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Glutamatergic trigeminal circuits in relation to craniofacial bone metabolism

Research Project

Project/Area Number 21791800
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Morphological basic dentistry
Research InstitutionThe Nippon Dental University

Principal Investigator

IMURA Kosuke  The Nippon Dental University, 生命歯学部, 助教 (10415086)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords口腔解剖学(含組織学・発生学) / 頭頸部骨 / 末梢神経 / グルタミン酸 / 骨代謝
Research Abstract

Some studies have discussed that the nervous system contributes to bone metabolism. However, the neuroanatomical basis for bone metabolism is not clear especially in craniofacial bones. I have investigated the innervations of craniofacial bones by means of immunohistochemistry. Distribution patterns of the peripheral nerve were detected using antibody against vesicular glutamate transporter (VGluT). The VGluT positive nerve (VGluT+) releases glutamate as neurotransmitter. I found the VGluT+ terminals in the periosteum. The osteoclast and osteoblast contribute to bone metabolism and express glutamate receptors. The VGluT+terminals may effect to the bone metabolism as an extrinsic neural source of glutamate. I have been continuing to identify parent neurons of the VGluT+.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (5 results)

All 2011 2010 Other

All Presentation (4 results) Remarks (1 results)

  • [Presentation] マウス頭頚部領域の骨における骨代謝関連神経支配について2011

    • Author(s)
      井村幸介、佐藤巌
    • Organizer
      第88回日本生理学会大会 第116回日本解剖学会総会・全国学術集会合同大会
    • Place of Presentation
      パシフィコ横浜(東日本震災の影響のため誌上発表となった)
    • Year and Date
      2011-03-30
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス頭頚部領域の骨における骨代謝関連神経支配について2011

    • Author(s)
      井村幸介
    • Organizer
      第88回日本生理学会大会 第116回日本解剖学会総会・全国学術集会合同大会
    • Place of Presentation
      パシフィコ横浜(東日本震災の影響の為、誌上発表)
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウス顎顔面領域の骨における神経分布について2010

    • Author(s)
      井村幸介、佐藤巌
    • Organizer
      第115回日本解剖学会総会・全国学術集会
    • Place of Presentation
      岩手県民会館(岩手県)
    • Year and Date
      2010-03-27
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 骨代謝機能に関連する顎顔面領域の骨組織における神経分布2010

    • Author(s)
      井村幸介、佐藤巌
    • Organizer
      第9回水生動物の行動と神経系シンポジウム
    • Place of Presentation
      名古屋大学(愛知県)
    • Year and Date
      2010-01-24
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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