Analysis of periostin isoform expressed uniquely in periodontal ligament tissue

Research Project

Project/Area Number	21890137
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Periodontal dentistry
Research Institution	Osaka University
Principal Investigator	MAEDA Kenichiro Osaka University, 歯学部附属病院, 医員 (90552068)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥2,561,000 (Direct Cost: ¥1,970,000、Indirect Cost: ¥591,000) Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000) Fiscal Year 2009: ¥1,326,000 (Direct Cost: ¥1,020,000、Indirect Cost: ¥306,000)
Keywords	歯根膜組織 / ペリオスチン
Research Abstract	We were enable to collect very high purity both periostin isofrom uniquely expressed in periodontal ligament (PDL-POSTIN) and full length periostin proteins (FULL-POSTIN) with adenovirus infection. Using these both purified proteins, we have found that affinity to Integrin αvβ3 of PDL-POSTIN is higher than that of FULL-POSTIN. These results suggest that PDL-POSTIN may have an important role in homeostatic mechanism and regeneration of periodontal tissue.

Report

(3 results)