Chemical Biology on Cancer and Neurodegenerative disease
Project/Area Number |
22310140
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Living organism molecular science
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Research Institution | Keio University |
Principal Investigator |
IMOTO Masaya 慶應義塾大学, 理工学部, 教授 (60213253)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
|
Keywords | CysLT1アンタゴニスト / がん転移 / オートファジー / パーキンソン疾患 / パーキンソン病 / 細胞遊走 / CysLT1 / ケミカルバイオロジー / パーキンソン症 / がん / α-synuclein / 5-リポキシゲナーゼ |
Research Abstract |
1)We showed that SO286 inhibited protein aggregation induced by MPP+ through lysosomal degradation pathway. We attempted to identify the target protein of SO286 responsible for the mechanism of SO286 inhibited the MPP+-induced dot formation and regulation 2)We report that 5-lipoxygenase (5-LOX) is activated and produces leukotriene C4(LTC4) in the process of cell migration, and 5-LOX inhibitors suppressed cell migration. Next, we identified cysteinyl leukotoriene receptor 1 (CysLT1) antagonist also block c
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells2012
Author(s)
Ri M, Tashiro E, Oikawa D, Shinjo S, Tokuda M, Yokouchi Y, Narita T, Masaki A, Ito A, Ding J, Kusumoto S, Ishida T, Komatsu H, Shiotsu Y, Ueda R, Iwawaki T, Imoto M, Iida S
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Journal Title
as a potent inhibitor of ER stress-induced XBP1 mRNA splicing. Blood Cancer J.e
Volume: 79
Related Report
Peer Reviewed
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[Journal Article] Comprehensive Predictions of Target Proteins Based on Protein-Chemical Interaction Using Virtual Screening and Experimental Verifications2012
Author(s)
Kobayashi H, Harada, H, Nakamura M, FutamuraY, Ito A, Yoshida M, Iemura S, Shin-ya K, Doi T, Takahashi T, Natsume T, Imoto Mand Sakakibara Y
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Journal Title
BMC Chemical Biology
Volume: 12
Pages: 2-2
Related Report
Peer Reviewed
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[Journal Article] Antitumor effects of novel highly hydrophilic and non-ATP-competitive MEK1/2 inhibitor2012
Author(s)
Kiga M, Tanzawa F, Iwasaki S, Inaba F, Fujiwara K, IwadareH, Echigo T, Nakamura Y, Shibata T, Suzuki K, Yasumatsu, I Nakayama A, Sasazawa Y, Tashiro E, Imoto M, S. Kurakata S
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Journal Title
SMK-17. Anticancer Drugs.
Volume: 23
Pages: 119-130
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Peer Reviewed
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[Journal Article] Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein2012
Author(s)
Sasazawa, Y., Kanagaki, S., Tashiro, E., Nogawa, T., Muroi, M., Kondoh, Y., Osada, H., Imoto, M
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Journal Title
ACS Chemical Biology
Volume: (in press)
Issue: 5
Pages: 892-900
DOI
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Peer Reviewed
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[Journal Article] Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition2011
Author(s)
Saiki S, Sasazawa Y, Imamichi Y, Kawajiri S, Fujimaki T, Tanida I, Kobayashi H, Sato F, Kei-Ichi Ishikawa, Sato S, Imoto M, Hattori N
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Journal Title
Autophagy
Volume: 7
Pages: 42-53
Related Report
Peer Reviewed
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[Journal Article] Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition.2011
Author(s)
S.Saiki, Y.Sasazawa, Y.Imamichi, S.Kawajiri, T.Fujimaki, I.Tanida, H.Kobayashi, F.Sato, S.Sato, K.Ishikawa, M.Imoto, N.Hattori
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Journal Title
Autophagy
Volume: 7
Pages: 42-53
Related Report
Peer Reviewed
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[Journal Article] Total Synthesis of Incednam, the Aglycon of Incednine2010
Author(s)
T. Ohtani, S. Tsukamoto, H. Kanda, K. Misawa, Y. Urakawa, T. Fujimaki, M. Imoto,Y. Takahashi, D. Takahashi†, and K. Toshima
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Journal Title
Org. Lett
Volume: 12
Pages: 5068-5071
Related Report
Peer Reviewed
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[Journal Article] Isolation and structure elucidation of a novel androgen antagonist2010
Author(s)
Kawamura T, Fujimaki T, Hamanaka N, Torii K, Kobayashi H, Takahashi Y, Igarashi M, Kinoshita N, Nishimura Y, Tashiro E, Imoto M
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Journal Title
arabilin, produced by Streptomycessp. MK756-CF1. J. Antibiot.
Volume: 63
Pages: 601-605
Related Report
Peer Reviewed
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[Journal Article] Glyoxalase-I is a novel target against Bcr-Abl+leukemic cells acquiring stem-like characteristics in hypoxic environment2010
Author(s)
Takeuchi M, Kimura S, Kuroda J, Ashihara E, KawataniM, Osada H, Umezawa K, Yasui E, Imoto M, Tsuruo T, Yokota A, Tanaka R, Nagao T, Nakahata N, Fujiyama Y Maekawa T
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Journal Title
Cell Death Diff.
Volume: 17
Pages: 1211-1220
Related Report
Peer Reviewed
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