Establishment of the novel criterion for anesthetic with characterisation of antioxidant property of intravenous anesthetics
Project/Area Number |
21792036
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Surgical dentistry
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Research Institution | Kanagawa Dental College |
Principal Investigator |
KOBAYASHI Kyo Kanagawa Dental College, 生体管理医学講座・薬理学分野, 特別研究員 (80513788)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 静脈麻酔薬 / 抗酸化作用 / 活性酸素種 / 電子スピン共鳴法 / ミダゾラム / 麻酔薬 / ESR / 酸化ストレス |
Research Abstract |
Previous reports have shown that reactive oxygen species (ROS) such as the hydroxyl radical (HO^・) and superoxide (O_2^<・->) can contribute to the various diseases. Midazolam is commonly used as intravenous anesthetics, the direct scavenging effects of midazolam on ROS have not been examined. HO^・ and O_2^<・-> were directly scavenged by midazolam at high concentrations (i.e., >4.6mM and>1.5mM, respectively) using electron spin resonance spectroscopy.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Direct Assessment of the Antioxidant Properties of Midazolam by Electron Spin Resonance Spectroscopy.2011
Author(s)
Hata M., Kobayashi K., Yoshino F., Yoshida A., Sugiyama S., Miyamoto C., Tokutomi F., Maehata Y., Wada- T S., Takahashi S.-S., Komatsu T., Yoshida K., Lee M-C.
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Journal Title
NAID
Related Report
Peer Reviewed
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