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Age-related difference of neural mechanisms underlying face memories in a social context

Research Project

Project/Area Number 21K03128
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 10040:Experimental psychology-related
Research InstitutionKyoto University

Principal Investigator

Tsukiura Takashi  京都大学, 人間・環境学研究科, 教授 (30344112)

Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords記憶 / 社会的文脈 / 加齢 / 脳 / fMRI / 顔
Outline of Research at the Start

表情や魅力など、ヒトの顔には多くの社会的情報が含まれており、それらの情報は他者との社会的関係の構築において重要な情報として利用されている。しかし、そのような社会的文脈における顔の認知処理は普遍的なものではなく、加齢や神経疾患などの脳の生物学的変化によって影響を受ける。本研究では、社会的文脈における顔の記憶とその脳内メカニズムが、加齢による脳の生物学的変化によってどのような影響を受けるのかについて、健常若年成人と健常高齢者を対象とした機能的時共鳴画像(fMRI)研究から解明する。

Outline of Final Research Achievements

In the present study, using functional magnetic resonance imaging (fMRI), we investigated the age-related difference in neural mechanisms underlying face memory in a social context.
The first fMRI study for young adults demonstrated that the prediction error related to facial attractiveness was represented by multivariate activity patterns in the ventral striatum, and that the modulatory effect of face memory by the prediction error in facial attractiveness was involved in interacting mechanisms between the ventral striatum and hippocampus. In addition, in the second fMRI study for both young and older adults, we found that the striatum representation related to the processing of face-based prediction errors in a social context was significant only in young adults, and that the ventral striatum-hippocampus interaction, which was active in all conditions of prediction errors in young adults, was preserved only in the positive prediction error condition in older adults.

Academic Significance and Societal Importance of the Research Achievements

顔に由来する社会的情報が顔の記憶にどのような影響を与えており、それがどのような脳内メカニズムを基盤としているのかについては、未だに多くの謎が残されている。本研究では、顔に関連する社会的文脈として顔の魅力の予測誤差に着目し、それらが顔の記憶に与える影響の基盤となる脳内メカニズムを、fMRIから検証した。この試みは、国内外にほとんど例のない新しいものであり、学術的意義も高いものであった。さらに、本研究ではこの脳内メカニズムに対する加齢の効果も検証されており、本研究の成果は高齢者の認知機能の維持・改善の基盤の理解へつながる社会的意義も高いものであった。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (5 results)

All 2024 2023 2022 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 3 results) Remarks (1 results)

  • [Journal Article] Remembering unexpected beauty: Contributions of the ventral striatum to the processing of reward prediction errors regarding the facial attractiveness in face memory2023

    • Author(s)
      Mihara Moe, Izumika Reina, Tsukiura Takashi
    • Journal Title

      NeuroImage

      Volume: 282 Pages: 120408-120408

    • DOI

      10.1016/j.neuroimage.2023.120408

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Neural mechanisms underlying the effect of prediction errors in facial attractiveness between masked and unmasked faces on face memories in young and older adults2024

    • Author(s)
      Mihara Moe, Kamo Akiho, Tsukiura Takashi
    • Organizer
      Society for Social Neuroscience 2024 Meeting, Tsukuba, Japan
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neural mechanisms underlying the effect of prediction errors in facial attractiveness between masked and unmasked faces on face memories in young and older adults2023

    • Author(s)
      Mihara Moe, Izumika Reina, Tsukiura Takashi
    • Organizer
      52th annual meeting of the Society for Neuroscience, Washington DC, USA
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Remembering unexpected beauty: Contributions of the ventral striatum to the effect of reward prediction errors in attractiveness for masked faces on face memories2022

    • Author(s)
      Mihara Moe、Izumika Reina、Tsukiura Takashi
    • Organizer
      29th Annual Meeting of the Cognitive Neuroscience Society (Online poster), San Francisco, USA
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Remarks] 研究室ホームページ

    • URL

      http://www.memory.jinkan.kyoto-u.ac.jp/index.html

    • Related Report
      2023 Annual Research Report 2022 Research-status Report 2021 Research-status Report

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Published: 2021-04-28   Modified: 2025-01-30  

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