain potassium channel (K(2P)) was detected, and immunohistochemical findings showed TRAAK and TREK-2 expressions in the rat retina. However, patch-clamp study failed to detect K(2P) currents in isolated retinal cells. A KCNQ channel current was identified in porcine ciliary epithelial cells. Molecular biological analysis revealed that mRNAs of KCNQ1, 4 and 5 were expressed dominantly in ciliary body.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (1 results)

All Other

All Journal Article (1 results)

  • [Journal Article] Swelling-Activated Potassium Channel in Porcine Pigmented Ciliary Epithelial Cells.

    • Author(s)
      M Takahira, M Sakurai, N Sakurada, K Sugiyama.
    • Journal Title

      Investigative Ophthalmology & Visual Science (投稿中(査読後改変中))

    • NAID

      120003479729

    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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