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The molecular biological study for the maldevelopment of nerve and muscular system in model mice with anorectal malformations.

Research Project

Project/Area Number 21791734
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pediatric surgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

TSUDA Tomoki  京都府立医科大学, 医学研究科, 研修員 (40319132)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords直腸肛門奇形 / レチノイン酸 / 神経・筋発生 / モデルマウス / クラリーノ症候群
Research Abstract

The pathogenesis of anorectal malformations(ARM) remains poorly understood and several factors should be involved in the morphogenesis of anorectal malformations, however, this study provides the evidence that PCSK5 and GDF11 expression in early hindgut morphogenesis could be the key factors in normal anorectal development which could be disturbed by administration of overdose of ATRA. To our knowledge, this is the first to investigate the interactions between ATRA and PCSK5/GDF11 in the hindgut region of ARM mice embryos. We believe that further analysis of the cascade reaction important for hindgut morphogenesis should help understanding of the pathogenesis of ARM in human.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (27 results)

All 2011 2010 2009 Other

All Journal Article (11 results) (of which Peer Reviewed: 6 results) Presentation (15 results) Remarks (1 results)

  • [Journal Article] PCSK5 and GDF11 Expression in the Hindgut Region of Mouse Embryos With Anorectal Malformations2011

    • Author(s)
      Tsuda T, Iwai N, et al
    • Journal Title

      European Journal of Pediatric Surgery

      Volume: 21 Issue: 04 Pages: 238-241

    • DOI

      10.1055/s-0031-1273691

    • Related Report
      2011 Annual Research Report 2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of a rescue program for anorectal malformations induced by retinoic acid in mice2011

    • Author(s)
      Sasaki Y, Tsuda T, et al
    • Journal Title

      Journal of Pediatric Surgery

      Volume: 46 Issue: 7 Pages: 1396-1399

    • DOI

      10.1016/j.jpedsurg.2010.10.011

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hirschsprung病の標準的診断法について2011

    • Author(s)
      佐々木康成、津田知樹, 他
    • Journal Title

      小児外科

      Volume: 43巻 Pages: 623-626

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] 膵頭部原発ユーイング肉腫の3歳男児の1例(英語)2011

    • Author(s)
      小野滋、津田知樹, 他
    • Journal Title

      京都府立医科大学雑誌

      Volume: 120巻 Pages: 139-144

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 腹部打撲を契機に発見された膵頭部原発Ewing肉腫ファミリー腫瘍の1例2011

    • Author(s)
      若尾純子、津田知樹, 他
    • Journal Title

      小児がん

      Volume: 48巻 Pages: 7-11

    • NAID

      110008608573

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 直腸肛門内圧検査2010

    • Author(s)
      佐々木康成、津田知樹, 他
    • Journal Title

      小児外科

      Volume: 42巻 Pages: 756-759

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] 腹会陰式直腸肛門形成術々後成人例におけるQOL2010

    • Author(s)
      津田知樹、岩井直躬, 他
    • Journal Title

      小児外科

      Volume: 42巻 Pages: 1201-1204

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] Laparoscopic versus open abdominoperineal rectoplasy for infants with anorectalmalformation2010

    • Author(s)
      Kimura O, Tsuda T, et al
    • Journal Title

      Journal of Pediatric Surgery

      Volume: 45 Issue: 12 Pages: 2390-2393

    • DOI

      10.1016/j.jpedsurg.2010.08.042

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Laparoscopic versus open abdominoperineal rectoplasy for infants with anorectal malformation2010

    • Author(s)
      Kimura O, Tsuda T, et al
    • Journal Title

      Journal of Pediatric Surgery

      Volume: 45 Pages: 2390-2393

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 便秘なのにどうして便失禁となるの?2009

    • Author(s)
      岩井直躬、津田知樹
    • Journal Title

      小児外科

      Volume: 41巻 Pages: 1329-1332

    • Related Report
      2011 Final Research Report
  • [Journal Article] 便秘なのにどうして便失禁となるの?2009

    • Author(s)
      岩井直躬、津田知樹
    • Journal Title

      小児外科 41巻

      Pages: 1329-1332

    • Related Report
      2009 Annual Research Report
  • [Presentation] 小児外科領域における便秘に対する大建中湯の有効性2011

    • Author(s)
      津田知樹
    • Organizer
      第48回日本小児外科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-07-20
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 直腸肛門奇形の病態発生におけるPCSK5およびGDF11蛋白の発現に関する検討2011

    • Author(s)
      津田知樹
    • Organizer
      第111回日本外科学会定期学術集会
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 便失禁の診断と治療-特にバイオフィードバック療法について-2010

    • Author(s)
      津田知樹
    • Organizer
      第109回日本外科学会定期学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2010-11-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 客観的評価に基づいた小児排便障害に対する治療2010

    • Author(s)
      津田知樹
    • Organizer
      第65回 日本大腸肛門病学会学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2010-11-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] PCSK5 and GDF11 expression in the hindgut region of mouse embryos with anorectal malformations2010

    • Author(s)
      Tomoki Tsuda
    • Organizer
      57^<th> British Association of Paediatric Surgeons
    • Place of Presentation
      Aberdeen, Scotland
    • Year and Date
      2010-07-22
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 便失禁の診断と治療-特にバイオフィードバック療法について-2010

    • Author(s)
      津田知樹
    • Organizer
      第47回日本小児外科学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-06-19
    • Related Report
      2011 Final Research Report
  • [Presentation] 便失禁の診断と治療-特にバイオフノードバック療法について-2010

    • Author(s)
      津田知樹
    • Organizer
      第47回 日本小児外科学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-06-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] 当教室における小児の慢性便秘に対する治療について2010

    • Author(s)
      津田知樹
    • Organizer
      第40回日本小児消化管機能研究会
    • Place of Presentation
      甲府
    • Year and Date
      2010-02-20
    • Related Report
      2011 Final Research Report
  • [Presentation] 当教室における小児の慢性便秘に対する治療について2010

    • Author(s)
      津田知樹
    • Organizer
      第40回日本小児消化管機能研究会
    • Place of Presentation
      冨士桜荘(山梨県)
    • Year and Date
      2010-02-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 成人例のQOLからみた腹会陰式直腸肛門形成術の検討2009

    • Author(s)
      津田知樹
    • Organizer
      第25回日本小児外科学会秋季シンポジウム
    • Place of Presentation
      鹿児島
    • Year and Date
      2009-10-31
    • Related Report
      2011 Final Research Report
  • [Presentation] 成人例のQOLからみた腹会陰式直腸肛門形成術の検討2009

    • Author(s)
      津田知樹
    • Organizer
      第25回日本小児外科学会秋季シンポジウム
    • Place of Presentation
      鹿児島県市町村自治会館
    • Year and Date
      2009-10-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] 小児外科疾患における大建中湯の排便機能に及ぼす影響2009

    • Author(s)
      津田知樹
    • Organizer
      第185回近畿外科学会
    • Place of Presentation
      神戸
    • Year and Date
      2009-06-13
    • Related Report
      2011 Final Research Report
  • [Presentation] 思春期に繰り返すS状結腸捻転にて手術療法を施行した一例2009

    • Author(s)
      津田知樹
    • Organizer
      第185回近畿外科学会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2009-06-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] 小児外科疾患における大建中湯の排便機能に及ぼす影響2009

    • Author(s)
      津田知樹
    • Organizer
      第65回日本大腸肛門病学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2009-04-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 小児外科疾患における大建中湯の排便機能に及ぼす影響2009

    • Author(s)
      津田知樹
    • Organizer
      第109回日本外科学会定期学術集会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2009-04-03
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.kpu-m.ac.jp/k/pedsurg/index.php

    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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