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Genetic polymorphisms of antioxidant enzymes and colorectal carcinogenesis

Research Project

Project/Area Number 21890296
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Public health/Health science
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

MORITA Makiko  University of Occupational and Environmental Health, Japan, 医学部, 助教 (60530491)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
Keywords大腸がん / 大腸腺腫 / 酸化ストレス / 遺伝子多型 / 分子疫学 / 症例対照研究 / スーパーオキシドディスムターゼ / カタラーゼ / グルタチオンペルオキシターゼ
Research Abstract

Oxidative stress causes DNA damage and may be involved in carcinogenesis. Endogenous antioxidant enzymes are known to be defensive against oxidative stress. To clarify the influence of the oxidative stress on colorectal carcinogenesis, we investigated the relation of functional genetic polymorphisms of manganese superoxide dismutase, catalase, and glutathione peroxidase to colorectal adenomas and cancer. None of the polymorphisms under study showed a measurable association with colorectal adenoma risk. A statistically significant decrease in the risk of colorectal cancer was observed among those with the T allele of CAT-262C>T.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (15 results)

All 2011 2010 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (3 results) Remarks (3 results)

  • [Journal Article] Combined effects of coffee consumption and serum gamma-glutamyltransferase on serum C-reactive protein in middle-aged and elderly Japanese men and women2011

    • Author(s)
      Pham NM, Wang Z, Morita M, Ohnaka K, Adachi M, Kawate H, Takayanagi R, Kono S
    • Journal Title

      Clin Chem Lab Med (印刷中)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic polymorphisms of alcohol dehydrogenase and aldehyde dehydrogenase: Alcohol use and type 2 diabetes in Japanese men2011

    • Author(s)
      Yin G, Ohnaka K, Morita M, Tabata S, Tajima O, Kono S
    • Journal Title

      Epidemiol Res Int Volume 2011

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic polymorphisms of alcohol dehydrogenase and aldehyde dehydrogenase : Alcohol use and type 2 diabetes in Japanese men2011

    • Author(s)
      Yin G
    • Journal Title

      Epidemiology Research International

      Volume: 2011

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The relation of coffee consumption to serum uric acid in Japanese men and women aged 49-76 years2010

    • Author(s)
      Pham NM, Yoshida D, Morita M, Yin G, Toyomura K, Ohnaka K, Takayanagi R, Kono S
    • Journal Title

      J Nutr Met Volume 2010

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relation of cigarette smoking, alcohol use, and coffee consumption to glycated hemoglobin in Japanese men and women. Diab Met Syndr2010

    • Author(s)
      Maki T, Ikeda M, Morita M, Ohnaka K, Kawate H, Adachi M, Takayanagi R, Kono S
    • Journal Title

      Clin Res Rev 4(2)

      Pages: 69-73

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Takayanagi R. Inverse associations of serum bilirubin with high sensitivity C-reactive protein, glycated hemoglobin, and prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women2010

    • Author(s)
      Ohnaka K, Kono S, Inoguchi T, Yin G, Morita M, Adachi M, Kawate H
    • Journal Title

      Diabetes Res Clin Pract 88(1)

      Pages: 103-110

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The relation of coffee consumption to serum uric acid in Japanesemen and women aged 49-76 years2010

    • Author(s)
      Pham NM
    • Journal Title

      Journal of Nutrition and Metabolism

      Volume: 2010

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inverse associations of serum bilirubin with high sensitivity C-reactive protein, glycated hemoglobin, and prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women.2010

    • Author(s)
      Ohnaka K, et al.
    • Journal Title

      Diabetes Research and Clinical Practice 88

      Pages: 103-110

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relation of cigarette smoking, alcohol use, and coffee consumption to glycated hemoglobin in Japanese men and women.2010

    • Author(s)
      Maki T, et al.
    • Journal Title

      Diabetes & Metabolic Syndrome : Clinical Research & Reviews (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 抗酸化システム関連酵素の遺伝子多型と大腸腺腫 : 自衛官研究2010

    • Author(s)
      守田真基子
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 抗酸化システム関連酵素の遺伝子多型と大腸腺腫:自衛官研究2010

    • Author(s)
      守田真基子、銀光
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] XRCC1遺伝子多型と大腸がんリスク:福岡大腸がん研究2010

    • Author(s)
      銀光、守田真基子
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://www2.uoeh-u.ac.jp/research/index.php

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www2.uoeh-u.ac.jp/research/index.php

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.uoeh-u.ac.jp/research/rschls_j.phtml

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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