Glutamatergic trigeminal circuits in relation to craniofacial bone metabolism
| Project/Area Number |
21791800
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
IMURA Kosuke The Nippon Dental University, 生命歯学部, 助教 (10415086)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 口腔解剖学(含組織学・発生学) / 頭頸部骨 / 末梢神経 / グルタミン酸 / 骨代謝 |
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| Research Abstract |
Some studies have discussed that the nervous system contributes to bone metabolism. However, the neuroanatomical basis for bone metabolism is not clear especially in craniofacial bones. I have investigated the innervations of craniofacial bones by means of immunohistochemistry. Distribution patterns of the peripheral nerve were detected using antibody against vesicular glutamate transporter (VGluT). The VGluT positive nerve (VGluT+) releases glutamate as neurotransmitter. I found the VGluT+ terminals in the periosteum. The osteoclast and osteoblast contribute to bone metabolism and express glutamate receptors. The VGluT+terminals may effect to the bone metabolism as an extrinsic neural source of glutamate. I have been continuing to identify parent neurons of the VGluT+.
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Report
(3 results)
Research Products
(5 results)
