Development of prevention strategies of musculoskeletal diseases in men at different life stages using population-based cohort study
Project/Area Number |
21K19631
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Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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Allocation Type | Multi-year Fund |
Review Section |
Medium-sized Section 58:Society medicine, nursing, and related fields
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Research Institution | The University of Tokyo |
Principal Investigator |
吉村 典子 東京大学, 医学部附属病院, 特任教授 (60240355)
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Co-Investigator(Kenkyū-buntansha) |
岡 敬之 東京大学, 医学部附属病院, 特任准教授 (60401064)
飯高 世子 東京大学, 医学部附属病院, 特任助教 (80800680)
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Project Period (FY) |
2021-07-09 – 2024-03-31
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Project Status |
Completed (Fiscal Year 2023)
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Budget Amount *help |
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2023: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | 男性骨粗鬆症 / 運動器疾患 / ライフステージ / 地域住民コホート / 要介護予防 / 性ホルモン / 長期トレンド / 男性のライフステージ / 検診プログラム |
Outline of Research at the Start |
要介護の上位疾患である運動器疾患(サルコペニア:SP、骨粗鬆症:OP、変形性関節症:OA)には性差があるが、男性に焦点を当てた研究は少なく、実態は未解明である。申請者らは、2005年地域住民コホート(ROADスタディ)を構築し、過去5回13年にわたる調査を実施した。本研究では蓄積した検診結果をデータリンケージし、男性運動器疾患の発生率、危険因子を解明し、予後への影響を明らかにする。得られたエビデンスを元に、ライフステージ(中壮年期、熟年期、老年期)からみた男性の運動器疾患予防検診プログラムを開発し、17年目のROADスタディ第6回調査に応用し、効率的なスクリーニング方法を確立する。
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Outline of Annual Research Achievements |
我々は2005年に設定した住民コホートROAD(Research on Osteoarthritis/osteoporosis Against Disability, 男性参加者1,061人, 平均71歳)に長期蓄積した情報を用いて、男性における運動器疾患の中からまずOPを研究対象疾患とし、それらの疫学指標、予後及び危険因子を解明することを目的とした。 まず男性OPの長期トレンドを検討した。ベースライン調査および10年目の第4回調査結果の同年代のOPの有病率を比較したところ、男性のOPは腰椎において近年有意に低下していることがわかった(J Bone Min Metab40: 829, 2022)。 次に第3回ROAD study参加男性513人を6年間追跡しその予後を確認した。6年間で要介護発生が確認できたのは22人であった。6年後の要介護の有無を目的変数とし、ベースライン時のOPの有無を説明変数とし、年齢、体格、地域を調整して、ロジスティック回帰分析を行ったところ、OPありの要介護発生に対するオッズ比は14.7 (95%信頼区間2.2-97.3, p=0.005)となり、男性OPはその後の要介護の発生に有意に影響を及ぼしていることがわかった。一方死亡との関連は有意ではなかった(オッズ比2.7, 0.61-12.2, 0.186)。次に男性OPに関連する要因として性ホルモンに着目し、血清estradiol,dehydroepiandrosterone sulfate,free testosterone値とOPとの関連を解析したがいずれも有意ではなかった。 今回の結果から、長期的にみると男性OPの有病率は低下傾向にあるが、男性OPになると要介護のリスクが遥かに高いことがわかり、男性運動器疾患予防の重要性が示唆された。今後他の運動器疾患についても同様の解析を実施する。
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Report
(3 results)
Research Products
(137 results)
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[Journal Article] Prevalence and distribution of Schmorl node and endplate signal change, and correlation with disc degeneration in a population-based cohort: the Wakayama Spine Study2024
Author(s)
Teraguchi M, Hashizume H, Oka H, Kagotani R, Nagata K, Ishimoto Y, Tanaka S, Yoshida M, Yoshimura N, Yamada H
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Journal Title
Eur Spine J
Volume: 33
Issue: 1
Pages: 103-110
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Factors associated with cam deformity in Japanese local residents2024
Author(s)
Tomomatsu K, Taniguchi T, Hashizume H, Harada T, Iidaka T, Asai Y, Oka H, Shigeyuki Muraki S, Akune T, Kawaguchi H, Nakamura K, Yoshida M, Tanaka S,Yoshimura N, Yamada H
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Journal Title
Sci Rep
Volume: 14
Issue: 1
Pages: 1585-1585
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Ten-year trends in values of joint space width and osteophyte area of knee joints: Comparison of the baseline and fourth ROAD study surveys2024
Author(s)
Kitamura B, Iidaka T, Horii C, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T, Otsuka Y, Izumo T, Tanaka T, Rogi T, Shibata H, Tanaka S, Yoshimura N
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Journal Title
Osteoarthr Cartil Open
Volume: 6
Issue: 2
Pages: 100454-100454
DOI
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Peer Reviewed / Open Access
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[Journal Article] Trends in the prevalence of atrophic gastritis and Helicobacter pylori infection over a 10-year period in Japan: The ROAD study 2005-20152023
Author(s)
Inoue I, Yoshimura N, Iidaka T, Horii C, Muraki S, Oka H, Kawaguchi H, Akune To, Maekita T, Mure K, Nakamura K, Tanaka S, Ichinose M
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Journal Title
Mol Clin Oncol
Volume: 19
Issue: 1
Pages: 53-53
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Relationship between mddical partite hallux sesamoid and hallux valgus in the general population2023
Author(s)
Higuchi J, Matsumoto T, Kasai T, Takeda R, Iidaka T, Horii C, Oka H, Muraki S, Hashizume H, Yamada H, Yoshida M, Nakamura K, Tanaka S, Yoshimura N
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Journal Title
Foot Ankle Surg
Volume: 29
Issue: 8
Pages: 621-626
DOI
Related Report
Peer Reviewed
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[Journal Article] Do lifestyle, anthropometric and demographic factors associated with muscle strength differ in a UK and Japanese cohort?2023
Author(s)
Dennison EM, Laskou F, Westbury LD, Bevilacqua G, Fuggle NR, Iidaka T, Horii C, Tanaka S, Yoshimura N, Cooper C: Do lifestyle, anthropometric and demographic factors associated with muscle strength differ in a UK and Japanese cohort? An exploratory analysis
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Journal Title
Aging Clin Exp Res
Volume: 35
Issue: 12
Pages: 3097-3104
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Epidemiology of locomotive syndrome using updated clinical decision limits: 6 years follow-ups of the ROAD study2022
Author(s)
Yoshimura N, Iidaka T, Horii C, Mure K, Muraki S. Oka H, Kawaguchi H, Akune T, Ishibashi H, Ohe T, Hashizume H, Yamada H, Yoshida M, Nakamura K, Tanaka S.
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Journal Title
J Bone Miner Metab
Volume: 40
Pages: 623-635
DOI
Related Report
Peer Reviewed
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[Journal Article] Association between acetabular dysplasia and sagittal spino-pelvic alignment in a population-based cohort in Japan2022
Author(s)
Harada T, Hashizume H, Taniguchi T, Iidaka T, Asai Y, Oka H, Muraki S, Akune T, Kawaguchi H, Nakamura K, Yoshida M, Tanaka S, Yoshimura N, Yamada H.
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Journal Title
Sci Rep
Volume: 12
Issue: 1
Pages: 12686-12686
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Is radiographic lumbar spinal stenosis associated with the quality of life?: The Wakayama Spine Study2022
Author(s)
Arita S, Ishimoto Y, Hashizume H, Nagata K, Muraki S, Oka H, Takami M, Tsutsui S, Iwasaki H, Yukawa Y, Akune T, Kawaguchi H, Tanaka S, Nakamura K, Yoshida M, Yoshimura N, Yamada H
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Journal Title
PLOS ONE
Volume: 17
Issue: 2
Pages: e0263930-e0263930
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A Prospective, 3-year Longitudinal Study of Modic Changes of the Lumbar Spine in a Population-based Cohort: The Wakayama Spine Study2022
Author(s)
Tamai H, Teraguchi M, Hashizume H, Oka H, Cheung JPY, Samartzis D, Muraki S, Akune T, Kawaguchi H, Nakamura K, Tanaka S, Yoshida M, Yoshimura N, Yamada H.
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Journal Title
Spine
Volume: 47
Issue: 6
Pages: 490-497
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Epidemiology of locomotive syndrome using updated clinical decision limits: 6-year follow-ups of the ROAD study.2022
Author(s)
Yoshimura N, Iidaka T, Horii C, Mure K, Muraki S, Oka H, Kawaguchi H, Akune T, Ishibashi H, Ohe T, Hashizume H, Yamada H, Yoshida M, Nakamura K, Tanaka S
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Journal Title
Journal of Bone and Mineral Metabolism
Volume: ‐
Related Report
Peer Reviewed
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[Journal Article] Are Japanese older adults rejuvenating? Changes in health-related measures among older community dwellers in the last decade.2021
Author(s)
Suzuki T, Nishita Y, Jeong S, Shimada H, Otsuka R, Kondo K, Kim H, Fujiwara Y, Awata S, Kitamura A, Obuchi S, Iijima K, Yoshimura N, Watanabe S, Yamada M, Toba K, Makizako H
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Journal Title
Rejuvenation Research
Volume: 24(1)
Pages: 37-46
NAID
Related Report
Peer Reviewed
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[Journal Article] Knee osteoarthritis and time-to all-cause mortality in six community-based cohorts: an international meta-analysis of individual participant-level data2021
Author(s)
Leyland KM, Gates LS, Nevitt M, Felson D, Jones G, Jordan JM, Judge A, Sanchez-Santos MT, Sheard S, Yoshimura N, Newton J, Cooper C, Lin J, Liu Q, Collins G, Altman D, Arden NK, and the PCCOA steering committee
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Journal Title
Aging Clinical and Experimental Research
Volume: 33
Issue: 3
Pages: 529-545
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] rends in the prevalence of frailty in Japan: A meta-analysis from the ILSA-J.2020
Author(s)
Makizako H, Nishita Y, Seungwon J, Otsuka R, Shimada H, Iijima K, Obuchi S, Kim H, Kitamura A, Ohara Y, Awata S, Yoshimura N, Yamada M, Toba K, Suzuki T
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Journal Title
The Journal of Frailty & Aging
Volume: -
Issue: 3
Pages: 1-8
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Ten-year differences in the joint space width and osteophyte area of the knee joint: comparison between baseline and the 4th ROAD study surveys. Comparison of baseline and 4th Research on Osteoarthritis/osteoporosis Against Disability study surveys2021
Author(s)
Kitamura B, Iidaka T, Horii C, Muraki S, Oka H, Nakamura K, Akune T, Tanaka T, Rogi T, Shibata H, Tanaka S, Yoshimura N
Organizer
International Osteoporosis Foundation-European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (WCO-IOF-ESCEO 2021)
Related Report
Int'l Joint Research
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