2010 Fiscal Year Final Research Report
Two pore-domain potassium channel in retina : its functional expression and role of neuroprotection.
| Project/Area Number |
21791674
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Kanazawa University |
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Principal Investigator |
SAKURADA Norimasa Kanazawa University, 医学系, 協力研究員 (80377390)
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| Project Period (FY) |
2009 – 2010
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| Keywords | Kチャンネル / 網膜 / 神経保護 / ぶどう膜 |
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| Research Abstract |
The mRNA of two pore-domain potassium channel (K(2P)) was detected, and immunohistochemical findings showed TRAAK and TREK-2 expressions in the rat retina. However, patch-clamp study failed to detect K(2P) currents in isolated retinal cells. A KCNQ channel current was identified in porcine ciliary epithelial cells. Molecular biological analysis revealed that mRNAs of KCNQ1, 4 and 5 were expressed dominantly in ciliary body.
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