2010 Fiscal Year Final Research Report
Two pore-domain potassium channel in retina : its functional expression and role of neuroprotection.
| Project/Area Number |
21791674
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
SAKURADA Norimasa Kanazawa University, 医学系, 協力研究員 (80377390)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | Kチャンネル / 網膜 / 神経保護 / ぶどう膜 |
|---|
| Research Abstract |
The mRNA of two pore-domain potassium channel (K(2P)) was detected, and immunohistochemical findings showed TRAAK and TREK-2 expressions in the rat retina. However, patch-clamp study failed to detect K(2P) currents in isolated retinal cells. A KCNQ channel current was identified in porcine ciliary epithelial cells. Molecular biological analysis revealed that mRNAs of KCNQ1, 4 and 5 were expressed dominantly in ciliary body.
|
Research Products
(1 results)
