The responsiveness of dendritic cells against periodontitis-associated bacterial components at high glucose condition.

• Project/Area Number: 21792135
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Periodontal dentistry
• Research Institution: Aichi Gakuin University
• Principal Investigator: FUJITA Sachiko Aichi Gakuin University, 歯学部, 非常勤講師 (70532993)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 歯周病 / 糖尿病 / 樹状細胞 / Periodontal Medicine / 免疫学

Research Abstract

High levels of CD80 and CD86 expressions, IL-12p35, IL-12/IL-23p40,IFN-gamma gene expressions and IL-12/IL-23p40 production were confirmed in dendritic cells isolated from mouse spleen cultured with high glucose. On one hand, there were no differences of IL-4 and IL-10 gene expressions between high glucose and low glucose condition. These results showed that high glucose condition stimulates dendritic cells and leads to increase the responsiveness against periodontits-associated bacteria.

Research Products

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