| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
The pathogenesis of anorectal malformations(ARM) remains poorly understood and several factors should be involved in the morphogenesis of anorectal malformations, however, this study provides the evidence that PCSK5 and GDF11 expression in early hindgut morphogenesis could be the key factors in normal anorectal development which could be disturbed by administration of overdose of ATRA. To our knowledge, this is the first to investigate the interactions between ATRA and PCSK5/GDF11 in the hindgut region of ARM mice embryos. We believe that further analysis of the cascade reaction important for hindgut morphogenesis should help understanding of the pathogenesis of ARM in human.
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