| Co-Investigator(Kenkyū-buntansha) |
GOJOBORI Jun 総合研究大学院大学, 先導科学研究科, 助教 (00506800)
MIYABE Takako 京都大学, 霊長類研究所, 助教 (10437288)
TANABE Hideyuki 総合研究大学院大学, 先導科学研究科, 助教 (50261178)
GO Yasuhiro 大学共同利用機関法人自然科学研究機構(新分野創成センター), 新分野創成センター, 准教授 (50377123)
KOGA Akihiko 京都大学, 霊長類研究所, 教授 (80192574)
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| Budget Amount *help |
¥44,460,000 (Direct Cost: ¥34,200,000、Indirect Cost: ¥10,260,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2011: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2010: ¥22,750,000 (Direct Cost: ¥17,500,000、Indirect Cost: ¥5,250,000)
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| Research Abstract |
We focused on constitutive heterochromatin (RCRO) that positively concerns to rearrangements of genome, and performed molecular dissection and estimated biological meaning of RCRO. We developed a new technique to analyze repetitive sequences and analyzed the component and construction of RCRO. Especially, subterminal satellite and alpha satellite DNA were investigated in chimpanzees, gibbons, and owl monkeys. Incredible differentiations were found in them. We found following results: 1) Gibbons have alpha satellite DNA not only at centromeres but also at telomeres. 2) Owl monkeys showed that 3 structures of alpha satellite DNA are related to change of chromosome number and one of them have some concerns with the nocturnal. 3) Chimpanzees allowed us to postulate that RCRO restrains ectopic recombinations from comparisons with results found previously. These outcomes interestingly enable us to be aware some concerns among biological evolution and chromosome reaaramgements.
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