The responsiveness of dendritic cells against periodontitis-associated bacterial components at high glucose condition.
Project/Area Number |
21792135
|
Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Periodontal dentistry
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Research Institution | Aichi Gakuin University |
Principal Investigator |
FUJITA Sachiko Aichi Gakuin University, 歯学部, 非常勤講師 (70532993)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 歯周病 / 糖尿病 / 樹状細胞 / Periodontal Medicine / 免疫学 |
Research Abstract |
High levels of CD80 and CD86 expressions, IL-12p35, IL-12/IL-23p40,IFN-gamma gene expressions and IL-12/IL-23p40 production were confirmed in dendritic cells isolated from mouse spleen cultured with high glucose. On one hand, there were no differences of IL-4 and IL-10 gene expressions between high glucose and low glucose condition. These results showed that high glucose condition stimulates dendritic cells and leads to increase the responsiveness against periodontits-associated bacteria.
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Report
(3 results)
Research Products
(1 results)