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2010 Fiscal Year Final Research Report

Two pore-domain potassium channel in retina : its functional expression and role of neuroprotection.

Research Project

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Project/Area Number 21791674
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionKanazawa University

Principal Investigator

SAKURADA Norimasa  Kanazawa University, 医学系, 協力研究員 (80377390)

Project Period (FY) 2009 – 2010
KeywordsKチャンネル / 網膜 / 神経保護 / ぶどう膜
Research Abstract

The mRNA of two pore-domain potassium channel (K(2P)) was detected, and immunohistochemical findings showed TRAAK and TREK-2 expressions in the rat retina. However, patch-clamp study failed to detect K(2P) currents in isolated retinal cells. A KCNQ channel current was identified in porcine ciliary epithelial cells. Molecular biological analysis revealed that mRNAs of KCNQ1, 4 and 5 were expressed dominantly in ciliary body.

  • Research Products

    (1 results)

All Other

All Journal Article (1 results)

  • [Journal Article] Swelling-Activated Potassium Channel in Porcine Pigmented Ciliary Epithelial Cells.

    • Author(s)
      M Takahira, M Sakurai, N Sakurada, K Sugiyama.
    • Journal Title

      Investigative Ophthalmology & Visual Science (投稿中(査読後改変中))

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Published: 2012-02-13   Modified: 2016-04-21  

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