| Project/Area Number |
21890296
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Public health/Health science
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
MORITA Makiko University of Occupational and Environmental Health, Japan, 医学部, 助教 (60530491)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
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| Keywords | 大腸がん / 大腸腺腫 / 酸化ストレス / 遺伝子多型 / 分子疫学 / 症例対照研究 / スーパーオキシドディスムターゼ / カタラーゼ / グルタチオンペルオキシターゼ |
|---|
| Research Abstract |
Oxidative stress causes DNA damage and may be involved in carcinogenesis. Endogenous antioxidant enzymes are known to be defensive against oxidative stress. To clarify the influence of the oxidative stress on colorectal carcinogenesis, we investigated the relation of functional genetic polymorphisms of manganese superoxide dismutase, catalase, and glutathione peroxidase to colorectal adenomas and cancer. None of the polymorphisms under study showed a measurable association with colorectal adenoma risk. A statistically significant decrease in the risk of colorectal cancer was observed among those with the T allele of CAT-262C>T.
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