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Development of a new optimization system to mitigate plan complexity for VMAT

Research Project

Project/Area Number 21K15782
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionKyoto University

Principal Investigator

Ono Tomohiro  京都大学, 医学研究科, 特定助教 (90782657)

Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2023: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsVMAT / QA / 最適化 / 機械学習 / QA結果予測
Outline of Research at the Start

本研究の目的は、複雑な照射技法を伴う強度変調回転放射線治療(Volumetric-Modulated Arc Therapy: VMAT)における計画線量と実測線量との乖離に与える原因を特定すると共に、その克服により照射形状を最適化し、新たなVMAT最適化システムを構築することである。本システムの構築はVMATプランの複雑さを軽減し、効率的な最適化手法として確立され、計画された線量が実線量として患者へ安全かつ適切に照射される放射線治療の提供が可能となることが期待される。

Outline of Final Research Achievements

A new VMAT optimization system was developed by identifying the causes of the discrepancy between the planned dose and the measured dose in volumetric-modulated arc therapy (VMAT) with complex irradiation techniques and optimizing to improve plan quality as following; (1) identifying the irradiation parameters that affect the plan complexity of the VMAT plan and analyzing the complexity index, (2) modifying the irradiation shape of the VMAT plan to the optimal position, and (3) quantitatively evaluating the usefulness of the plan before and after modification to develop an optimization system to reduce plan complexity. system, and these results were accepted by an international academic journal.

Academic Significance and Societal Importance of the Research Achievements

VMATプランの複雑さを軽減する手法として、米国Varian社の治療計画装置より(Aperture Shape Controller: ASC)という機能が搭載された。ASCは照射野を形成するMLCの位置変化を抑え、プランの複雑さを軽減するという機能である。しかしASC機能が必ずしも計算値と実測値の乖離を軽減するとは限らない。本研究における最適化手法はQA予測システムに基づき、計算値と実測値の乖離を少なくかつ複雑さを軽減するものであり、国内外の何れにおいても未だ報告はない。将来的にはQA結果を見越しプランを修正する効率的な最適化手法として、高精度放射線治療の発展と普及に大いに貢献すると考える。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (15 results)

All 2024 2023 2022 2021

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (8 results) (of which Int'l Joint Research: 5 results,  Invited: 1 results)

  • [Journal Article] Influence of dose calculation algorithms on the helical diode array using volumetric‐modulated arc therapy for small targets2024

    • Author(s)
      Ono Tomohiro、Hirashima Hideaki、Adachi Takanori、Iramina Hiraku、Fujimoto Takahiro、Uto Megumi、Nakamura Mitsuhiro、Mizowaki Takashi
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: NA Issue: 7 Pages: 1-9

    • DOI

      10.1002/acm2.14307

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development and multi-institutional evaluation of a new phantom for verifying beam-positioning errors at off-isocenter positions2023

    • Author(s)
      Kido Takahisa、Ono Tomohiro、Nakamura Mitsuhiro、Ishihara Yoshitomo、Itoh Hiroyuki、Matsugi Kiyotomo、Yoshimoto Atsushi、Kishigami Yukako、Mizowaki Takashi
    • Journal Title

      Physica Medica

      Volume: 112 Pages: 102645-102645

    • DOI

      10.1016/j.ejmp.2023.102645

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effect of angular dependence for small‐field dosimetry using seven different detectors2023

    • Author(s)
      Kawata Kohei、Ono Tomohiro、Hirashima Hideaki、Tsuruta Yusuke、Fujimoto Takahiro、Nakamura Mitsuhiro、Nakata Manabu
    • Journal Title

      Medical Physics

      Volume: 50 Issue: 3 Pages: 1274-1289

    • DOI

      10.1002/mp.16198

    • Related Report
      2022 Research-status Report
  • [Journal Article] Automatic measurement of beam‐positioning accuracy at off‐isocenter positions2022

    • Author(s)
      Ono Tomohiro、Kido Takahisa、Nakamura Mitsuhiro、Iramina Hiraku、Kakino Ryo、Mizowaki Takashi
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 24 Issue: 3

    • DOI

      10.1002/acm2.13844

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Small-field dosimetry with detector-specific output correction factor for single-isocenter stereotactic radiotherapy of single and multiple brain metastases2022

    • Author(s)
      Ono Tomohiro、Kawata Kohei、Nakamura Mitsuhiro、Uto Megumi、Mizowaki Takashi
    • Journal Title

      Radiological Physics and Technology

      Volume: 16 Issue: 1 Pages: 10-19

    • DOI

      10.1007/s12194-022-00684-0

    • Related Report
      2022 Research-status Report
  • [Journal Article] Evaluation of internal margins for prostate for step and shoot intensity‐modulated radiation therapy and volumetric modulated arc therapy using different margin formulas2022

    • Author(s)
      Higuchi Daiki、Ono Tomohiro、Kakino Ryo、Aizawa Rihito、Nakayasu Naoki、Ito Hitoshi、Sakamoto Takashi
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 23 Issue: 9

    • DOI

      10.1002/acm2.13707

    • Related Report
      2022 Research-status Report
  • [Journal Article] Development of a plan complexity mitigation algorithm based on gamma passing rate predictions for volumetric‐modulated arc therapy2022

    • Author(s)
      Ono Tomohiro、Nakamura Mitsuhiro、Ono Yuka、Nakamura Kiyonao、Mizowaki Takashi
    • Journal Title

      Medical Physics

      Volume: 49 Issue: 3 Pages: 1793-1802

    • DOI

      10.1002/mp.15466

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Presentation] Unification of GPR criteria using Bland-Altman analysis considering the systematic errors of measurement-, calculation-, and prediction-based PSQA methods of VMAT for lung cancer2023

    • Author(s)
      T. Ono, T. Adachi, H. Hirashima, H. Iramina, N. Kishi, Y. Matsuo, M. Nakamura and T. Mizowaki
    • Organizer
      AAPM 2023, 65th Annual Meeting & Exhibition
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dosimetric impact of heterogeneity correction algorithm in intracavitary high-dose-rate brachytherapy for cervical cancer with applicator models2023

    • Author(s)
      Y Kishigami, T Ono, N Matsushita, H Hirashima, H Iramina, T Adachi, A Nakajima , T Mizowaki, M Nakamura
    • Organizer
      AAPM 2023, 65th Annual Meeting & Exhibition
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ライブラリ機能を用いたアプリケータモデリングの効率化2023

    • Author(s)
      小野智博
    • Organizer
      小線源治療部会第25回学術大会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 婦人科腫瘍に対する画像誘導密封小線源治療におけるinverse planningの有用性2023

    • Author(s)
      小野智博、岸上祐加子、松下矩正、平島英明、伊良皆拓、足立孝則、中嶋綾、中村光宏、溝脇尚志
    • Organizer
      日本放射線腫瘍学会第36回学術大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] VMAT-STIに対する円筒型検出器を用いた患者QAにおける線量計算アルゴリズムの特性評価2023

    • Author(s)
      小野智博、平島英明、足立孝則、伊良皆拓、藤本隆広、宇藤恵、中村光宏、溝脇尚志
    • Organizer
      第56回京都放射線腫瘍研究会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Development of Plan Complexity Mitigation Algorithm for VMAT2021

    • Author(s)
      Tomohiro Ono, Mitsuhiro Nakamura, Takashi Mizowaki
    • Organizer
      AAPM 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Small-Field Dosimetry in Single-Isocenter Stereotactic Irradiation for Brain Metastases Using a Detector-Specific Field Output Correction Factor2021

    • Author(s)
      Tomohiro Ono, Mitsuhiro Nakamura, Megumi Uto, Takashi Mizowaki
    • Organizer
      AAPM 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Unification of QA criteria considering the systematic errors of measurement-, calculation-, and prediction-based QA methods for VMAT2021

    • Author(s)
      Tomohiro Ono, Mitsuhiro Nakamura, Yukinori Matsuo, Takashi Mizowaki
    • Organizer
      21th AOCMP
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research

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Published: 2021-04-28   Modified: 2025-01-30  

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