| Project/Area Number |
21K16152
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53030:Respiratory medicine-related
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| Research Institution | Kurume University |
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Principal Investigator |
Sasaki Jun 久留米大学, 医学部, 助教 (60569424)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2023: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 小児喘息 / 肺の発育障害 / 低肺機能 / 喘息コントロール / 気管支喘息 / 小児 / 気管支ぜん息 / 生命予後 / コホート |
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| Outline of Research at the Start |
申請者は、乳幼児から小児期のぜん息は肺の発育障害の要因で、成人期の非喫煙の慢性閉塞性肺疾患に進展するという作業仮説を建てた。本研究では、大牟田市のコホート研究データを用いて、小児ぜん息のコントロールレベルに応じた肺機能データの経年変化および成人に達した際の気流閉塞保有率を比較検討する。また気流閉塞の有無が生命予後にどのように関与するかを検証することで、ぜん息に対する新たな管理法の開発に繋げたい。
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| Outline of Final Research Achievements |
We included 505 children with asthma from the Omuta City Air Pollution-Related Health Damage Cohort Program. The characteristics and lung function of girls and boys aged 6-11 years and 12-17 years were compared between poor and good asthma control groups. The mean percentage forced expiratory volume in 1 second predicted for girls and boys aged 6-11 years and 12-17 years in the poor control group was significantly lower than those of girls and boys aged 6-11 years and 12-17 years in the good control group. However, a linear regression model did not reveal between-group differences in the slopes of lung function growth for both sexes. Girls and boys in the poor control group had a significantly higher proportion of young adults with obstructive ventilatory patterns than girls and boys in the good control group. Our findings revealed that poor childhood asthma control leaded to lung function disorders, which suggest the importance of early asthma control in school children.
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| Academic Significance and Societal Importance of the Research Achievements |
海外での報告と同様に、小児期の喘息コントロール不良が小児期および若年成人期の低肺機能につながることが、日本人の長期コホートデータにおいても確認できた。小児期の早期かつ持続的な喘息管理は、成人期に正常な肺機能を維持すること、さらには肺の成長障害に伴う慢性閉塞性肺疾患の発症割合を減少させることにつながると考えられる。小児期からの早期かつ持続的な喘息管理の重要性が示された。
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