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Pathology of retinitis pigmentosa detected by adaptive optics scanning laser ophthalmoscopy

Research Project

Project/Area Number 21791679
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionKyoto University

Principal Investigator

OOTO Sotaro  Kyoto University, 医学研究科, 助教 (10511850)

Co-Investigator(Renkei-kenkyūsha) HANGAI Masanori  京都大学, 大学院・医学研究科, 准教授 (70283687)
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords臨床研究 / 網膜色素変性 / 補償光学 / 走査型レーザー検眼鏡 / 眼底イメージング / 視細胞 / 網膜再生 / 光干渉断層計
Research Abstract

We investigated the pathology of retinitis pigmentosa by high-resolution photoreceptor images using adaptive optics scanning laser ophthalmoscopy. Abnormal patterns of cone mosaic were observed in retinitis pigmentosa though regular cone mosaic was seen in all normal eyes. Cone density was significantly decreased in retinitis pigmentosa, compared with normal eyes. Cone density correlated with visual function (visual acuity and retinal sensitivity). From these data we developed a program for evaluating visual prognosis, and showed that AO-SLO is useful for evaluating the treatment effect in patients with retinitis pigmentosa.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (38 results)

All 2011 2010 2009 Other

All Journal Article (18 results) (of which Peer Reviewed: 12 results) Presentation (20 results)

  • [Journal Article] High-resolution imaging of the photoreceptor layer in epiretinal membrane using adaptive optics scanning laser ophthalmoscopy.2011

    • Author(s)
      Ooto S, Hangai M, Takayama K, Sakamoto A, Tsujikawa A, jima Y, Inoue T, Yoshimura N.
    • Journal Title

      Ophthalmology 118

      Pages: 873-881

    • Related Report
      2010 Final Research Report
  • [Journal Article] Retinal microstructural abnormalities in central serous chorioretinopathy and polypoidal choroidal vasculopathy2011

    • Author(s)
      Sotaro Ooto, 他
    • Journal Title

      Retina

      Volume: 31 Pages: 527-534

    • NAID

      120004225529

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spectral-domain optical coherence tomography for three-dimensional visualization of the detached membrane in Valsalva retinopathy2011

    • Author(s)
      Tomoko Hasegawa, Sotaro Ooto, 他
    • Journal Title

      Japanese Journal of Ophthalmology

      Volume: 55 Pages: 81-83

    • NAID

      10029020714

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-resolution imaging of resolved central serous chorioretinopathy using adaptive optics scanning laser ophthalmoscopy.2010

    • Author(s)
      Ooto S, Hangai M, Sakamoto A, Tsujikawa A, Yamashiro K, Ojima Y, Yamada Y, Mukai H, Ojima Y, Inoue T, Yoshimura N.
    • Journal Title

      Ophthalmology 117

      Pages: 1800-1809

    • Related Report
      2010 Final Research Report
  • [Journal Article] AO-SLOによる黄斑上膜症例の視細胞構造2010

    • Author(s)
      大音壮太郎, 板谷正紀, 高山弘平, 坂本篤, 大島進, 井上卓, 吉村長久
    • Journal Title

      日本眼科学会雑誌第48回日本網膜硝子体学会総会学会トピックス 114

      Pages: 381-382

    • Related Report
      2010 Final Research Report
  • [Journal Article] 補償光学適用走査型レーザー検眼鏡による正常眼の網膜神経線維束構造2010

    • Author(s)
      高山弘平, 大音壮太郎, 板谷正紀, 羽根渕昌明, 大島進, 吉村長久
    • Journal Title

      日本眼科学会雑誌第46回日本眼光学学会総会学会トピックス 114

      Pages: 1043-1043

    • Related Report
      2010 Final Research Report
  • [Journal Article] High-Resolution Imaging of Resolved Central Serous Chorioretinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy2010

    • Author(s)
      Sotaro Ooto, 他
    • Journal Title

      Ophthalmology

      Volume: 117 Pages: 1800-1809

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thickness of photoreceptor layers in polypoidal choroidal vasculopathy and central serous chorioretinopathy2010

    • Author(s)
      Sotaro Ooto, 他
    • Journal Title

      Graefes Archive for Clinical and Experimental Ophthalmology

      Volume: 248 Pages: 1077-1086

    • NAID

      120002514711

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three-dimensional Profile of Macular Retinal Thickness in Normal Japanese Eyes2010

    • Author(s)
      Sotaro Ooto, 他
    • Journal Title

      Investigative Ophthalmology and Visual Sciences

      Volume: 51 Pages: 465-473

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macular hole formation following photodynamic therapy combined with intravitreal injection of bevacizumab and triamcinolone acetonide2010

    • Author(s)
      Daisuke Iwama, Sotaro Ooto, 他
    • Journal Title

      Japanese Journal of Ophthalmology

      Volume: 54 Pages: 364-366

    • NAID

      10027204735

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intravitreal bevacizumab for type 1 idiopathic macular telangiectasia2010

    • Author(s)
      Kohei Takayama, Sotaro Ooto, 他
    • Journal Title

      Eye (Lond)

      Volume: 24 Pages: 1492-1497

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three-dimensional Profile of Macular Retinal Thickness in Normal Japanese Eyes2010

    • Author(s)
      Sotaro Ooto, 他
    • Journal Title

      Investigative Ophthalmology and Visual Sciences 51

      Pages: 465-473

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photoreceptor Restoration in Unilateral Acute Idiopathic Maculopathy on Adaptive Optics Scanning Laser Ophthalmoscopy.

    • Author(s)
      Ooto S, Hangai M, Yoshimura N.
    • Journal Title

      Arch Ophthalmol (IN PRESS.)

    • Related Report
      2010 Final Research Report
  • [Journal Article] High-Resolution Photoreceptor Imaging in Idiopathic Macular Telangiectasia Type 2 Using Adaptive Optics Scanning Laser Ophthalmoscopy.

    • Author(s)
      Ooto S, Hangai M, Takayama K, Arakawa N, Tsujikawa A, Koizumi H, jima Y, Yoshimura N.
    • Journal Title

      Invest Ophthalmol Vis Sci (IN PRESS.)

    • Related Report
      2010 Final Research Report
  • [Journal Article] High-resolution imaging of photoreceptor layer in epiretinal membrane using adaptive optics scanning laser ophthalmoscopy

    • Author(s)
      Sotaro Ooto, 他
    • Journal Title

      Ophthalmology

      Volume: (IN PRESS)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photoreceptor Restoration in Unilateral Acute Idiopathic Maculopathy on Adaptive Optics Scanning Laser Ophthalmoscopy

    • Author(s)
      Sotaro Ooto, 他
    • Journal Title

      Archives of Ophthalmology

      Volume: (IN PRESS)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-Resolution lmaging of Resolved Central Serous Chorioretinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy

    • Author(s)
      Sotaro Ooto, 他
    • Journal Title

      Ophthalmology (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thickness of photoreceptor layers in polypoidal choroidal vasculopathy and central serous chorioretinopathy

    • Author(s)
      Sotaro Ooto, 他
    • Journal Title

      Graefes Archive for Clinical and Experimental Ophthalmology (印刷中)

    • NAID

      120002514711

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 網膜下液消失後の中心性漿液性脈絡網膜症のAO-SLOによる検討2011

    • Author(s)
      大音壮太郎, 荒川奈央子, 板谷正紀, 高山弘平, 田村寛, 山城健児, 大谷篤史, 辻川明孝, 大島進, 吉村長久
    • Organizer
      第115回日本眼科学会総会
    • Related Report
      2010 Final Research Report
  • [Presentation] シンポジウム「黄斑部毛細血管拡張症の病態と治療」AO-SLOによる視細胞構造異常所見2010

    • Author(s)
      大音壮太郎
    • Organizer
      日本網膜硝子体学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-11-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 専門別研究会(黄斑研究会)シンポジウム「最先端の画像診断」Adaptive Optics SLO2010

    • Author(s)
      大音壮太郎
    • Organizer
      日本臨床眼科学会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2010-11-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] High-resolution imaging of type2 idiopathic macular telangiectasia using adaptive optics scanning laser ophthalmoscopy2010

    • Author(s)
      Sotaro Ooto, 他
    • Organizer
      American Academy of Ophthalmology (AAO)
    • Place of Presentation
      Chicago (USA)
    • Year and Date
      2010-10-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] シンポジウム「眼底画像診断のこれから」AO-SLOによる視細胞イメージング2010

    • Author(s)
      大音壮太郎
    • Organizer
      日本眼循環学会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2010-07-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] High-resolution imaging of the photoreceptor layer in epiretinal membrane using adaptive optics scanning laser ophthalmoscopy.2010

    • Author(s)
      Ooto S, Hangai M, Takayama K, Sakamoto A, Tsujikawa A, Oshima S, Inoue T, Yoshimura N
    • Organizer
      ARVO/ISIE Imaging Conference
    • Place of Presentation
      Lauderdale, USA
    • Year and Date
      2010-05-01
    • Related Report
      2010 Final Research Report
  • [Presentation] High-resolution imaging of the photoreceptor layer in epiretinal membrane using adaptive optics scanning laser ophthalmoscopy2010

    • Author(s)
      Sotaro Ooto, 他
    • Organizer
      ARVO/ISIE Imaging Conference
    • Place of Presentation
      Fort Lauderdale (USA)
    • Year and Date
      2010-05-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] High-resolution imaging of type2 idiopathic macular telangiectasia using adaptive optics scanning laser ophthalmoscopy.2010

    • Author(s)
      Ooto S, Hangai M, Takayama K, Sakamoto A, Tsujikawa A, Oshima S, Inoue T, Yoshimura N
    • Organizer
      American Academy of Ophthalmology
    • Place of Presentation
      Chicago,USA
    • Related Report
      2010 Final Research Report
  • [Presentation] シンポジウム「眼底画像診断のこれから」AO-SLOによる視細胞イメージング2010

    • Author(s)
      大音壮太郎
    • Organizer
      第27回日本眼循環学会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] 専門別研究会(黄斑研究会)シンポジウム「最先端の画像診断」Adaptive Optics SLO.2010

    • Author(s)
      大音壮太郎
    • Organizer
      第64回日本臨床眼科学会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] シンポジウム「黄斑部毛細血管拡張症の病態と治療」AO-SLOによる視細胞構造異常所見2010

    • Author(s)
      大音壮太郎
    • Organizer
      第49回日本網膜硝子体学会総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] High-Resolution lmaging of the Photoreceptor Layer in Epiretinal Membrane Using Adaptive Optics Scanning Laser Ophthalmoscopy2009

    • Author(s)
      Sotaro Ooto, 他
    • Organizer
      American Academy of Ophthalmology
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 補償光学を適用した走査型レーザー検眼鏡による中心性漿液性網脈絡膜症の視細胞像2009

    • Author(s)
      大音壮太郎, 板谷正紀, 坂本篤, 尾島優美子, 田村寛, 山城健児, 大谷篤史, 辻川明孝, 吉村長久
    • Organizer
      第113回京都眼科学会
    • Place of Presentation
      泉都
    • Year and Date
      2009-09-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 補償光学を適用した走査型レーザー検眼鏡による中心性漿液性網脈絡膜症の視細胞像2009

    • Author(s)
      大音壮太郎, 他
    • Organizer
      第113回京都眼科学会
    • Place of Presentation
      京都
    • Year and Date
      2009-09-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] High-Resolution Imaging of the Photoreceptor Layer in the Epiretinal Membrane Using an Adaptive Optics Scanning Laser Ophthalmoscope.2009

    • Author(s)
      Ooto S, Hangai M, Tsujikawa A, Otani A, Oshima S, Inoue T, Yoshimura N
    • Organizer
      American Academy of Ophthalmology (AAO)
    • Place of Presentation
      San Francisco. USA.
    • Related Report
      2010 Final Research Report
  • [Presentation] 補償光学を適応した走査型レーザー検眼鏡を用いた中心性漿液性網脈絡膜症の視細胞構造2009

    • Author(s)
      大音壮太郎, 板谷正紀, 坂本篤, 山田善彦, 大島進, 井上卓, 吉村長久
    • Organizer
      第45回日本眼光学学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 補償光学適用走査型レーザー検眼鏡による中心性漿液性網脈絡膜症の視細胞構造2009

    • Author(s)
      大音壮太郎, 板谷正紀, 尾島優美子, 田村寛, 山城健児, 大谷篤史, 辻川明孝, 吉村長久
    • Organizer
      第63回日本臨床眼科学会総会
    • Place of Presentation
      博多
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 補償光学適用走査型レーザー検眼鏡による黄斑上膜症例の視細胞構造2009

    • Author(s)
      大音壮太郎, 板谷正紀, 高山弘平, 坂本篤, 大島進, 井上卓, 吉村長久
    • Organizer
      第48回日本網膜硝子体学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 補償光学付き走査型イメージング装置による生体眼底撮影

    • Author(s)
      山田善彦, 迎秀雄, 羽根渕昌明, 大島進, 大音壮太郎, 板谷正紀, 吉村長久
    • Related Report
      2010 Final Research Report
  • [Presentation] 教育セミナー「眼底画像診断の進歩」補償光学

    • Author(s)
      大音壮太郎
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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