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Clinical evaluation of chorioretinal melanin distribution in macular disease with multi-contrast optical coherence tomography.

Research Project

Project/Area Number 21K09684
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56060:Ophthalmology-related
Research InstitutionTokyo Medical University

Principal Investigator

Miura Masahiro  東京医科大学, 医学部, 教授 (60199958)

Co-Investigator(Kenkyū-buntansha) 安野 嘉晃  筑波大学, 医学医療系, 教授 (10344871)
巻田 修一  筑波大学, 医学医療系, 准教授 (50533345)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2023: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2022: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsメラニン / 網膜色素上皮 / 脈絡膜 / 光干渉断層計 / 偏光感受型光干渉断層計 / 黄斑疾患 / ぶどう膜炎 / 黄斑部疾患 / 偏光解析 / 偏光解消性 / Vokt-Koyanagi-Harada病 / 網膜色紙上皮
Outline of Research at the Start

網膜色素上皮メラニンと脈絡膜メラニンは視機能の維持に重要な役割を持っており、黄斑疾患の発症機序における重要なバイオマーカーと考えられている。しかし生体人眼における網脈絡膜メラニン定量計測手法は確立しておらず、眼科臨床では未だ主観的判断に基づいて診断しているのが現状である。本研究では、1回の無侵襲撮影によって、多角的情報(脈絡膜メラニン密度、網膜色素上皮メラニン分布、血流異常、通常のOCT画像)を同時取得可能である多機能光干渉断層計を用いることで、従来の手法では不可能であった網脈絡膜メラニン3次元定量解析を含む、黄斑疾患の包括的3次元多角的画像解析技術を確立する。

Outline of Final Research Achievements

We have successfully developed a 3D discrimination and quantification method for assessing retinal pigment epithelium (RPE) melanin and choroidal melanin using depolarization (DOPU) images obtained from polarization-sensitive optical coherence tomography (PS-OCT). By applying this method to normal eyes, we discovered that choroidal melanin density varies with age and location. Additionally, our quantitative analysis of choroidal melanin disorder in Vogt-Koyanagi-Harada (VKH) disease accurately discriminates the disorder caused by the disease and allows for tracking its progression. Furthermore, we applied 3D analysis to RPE melanin in age-related macular degeneration and genetic retinal diseases, successfully identifying RPE abnormalities. This research is significant because it sheds light on the distribution and characteristics of melanin in the retina and choroid, providing valuable insights for monitoring eye health and diagnosing specific conditions.

Academic Significance and Societal Importance of the Research Achievements

本研究で用いる多機能OCTによる網脈絡膜メラニン3次元定量解析技術の構築は、従来の手法では確認できなかった、黄斑疾患に関する新しい知見をもたらす可能性がある。まず脈絡膜メラニン密度解析はVokt-Koyanagi-Harada病の診断治療を大幅に向上させることが可能である。さらに網膜色素上皮メラニン3次元解析と自家蛍光画像を組み合わせることにより、黄斑疾患における網膜色素上皮異常の診断解析を革新的な変化をもたらすことが可能である。本技術を早期臨床応用することにより、我が国の医療技術および医療機器産業の発展が期待できる。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (45 results)

All 2024 2023 2022 2021 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 6 results) Presentation (37 results) (of which Int'l Joint Research: 16 results,  Invited: 2 results) Remarks (2 results)

  • [Journal Article] Synthesizing the degree of polarization uniformity from non-polarization-sensitive optical coherence tomography signals using a neural network2023

    • Author(s)
      Makita Shuichi、Miura Masahiro、Azuma Shinnosuke、Mino Toshihiro、Yasuno Yoshiaki
    • Journal Title

      Biomedical Optics Express

      Volume: 14 Issue: 4 Pages: 1522-1522

    • DOI

      10.1364/boe.482199

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Birefringence-derived artifact in optical coherence tomography imaging of the lamina cribrosa in eyes with glaucoma2023

    • Author(s)
      Miura Masahiro、Makita Shuichi、Yasuno Yoshiaki、Nakagawa Hayate、Azuma Shinnosuke、Mino Toshihiro、Miki Atsuya
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 17189-17189

    • DOI

      10.1038/s41598-023-43820-5

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Extending field-of-view of retinal imaging by optical coherence tomography using convolutional Lissajous and slow scan patterns2022

    • Author(s)
      Makita Shuichi、Azuma Shinnosuke、Mino Toshihiro、Yamaguchi Tatsuo、Miura Masahiro、Yasuno Yoshiaki
    • Journal Title

      Biomedical Optics Express

      Volume: 13 Issue: 10 Pages: 5212-5212

    • DOI

      10.1364/boe.467563

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Birefringence-derived scleral artifacts in optical coherence tomography images of eyes with pathologic myopia2022

    • Author(s)
      Miura Masahiro、Makita Shuichi、Yasuno Yoshiaki、Miki Atsuya、Nemoto Rei、Shimizu Hiroyuki、Azuma Shinnosuke、Mino Toshihiro、Yamaguchi Tatsuo
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 19713-19713

    • DOI

      10.1038/s41598-022-23874-7

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Objective evaluation of choroidal melanin loss in patients with Vogt-Koyanagi-Harada disease using polarization-sensitive optical coherence tomography2022

    • Author(s)
      Miura Masahiro、Makita Shuichi、Yasuno Yoshiaki、Azuma Shinnosuke、Mino Toshihiro、Yamaguchi Tatsuo、Iwasaki Takuya、Nemoto Rei、Shimizu Hiroyuki、Goto Hiroshi
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 3526-3526

    • DOI

      10.1038/s41598-022-07591-9

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of choroidal melanin-containing tissue in healthy Japanese subjects by polarization-sensitive optical coherence tomography2022

    • Author(s)
      Miura Masahiro、Makita Shuichi、Yasuno Yoshiaki、Iwasaki Takuya、Azuma Shinnosuke、Mino Toshihiro、Yamaguchi Tatsuo
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 4048-4048

    • DOI

      10.1038/s41598-022-07818-9

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Generative multi-contrast OCT for the analysis of retinal tissue property2024

    • Author(s)
      T Seesan, S Makita, M Miura, Y Yasuno
    • Organizer
      BiOS Photonic West
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 病的近視眼の光干渉断層計画像における強膜血管類似artifact2023

    • Author(s)
      三浦雅博、三木篤也、根本怜、清水広之、東神之介、三野聡大、巻田修一、安野嘉晃
    • Organizer
      第126回日本眼科学会総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Birefringence derived artifact in OCT imaging of eyes with pathologic myopia and glaucoma2023

    • Author(s)
      M Miura, S Makita, Y Yasuno, R Nemoto, H Shimizu, S Azuma, T Mino, A Miki
    • Organizer
      ARVO
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] High-density and >20-degree field-of-view Lissajous scan optical coherence tomography angiographyin diabetic retinopathy2023

    • Author(s)
      Y Yasuno, M Miura, S Azuma, T Mino, S Makita
    • Organizer
      ARVO
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 篩状板OCT画像のartifact2023

    • Author(s)
      三浦雅博
    • Organizer
      第34回日本緑内障学会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Deep learning-based multi-contrast optical coherence tomography for retinal tissue analysis2023

    • Author(s)
      T Seesan, S Makita, M Miura, Y Yasuno
    • Organizer
      Optics & Photonics Japan
    • Related Report
      2023 Annual Research Report
  • [Presentation] 常染色体劣性ベストロフィノパチーに対する多角的画像解析2023

    • Author(s)
      三浦雅博、巻田修一、安野嘉晃、東神之介、三野聡大、亀谷修平、角田和繁
    • Organizer
      第62回日本網膜硝子体学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Multimodal imaging analysis for the eyes with autosomal recessive bestrophinopathy2023

    • Author(s)
      M Miura, S Makita, Y Yasuno, S Azuma, S Kameya, K Tsunoda
    • Organizer
      APVRS
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesizing retinal degree of polarization uniformity from OCT with OCT-angiography by deep learning2023

    • Author(s)
      Yusong Liu, Shuichi Makita, Masahiro Miura, Takuya Iwasaki, Toshihiro Mino, Tatsuo Yamaguchi, Shinnosuke Azuma, Yoshiaki Yasuno
    • Organizer
      Photonic West BiOS
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Extended field-of-view, high-dense spatial sampling microvasculature imaging using Lissajous OCT angiography2023

    • Author(s)
      Shuichi Makita, Masahiro Miura, Shinnosuke Azuma, Toshihiro Mino, Tatsuo Yamaguchi, Yoshiaki Yasuno
    • Organizer
      Photonic West BiOS
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] 病的近視の強膜光干渉断層計画像における複屈折由来artifact2023

    • Author(s)
      三浦雅博、巻田修一、安野嘉晃、三木篤也、根本怜、清水広之、東神之介、三野聡大、山口達夫
    • Organizer
      第54回筑波大学眼科集談会
    • Related Report
      2022 Research-status Report
  • [Presentation] 偏光感受型OCTによるVogt―小柳―原田病における脈絡膜メラニン障害の部位別解析2022

    • Author(s)
      三浦雅博、巻田修一、安野嘉晃、根本怜、清水広之、岩崎琢也、後藤浩、東神之介、三野聡大、山口達夫
    • Organizer
      第126回日本眼科学会総会
    • Related Report
      2022 Research-status Report
  • [Presentation] Evaluation of RPE changes in serous pigment epithelial detachment in AMD2022

    • Author(s)
      Masahiro Miura, Shuichi Makita, Yoshiaki Yasuno, Takuya Iwasaki, Shinnosuke Azuma, Toshihiro Mino, Tatsuo Yamaguchi
    • Organizer
      FUJI RETINA
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Volumetric evaluation of choroidal depigmentation in the eyes with Vogt-Koyanagi-Harada disease using polarization-sensitive OCT2022

    • Author(s)
      Masahiro Miura, Shuichi Makita, Yoshiaki Yasuno, Shinnosuke Azuma, Toshihiro Mino, Tatsuo Yamaguchi, Takuya Iwasaki, Rei Nemoto, Hiroyuki Shimizu, Hiroshi Goto
    • Organizer
      The Association for Research in Vision and Ophthalmology
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] High-density and >20-degree field-of-view en-face and three-dimensional posterior eye imaging by Lissajous scan optical coherence tomography and angiography2022

    • Author(s)
      Shuichi Makita, Masahiro Miura, Shinnosuke Azuma, Toshihiro Mino, Tatsuo Yamaguchi, Yoshiaki Yasuno
    • Organizer
      The Association for Research in Vision and Ophthalmology
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Synthesizing degree-of-polarization-uniformity from non-polarization sensitive OCT by convolutional neural network2022

    • Author(s)
      Yoshiaki Yasuno, Kensuke Oikawa, Masahiro Miura, Takuya Iwasaki, Toshihiro Mino, Tatsuo Yamaguchi, Shuichi Makita
    • Organizer
      The Association for Research in Vision and Ophthalmology
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] 偏光OCTによる網脈絡膜疾患におけるメラニン分布解析2022

    • Author(s)
      三浦雅博
    • Organizer
      Tokyo Retina League
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 漿液性網膜色素上皮剥離の自壊例における網膜色素上皮異常の経時的変化2022

    • Author(s)
      佐々木翔太郎、禰津直弘、巻田修一、安野嘉晃、東神之介、山口達夫、三野聡大、三浦雅博
    • Organizer
      第76回日本臨床眼科学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 加齢黄斑変性に併発した漿液性網膜色素上皮剥離の自発蛍光画像の評価2022

    • Author(s)
      禰津直弘、佐々木翔太郎、三浦雅博
    • Organizer
      第76回日本臨床眼科学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 漿液性網膜色素上皮剥離の自壊例における網膜色素上皮異常の経時的変化2022

    • Author(s)
      佐々木翔太郎、禰津直弘、三浦雅博、巻田修一、安野嘉晃、東神之介、山口達夫、三野聡大、岩崎琢也
    • Organizer
      令和4年度茨城県眼科医会集談会
    • Related Report
      2022 Research-status Report
  • [Presentation] 加齢黄斑変性に併発した漿液性網膜色素上皮剥離の自発蛍光画像の評価2022

    • Author(s)
      三浦雅博、禰津直弘、佐々木翔太郎、岩崎琢也
    • Organizer
      令和4年度茨城県眼科医会集談会
    • Related Report
      2022 Research-status Report
  • [Presentation] 病的近視の強膜光干渉断層計画像における複屈折由来artifact2022

    • Author(s)
      三浦雅博、巻田修一、安野嘉晃、三木篤也、根本怜、清水広之、東神之介、三野聡大、山口達夫
    • Organizer
      第61回日本網膜硝子体学会
    • Related Report
      2022 Research-status Report
  • [Presentation] Synthesizing degree of polarization uniformity from non-polarization sensitive OCT by convolutional neural network2022

    • Author(s)
      Oikawa K, Makita S, Miura M, Iwasaki T, Mino T, Yamaguchi T, Yasuno Y
    • Organizer
      Photonic West BiOS
    • Related Report
      2021 Research-status Report
  • [Presentation] Investigation of three-dimensional motion-free imaging of retinal diseases by Lissajous optical coherence tomography2022

    • Author(s)
      Makita S, Miura M,Azuma S, Mino T, Yamaguchi T, Yasuno Y
    • Organizer
      Photonic West BiOS
    • Related Report
      2021 Research-status Report
  • [Presentation] Motion-free imaging of vasculature and pigment by Lissajous polarization OCT2021

    • Author(s)
      Yasuno Y, Makita S, Miura M
    • Organizer
      The 2nd International Ocular Circulation Society
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Choroidal melanin thickness measurement in healthy Japanese subjects by polarization-sensitive optical coherence tomography2021

    • Author(s)
      Miura M, Makita S, Yasuno Y, Iwasaki T, Azuma S, Mino T, Yamaguchi T
    • Organizer
      The 2nd International Ocular Circulation Society
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 偏光感受型OCTによるVogt―小柳―原田病における脈絡膜メラニン異常の経時分析2021

    • Author(s)
      三浦雅博、巻田修一、安野嘉晃、東神之介、山口達夫、三野聡大、岩崎琢也、後藤浩
    • Organizer
      第125回日本眼科学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] Accurately motion-corrected OCT by Lissajous scan and OCT-and-OCTA based motion correction2021

    • Author(s)
      Makita S, Miura M, Mino T, Azuma S, Yamaguchi T, Yasuno Y
    • Organizer
      The Association for Research in Vision and Ophthalmology
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Choroidal melanin thickness measurement in healthy Japanese subjects by polarization-sensitive optical coherence tomography2021

    • Author(s)
      Miura M, Makita S, Yasuno Y, Iwasaki T, Azuma S, Mino T, Yamaguchi T
    • Organizer
      The Association for Research in Vision and Ophthalmology
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Imaging quality of Lissajous scan OCT for in vivo retinal imaging2021

    • Author(s)
      Yasuno Y, Miura M, Mino T, Azuma S, Yamaguchi T, Makita S
    • Organizer
      The Association for Research in Vision and Ophthalmology
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Synthesizing degree-of-polarization-uniformity from non-polarization sensitive OCT by convolutionalneural network2021

    • Author(s)
      Oikawa K, Makita S, Miura M, Iwasaki T, Mino T, Yamaguchi T, Yasuno Y
    • Organizer
      ARVO imaging conference
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 偏光感受型OCTによる正常眼における脈絡膜実質メラニン厚の検討2021

    • Author(s)
      三浦雅博、巻田修一、安野嘉晃、東神之介、山口達夫、三野聡大、岩崎琢也
    • Organizer
      第75回日本臨床眼科学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 偏光感受型OCTによるVogt―小柳―原田病における脈絡膜メラニン障害の定量解析2021

    • Author(s)
      三浦雅博、巻田修一、安野嘉晃、根本怜、清水広之、岩崎琢也、後藤浩、東神之介、三野聡大、山口達夫
    • Organizer
      第60回日本網膜硝子体学会
    • Related Report
      2021 Research-status Report
  • [Presentation] OCT による眼底三次元構造イメージング2021

    • Author(s)
      巻田修一、三浦雅博、東神之介、三野聡大、山口達夫、安野嘉晃
    • Organizer
      第60回日本網膜硝子体学会
    • Related Report
      2021 Research-status Report
  • [Presentation] CNNを用いた OCT画像からの偏光均一性画像の生成2021

    • Author(s)
      及川健介、巻田修一 、三浦雅博 、岩崎琢也 、三野聡大、山口達夫、安野嘉晃
    • Organizer
      第60回日本網膜硝子体学会
    • Related Report
      2021 Research-status Report
  • [Presentation] In vivo three-dimensional motion-free retinal imaging by Lissajous optical coherence tomography2021

    • Author(s)
      Makita S, Azuma S, Mino T, Yamaguchi T, Miura M, Yasuno Y
    • Organizer
      Optics & Photonics Japan 2021
    • Related Report
      2021 Research-status Report
  • [Presentation] Synthesizing degree of polarization uniformity from non-polarization-sensitive optical coherence tomography signals by convolutional neural network2021

    • Author(s)
      Oikawa K, Makita S, Miura M, Iwasaki T, Mino T, Yamaguchi T, Yasuno Y
    • Organizer
      Optics & Photonics Japan 2021
    • Related Report
      2021 Research-status Report
  • [Remarks] Dr. Masahiro Miura's Page

    • URL

      http://www.tokyo-med.ac.jp/iba-eye/miura_title.html

    • Related Report
      2022 Research-status Report
  • [Remarks]

    • URL

      http://www.tokyo-med.ac.jp/iba-eye/miura_title.html

    • Related Report
      2021 Research-status Report

URL: 

Published: 2021-04-28   Modified: 2025-01-30  

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