Development of a novel therapy for Alzheimer's disease based on vascular modification
Project/Area Number |
22390145
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General internal medicine (including Psychosomatic medicine)
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Research Institution | Osaka University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
SHIMAMURA Munehisa 大阪大学, その他研究科, 准教授 (60422317)
SATO Naoyuki 大阪大学, 医学系研究科, 准教授 (70372612)
NAITO Kozue 独立行政法人医薬基盤研究所, その他部局等 (70373397)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
|
Keywords | ベータ・アミロイド / 炎症 / 血液脳関門 / サイトカイン / 脳血管 / 認知機能 / アルツハイマー病 / 血管 / βアミロイド / 周辺症状 / インターロイキン-6 / 糖尿病 |
Research Abstract |
Development of a novel therapy for Alzheimer’s disease (AD) is needed for our society with increased elderly population. We investigated the involvement of vascular factors in the pathogenesis of AD. We found increased blood-brain barrier vulnerability to systemic inflammation in Alzheimer disease mouse model. We propose the protection of blood-brain barrier form disruption is a possible therapeutic target for AD.
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Report
(4 results)
Research Products
(98 results)
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[Journal Article] HIG1, a novel regulator of mitochondrial γ-secretase, maintains normal mitochondrial function2012
Author(s)
Hayashi H, Nakagami H, Takeichi M, Shimamura M, Koibuchi N, Oiki E, Sato N, Koriyama H, Mori M, Gerardo Araujo R, Maeda A, Morishita R, Tamai K, Kaneda Y
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Journal Title
FASEB J
Volume: (In press)
Related Report
Peer Reviewed
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[Journal Article] Reduction of brain A. by fluvastatin, an HMG-CoA reductase inhibitor, through increase in degradation of APP-CTFs and A. clearance.2010
Author(s)
Mitsuru Shinohara, Naoyuki Sato, Hitomi Kurinami, Daisuke Takeuchi, Shuko Takeda, Munehisa Shimamura, Toshihide Yamashita, Yasuo Uchiyama, Hiromi Rakugi, and Ryuichi Morishita
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Journal Title
The Journal of Biological Chemistry
Volume: 285
Pages: 22091-22102
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[Journal Article] Diabetes accelerated memory dysfunction via cerebrovascular inflammation and A. deposition in an Alzheimer mouse model with diabetes.2010
Author(s)
Shuko Takeda, Naoyuki Sato, Kozue Uchio-Yamada, Kyoko Sawada, Takanori Kunieda, Daisuke Takeuchi, Hitomi Kurinami, Mitsuru Shinohara, Hiromi Rakugi, and Ryuichi Morishita
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Journal Title
Proc Natl Acad Sci USA
Volume: 13, 107
Pages: 7036-41
Related Report
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[Journal Article] Reduction of Brain β-amyloid (Aβ) by fluvastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, thrpugh increase in degradation of amyloid precursor protein C-terminal fragnents (APP-CTFs) and Aβ clearance2010
Author(s)
Shinohara M, Sato N, Kurinami H, Takeuchi D, Takeda S, Shimamura M, Yamashita T, Uchiyama Y, Rakugi H, Morishita R.
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Journal Title
The Journal of Biological Chemistry
Volume: 285
Pages: 22091-102
Related Report
Peer Reviewed
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[Journal Article] Differential Regulation of Amyloid Precursor Protein /Presenilin 1 Interaction during Aβ40/42 Production Detected Using Fusion Constructs.
Author(s)
Naoyuki Sato, Masayasu Okochi, Mitsuru Shinohara, Gopal Thinakaran, Shuko Takeda, Akio Fukumori, Motoko Shinohara-Noma, Mari Mori-Ueda, Hizuki Hamada, Masatoshi Takeda, Hiromi Rakugi, Ryuichi Morishita
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Journal Title
Related Report
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[Presentation] Diabetes increases tau phosphorylation in APP mice: evidence that Abeta is prerequisite, but insufficient to cause tau phosphorylation2013
Author(s)
N Sato, M Mori-Ueda, T Tanaka, S Takeda, K Uchio-Yamada, H Ueda, M Shinohara, S Murayama, M Takeda, H Rakugi, R Morishita
Organizer
The 11th International Conference on Alzheimer's & Parkinson's Diseases AD/PD 2013
Place of Presentation
Italy
Year and Date
2013-03-10
Related Report
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[Presentation] Amyloid precursor protein/presenilin 1 interaction is differentially regulated during Abeta40/42 production: detection using fusion constructs2013
Author(s)
N Sato, M Okochi, M Shinohara, G Thinakaran, S Takeda, A Fukumori, M Shinohara-Noma, M Mori-Ueda, H Hamada, M Takeda, H Rakugi, R Morishita
Organizer
The 11th International Conference on Alzheimer's & Parkinson's Diseases AD/PD 2013
Place of Presentation
Italy
Year and Date
2013-03-09
Related Report
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[Presentation] The mechanisms by which diabetes mellitus increases the risk of Alzheimer's disease2012
Author(s)
Naoyuki Sato, Mari Mori-Ueda, Toshihisa Tanaka, Shuko Takeda, Kozue Uchio-Yamada, Hironori Ueda, Mitsuru Shinohara, Shigeo Murayama, Masatoshi Takeda, Hiromi Rakugi, Ryuichi Morishita
Organizer
Keystone Symposia, Aging and Diseases of Aging
Place of Presentation
Tokyo
Year and Date
2012-10-25
Related Report
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[Presentation] Old APPxob/ob mice showed highly increased level of tau phosphorylation in brain2012
Author(s)
Naoyuki Sato, Mari Mori-Ueda, Toshihisa Tanaka, Shuko Takeda, Kozue Uchio-Yamada, Hironori Ueda, Mitsuru Shinohara, Shigeo Murayama, Masatoshi Takeda, Hiromi Rakugi, Ryuichi Morishita
Organizer
Neuroscience 2012
Place of Presentation
New Orleans
Year and Date
2012-10-15
Related Report
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[Presentation] Roles of beta-amyloid and insulin resistance in the interaction between diabetes mellitus and Alzheimer's disease2012
Author(s)
Naoyuki Sato, Mari Mori-Ueda, Toshihisa Tanaka, Shuko Takeda, Kozue Uchio-Yamada, Hironori Ueda, Mitsuru Shinohara, Shigeo Murayama, Masatoshi Takeda, Hiromi Rakugi, Ryuichi Morishita
Organizer
Gordon Research Conferences, Neurobiology of Brain Disorders
Place of Presentation
Stonehill College
Related Report
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