The responsiveness of dendritic cells against periodontitis-associated bacterial components at high glucose condition.

Research Project

Project/Area Number	21792135
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Periodontal dentistry
Research Institution	Aichi Gakuin University
Principal Investigator	FUJITA Sachiko Aichi Gakuin University, 歯学部, 非常勤講師 (70532993)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	歯周病 / 糖尿病 / 樹状細胞 / Periodontal Medicine / 免疫学
Research Abstract	High levels of CD80 and CD86 expressions, IL-12p35, IL-12/IL-23p40,IFN-gamma gene expressions and IL-12/IL-23p40 production were confirmed in dendritic cells isolated from mouse spleen cultured with high glucose. On one hand, there were no differences of IL-4 and IL-10 gene expressions between high glucose and low glucose condition. These results showed that high glucose condition stimulates dendritic cells and leads to increase the responsiveness against periodontits-associated bacteria.

Report

(3 results)