| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Insulin-like growth factor-I(IGF-I) exerts beneficial effects on cognitive function. Because stimulation of sensory neurons induces IGF-I production by releasing calcitonin gene-related peptide(CGRP) in the mouse brain, we hypothesized that donepezil may have a stimulatory effect on sensory neurons in addition to an inhibitory effect on acetylcholinesterase, thereby promoting angiogesis and neurogenesis through an increase in IGF-I production in the hippocampus. To examine this possibility, we analyzed the effects of two selective acetylcholinesterase inhibitors(donepezil and tacrine) on hippocampal IGF-I production and cognitive function in WT mice, CGRP-knockout[CGRP(-/-)] mice, and WT mice with functional sensory denervation caused by neonatal administration of capsaicin.
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