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first step for limb regeneration in higher vertebrates

Research Project

Project/Area Number 21870027
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Developmental biology
Research InstitutionOkayama University

Principal Investigator

SATOU Akira  Okayama University, 異分野融合先端研究コア, 助教 (90512004)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,756,000 (Direct Cost: ¥2,120,000、Indirect Cost: ¥636,000)
Fiscal Year 2010: ¥1,313,000 (Direct Cost: ¥1,010,000、Indirect Cost: ¥303,000)
Fiscal Year 2009: ¥1,443,000 (Direct Cost: ¥1,110,000、Indirect Cost: ¥333,000)
Keywords発生 / 再生 / ニワトリ / 四肢再生 / 四肢発生 / AER / AEC / Axolotl
Research Abstract

We were analyzing about limb regeneration in higher vertebrates. It was not described what happened after limb bud amputation in higher vertebrates. We first described events after limb bud amputation at histology and molecular level. Then we compared regenerative events in an amphibian and a chick. And we know AEC (apical epithelial cap) in an axolotl is the key of amphibian limb regeneration. Therefore, we next focused on AER (Apical epidermal ridge) since AER has been considered to be a functionally similar structure with the AEC. We found that AER was re-inducible after wounding by Wnt2b and Fgf-signaling. Our findings can be thought as a first step for mammalian limb regeneration.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (4 results)

All 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] The Apical ectodermal ridge (AER) can be re-induced by wounding, wnt-2b, and fgf-10 in the chicken limb bud2010

    • Author(s)
      佐藤伸、蒔苗亜紀、和田直之
    • Journal Title

      Developmental Biology 342(2)

      Pages: 157-168

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Apical ectodermal ridge (AER) can be re-induced by wounding, wnt-2b, and fgf-10 in the chicken limb bud2010

    • Author(s)
      Satoh A., Makanae A., Wada N.
    • Journal Title

      Developmental Biology

      Volume: 342(2) Pages: 157-166

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 高等脊椎動物(ニワトリ)における両生類型の再生システム覚醒への挑戦2009

    • Author(s)
      佐藤伸
    • Organizer
      発生学会秋季シンポジウム
    • Place of Presentation
      静岡・三島
    • Year and Date
      2009-11-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 高等脊椎動物(ニワトリ)における両生類型の再生システム覚醒への挑戦2009

    • Author(s)
      佐藤伸
    • Organizer
      日本発生生物学会 秋季シンポジウム
    • Place of Presentation
      静岡・三島
    • Year and Date
      2009-11-28
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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