Development of cultured cell-transplantation for hair regeneration therapy.

• Project/Area Number: 21791738
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Plastic surgery
• Research Institution: The University of Tokyo
• Principal Investigator: IIDA Takuya The University of Tokyo, 医学部附属病院, 助教 (00398603)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 毛髪再生 / 毛包再生 / 細胞移植 / ビタミンD / 毛乳頭細胞 / Sphere / sphere

Research Abstract

We established a clinically applicable transplantation method using expanded culture dermal papilla cells for hair regeneration therapy in animal model. This method is less invasive, simple and not required to use embryonic or neonatal keratinocyte. Thus, it is appropriate for clinical use. Furthermore, we developed culturing method to promote hair follicle induced potential of expanded dermal papilla cells by 1α, 25-dyhidroxyvitamin D_3-pretreatment.

Research Products

• [Journal Article] Clinically applicable transplantation procedure of dermal papilla cells for hair follicle regeneration (2011)
  • Author(s): Noriyuki Aoi
  • Journal Title: JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE Volume: (In printing)
  • Peer Reviewed
• [Journal Article] Clinically applicable transplantation procedure of dermal papilla cells for hair follicle regeneration. (2010)
  • Author(s): Aoi N, Inoue K, Kato H, Suga H, Higashino T, Eto H, Doi K, Araki J, Iida T, Katsuta T, Yoshimura K.
  • Journal Title: J Tissue Eng Regen Med In press.
  • Peer Reviewed
• [Presentation] 培養細胞移植による毛包再生:移植法および培養法の最適化にむけて (2010)
  • Author(s): 青井則之
  • Organizer: 第19回日本形成外科学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-16
• [Presentation] Optimization of cell construct grafting procedure for hair regeneration therapy (2010)
  • Author(s): 青井則之
  • Organizer: 6^<th> WORLD CONGRESS FOR HAIR RESEARCH
  • Place of Presentation: Cairns, Australia
  • Year and Date: 2010-06-17
• [Presentation] 1.25-dihydroxy vitamin D and All-Trans Retinoic Acid synergistically enhance Expression of wnt10b and alkaliphosphatase in human dermal cells via vitamin D receptor pathway (2010)
  • Author(s): 青井則之
  • Organizer: 6^<th> WORLD CONGRESS FOR HAIR RESEARCH
  • Place of Presentation: Cairns, Australia
  • Year and Date: 2010-06-17
• [Presentation] 毛髪再生のための毛乳頭細胞コンストラクトの移植法の検討 (2010)
  • Author(s): 青井則之
  • Organizer: 日本再生医療学会
  • Place of Presentation: 広島
  • Year and Date: 2010-03-19
• [Presentation] 毛髪のアンチエイジング:培養細胞を用いた毛髪再生の試み (2009)
  • Author(s): 青井則之
  • Organizer: 形成外科基礎学会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-01
• [Patent(Industrial Property Rights)] 毛髪再生用細胞移植方法 (2010)
  • Inventor(s): 吉村浩太郎, 井上啓太, 佐藤隆博
  • Industrial Property Rights Holder: 株式会社バイオマスター
  • Patent Publication Number: 2010-082339
  • Acquisition Date: 2010-04-15