Analysis of functions of anamorsin, an anti-apoptotic molecule, in hematopoiesis

• Project/Area Number: 22390194
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Osaka University
• Principal Investigator: KANAKURA Yuzuru 大阪大学, 医学系研究科, 教授 (20177489)
• Co-Investigator(Kenkyū-buntansha): ORITANI Kenji 大阪大学, 医学系研究科, 准教授 (70324762) ; MIZUKI Masao 大阪大学, 医学部附属病院, 准教授 (80283761) ; SHIBAYAMA Hirohiko 大阪大学, 医学系研究科, 講師 (60346202)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000); Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
• Keywords: アナモルシン / 遺伝子改変マウス / 造血 / 鉄・硫黄クラスター / ROS / アポトーシス / Picot / 造血幹細胞 / 造血支持細胞 / 鉄硫黄クラスター

Research Abstract

We clarified anamorsin (AM) played important roles on definitive hematopoiesis in both of hematopoietic stem cells and fetal liver stromal cells by using AM deficient fetal liver. Furthermore, we found AM deficiency impaired the iron homeostasis through iron/sulfur protein biogenesis and resulted in the increase of labile iron pool, the accumulation of ROS and the induction of apoptosis.

Research Products

• [Journal Article] C-terminal mutation of RUNX1 attenuates the DNA-damage repair response in hematopoietic stem cells (2012)
  • Author(s): Satoh Y, Matsumura I, Tanaka H, Harada H, Harada Y, Matsui K, Shibata M, Mizuki M, Kanakura Y
  • Journal Title: Leukemia Volume: 26 Pages: 303-311
  • Peer Reviewed
• [Journal Article] NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells (2012)
  • Author(s): Matsui K, Ezoe S, Oritani K, Shibata M, Tokunaga M, Fujita N, Tanimura A, Sudo T, Tanaka H, McBurney MW, Matsumura I, Kanakura Y
  • Journal Title: Biochem Biophys Res Commun Volume: 418 Pages: 811-817
  • Peer Reviewed
• [Journal Article] Recognition of highly restricted regions in the β-propeller domain of αIIb by platelet-associated anti-αIIbβ3 autoantibodies in primary immune thrombocytopenia. (2012)
  • Author(s): Kiyomizu K, Kashiwagi H, Nakazawa T, Tadokoro S, Honda S, Kanakura Y, Tomiyama Y
  • Journal Title: Blood Volume: 120 Pages: 1499-1509
  • Peer Reviewed
• [Journal Article] The endothelial antigen ESAM monitors hematopoietic stem cell status between quiescence and self-renewal (2012)
  • Author(s): Sudo T, Yokota T, Oritani K, Satoh Y, Sugiyama T, Ishida T, Shibayama H, Ezoe S, Fujita N, Tanaka H, Maeda T, Nagasawa T, Kanakura Y
  • Journal Title: J Immunol Volume: 189 Pages: 200-210
  • Peer Reviewed
• [Journal Article] Effect of vasodilators in patient with pulmonary hypertension associated with hemolytic anemia (2012)
  • Author(s): Yoshida A, Mizote I, Sakata Y, Maeda T, Kanakura Y, Yamauchi-Takihara K, Komuro I
  • Journal Title: J Cardiol Cases Volume: 6
  • Peer Reviewed
• [Journal Article] Deregulated expression of HMGA2 is implicated in clonal expansion of PIGA deficient cells in paroxysmal nocturnal haemoglobinuria (2012)
  • Author(s): Murakami Y, Inoue N, Shichishima T, Ohta R, Noji H, Maeda Y, Nishimura JI, Kanakura Y, Kinoshita T
  • Journal Title: Br J Haematol Volume: 156 Pages: 383-387
  • Peer Reviewed
• [Journal Article] C-terminal mutation of RUNX1 attenuates the DNA-damage repair response in hematopoietic stem cells (2012)
  • Author(s): Satoh Y, Mizuki M, Kanakura Y, et al
  • Journal Title: Leukemia Volume: 26(2) Issue: 2 Pages: 303-311
  • DOI: 10.1038/leu.2011.202
  • Peer Reviewed
• [Journal Article] The Endothelial Antigen ESAM Monitors Hematopoietic Stem Cell Status between Quiescence and Self-Renewal. (2012)
  • Author(s): Sudo, T.
  • Journal Title: J. Immunol. Volume: 189 Issue: 1 Pages: 200-210
  • DOI: 10.4049/jimmunol.1200056
  • Peer Reviewed
• [Journal Article] NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells (2012)
  • Author(s): Matsui K, Ezoe S, McBurney M W, Matsumura I, Kanakura Y
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 418 Issue: 4 Pages: 811-817
  • DOI: 10.1016/j.bbrc.2012.01.109
  • Peer Reviewed
• [Journal Article] STAP-2 interacts with and modulates BCR-ABL-mediated tumorigenesis (2012)
  • Author(s): Sekine Y, Kanakura Y, Sekine Y, Kanakura Y, Oritani K, Matsuda T, et al
  • Journal Title: Oncogene Volume: 10 Issue: 40 Pages: 1038-1038
  • DOI: 10.1038/onc.2011.604
  • Peer Reviewed
• [Journal Article] Deregulated expression of HMGA2 is implicated in clonal expansion of PIGA deficient cells in paroxysmal nocturnal haemoglobinuria (2012)
  • Author(s): Murakami, Y., N. Inoue, T. Shichishima, R. Ohta, H. Noji, Y. Maeda, J. Nishimura, Y. Kanakura and T. Kinoshita
  • Journal Title: Br. J. Haematol Volume: 156 Issue: 3 Pages: 383-387
  • DOI: 10.1111/j.1365-2141.2011.08914.x
  • Peer Reviewed
• [Journal Article] A lower starting dose of eltrombopag is efficacious in Japanese patients with previously treated chronic immune thrombocytopenia. (2012)
  • Author(s): Y Tomiyama
  • Journal Title: J Thromb Haemost Volume: 10 Issue: 5 Pages: 799-806
  • DOI: 10.1111/j.1538-7836.2012.04695.x
  • Peer Reviewed
• [Journal Article] Safety and efficacy of the terminal complement inhibitor eculizumab in Japanese patients with paroxysmal nocturnal hemoglobinuria: the AEGIS Clinical Trial (2011)
  • Author(s): Kanakura Y, Ohyashiki K, Shichishima T, Okamoto S, Ando K, Ninomiya H, Kawaguchi T, Nakao S, Nakakuma H, Nishimura J, Kinoshita T, Bedrosian CL, Valentine ME, Khursigara G, Ozawa K, Omine M
  • Journal Title: Int J Hematol Volume: 93 Pages: 36-46
  • NAID: 10029532438
  • Peer Reviewed
• [Journal Article] A potential role for α-actinin in inside-out αIIbβ3 signaling. (2011)
  • Author(s): Tadokoro S, Nakazawa T, Kamae T, Kiyomizu K, Kashiwagi H, Honda S, Kanakura Y, Tomiyama Y
  • Journal Title: Blood Volume: 117 Pages: 250-258
  • Peer Reviewed
• [Journal Article] Identification of functional domains and novel binding partners of STIM proteins (2011)
  • Author(s): Saitoh N, Oritani K, Saito K, Yokota T, Ichii M, Sudo T, Fujita N, Nakajima K, Okada M, Kanakura Y
  • Journal Title: J Cell Biochem Volume: 112 Pages: 147-156
  • Peer Reviewed
• [Journal Article] Predictability of the response to tyrosine kinase inhibitors via in vitro analysis of Bcr-Abl phosphorylation (2011)
  • Author(s): Shibata M, Ezoe S, Oritani K, Matsui K, Tokunaga M, Fujita N, Saito Y, Takahashi T, Hino M, Matsumura I, Kanakura Y
  • Journal Title: Leuk Res Volume: 35 Pages: 1205-1211
  • Peer Reviewed
• [Journal Article] Myeloid neoplasm-related gene abnormalities differentially affect dendritic cell differentiation from murine hematopoietic stem/progenitor cells (2011)
  • Author(s): Fujita J, Mizuki M, Otsuka M, Ezoe S, Tanaka H, Satoh Y, Fukushima K, Tokunaga M, Matsumura I, Kanakura Y
  • Journal Title: Immunol Lett Volume: 136 Pages: 61-73
  • Peer Reviewed
• [Journal Article] Constitutive active FGFR3 Lys650Glu mutation enhances the bortezomib-sensitivity in plasma cell malignancy (2011)
  • Author(s): Otsuka M, Mizuki M, Fujita J, Kang S, Kanakura Y
  • Journal Title: Anticancer Res Volume: 31 Pages: 113-122
  • Peer Reviewed
• [Journal Article] A cell-death-defying factor, anamorsin mediates cell growth through inactivation of PKC and p38MAPK (2011)
  • Author(s): Saito Y, Shibayama H, Tanaka H, Tanimura A, Kanakura Y
  • Journal Title: Biochem Biophys Res Commun Volume: 405 Pages: 303-307
  • Peer Reviewed
• [Journal Article] PICOT is a molecule which binds to anamorsin (2011)
  • Author(s): Saito Y, Shibayama H, Tanaka H, Tanimura A, Matsumura I, Kanakura Y
  • Journal Title: Biochem Biophys Res Commun Volume: 408 Pages: 329-333
  • Peer Reviewed
• [Journal Article] Bleeding tendency and impaired platelet function in a patient carrying a heterozygous mutation in the thromboxane A2 receptor (2011)
  • Author(s): Kamae T, Kiyomizu K, Nakazawa T, Tadokoro S, Kashiwagi H, Honda S, Kanakura Y, Tomiyama Y
  • Journal Title: J Thromb Haemost Volume: 9 Pages: 1040-1048
  • Peer Reviewed
• [Journal Article] Safety and efficacy of the terminal complement inhibitor eculizumab in Japanese patients with paroxysmal nocturnal hemoglobinuria : the AEGIS Clinical Trial (2011)
  • Author(s): Kanakura Y, Ohyashiki K, Shichishima T, et al
  • Journal Title: Int J Hematol Volume: 93 Pages: 36-46
  • NAID: 10029532438
  • Peer Reviewed
• [Journal Article] A potential role for α-actinin in inside-out αIIbss3 signaling (2011)
  • Author(s): Tadokoro S, Nakazawa T, Kanakura Y, et al
  • Journal Title: Blood Volume: 117 Pages: 250-258
  • Peer Reviewed
• [Journal Article] Molecular analysis of a patient with type I Glanzmann throm basthenia and clinical impact of the presence of anti-αIIbss3 a lloantibodies (2011)
  • Author(s): Kashiwagi H, Kiyomizu K, Kanakura Y, et al
  • Journal Title: Int J Hematol Volume: 93 Pages: 106-111
  • Peer Reviewed
• [Journal Article] Constitutively active FGFR3 Lys650Glu mutation enhances the bortezomib-sensitivity in plasma cell malignancy (2011)
  • Author(s): Otsuka M, Mizuki M, Kanakura Y, et al
  • Journal Title: Anticancer Res Volume: 31 Pages: 113-122
  • Peer Reviewed
• [Journal Article] Bleeding tendency and impaired platelet function in a patient carrying a heterozygous mutation in the thromboxane A2 receptor (2011)
  • Author(s): Kamae T, Kiyomizu K, Nakazawa T, Tadokoro S, Kashiwagi H, Honda S, Kanakura Y, Tomiyama Y.
  • Journal Title: J Thromb Haemost Volume: 9 Issue: 5 Pages: 1040-1048
  • DOI: 10.1111/j.1538-7836.2011.04245.x
  • Peer Reviewed
• [Journal Article] Presence of B-cell clones in T-cell lymphoma (2011)
  • Author(s): Zaki MA, Wada N, Kanakura Y, et al
  • Journal Title: Eur J Haematol Volume: 86 Issue: 5 Pages: 412-419
  • DOI: 10.1111/j.1600-0609.2011.01597.x
  • Peer Reviewed
• [Journal Article] Constitutively active FGFR3 with Lys650Glu mutation enhances bortezomib sensitivity in plasma cell malignancy. (2011)
  • Author(s): Otsuka M, Mizuki M, Fujita J, Kang S, Kanakura Y.
  • Journal Title: Anticancer Res. Volume: 31(1) Pages: 113-122
  • Peer Reviewed
• [Journal Article] Safety and efficacy of the terminal complement inhibitor eculizumab in Japanese patients with paroxysmal nocturnal hemoglobinuria : the AEGIS clinical trial. (2011)
  • Author(s): Kanakura Y, et al.
  • Journal Title: Int J Hematol. Volume: 93(1) Pages: 36-46
  • NAID: 10029532438
  • Peer Reviewed
• [Journal Article] A cell-death-defying factor, anamorsin mediates cell growth through inactivation of PKC and p38MAPK. (2011)
  • Author(s): Saito Y, Shibayama H, Kanakura Y, et al.
  • Journal Title: Biochem Biophys Res Commun. Volume: 405(2) Pages: 303-307
  • Peer Reviewed
• [Journal Article] Identification of functional domains and novel binding partners of STIM proteins. (2011)
  • Author(s): Saitoh N, Oritani K, Kanakura Y, et al.
  • Journal Title: J Cell Biochem. Volume: 112(1) Pages: 147-156
  • Peer Reviewed
• [Journal Article] A potential role for α-actin in in inside-out αIIbβ3 signaling. (2011)
  • Author(s): Tadokoro S, Kanakura Y, et al.
  • Journal Title: Blood. Volume: 117(1) Pages: 250-258
  • Peer Reviewed
• [Journal Article] BCR-ABL but not JAK2 V617F inhibits erythropoiesis through the Ras signal by inducing p21CIP1/WAF1 (2010)
  • Author(s): Tokunaga M, Ezoe S, Tanaka H, Satoh Y, Fukushima K, Matsui K, Shibata M, Tanimura A, Oritani K, Matsumura I, Kanakura Y
  • Journal Title: J Biol Chem Volume: 285 Pages: 31774-31782
  • Peer Reviewed
• [Journal Article] Stromal cell-free conditions favorable for human B lymphopoiesis in culture. (2010)
  • Author(s): Ichii M, Oritani K, Yokota T, Schultz DC, Holter JL, Kanakura Y, Kincade PW
  • Journal Title: J Immunol Methods Volume: 359 Pages: 47-55
  • Peer Reviewed
• [Journal Article] The density of CD10 corresponds to commitment and progression in the human B lymphoid lineage (2010)
  • Author(s): Ichii M, Oritani K, Yokota T, Zhang Q, Garrett KP, Kanakura Y, Kincade PW
  • Journal Title: PLoS One Volume: 5
  • Peer Reviewed
• [Journal Article] Diffuse large B-cell lymphoma in the spinal epidural space: A study of the Osaka Lymphoma Study Group (2010)
  • Author(s): Wada N, Kohara M, Ikeda J, Hori Y, Fujita S, Okada M, Ogawa H, Sugiyama H, Fukuhara S, Kanamaru A, Hino M, Kanakura Y, Morii E, Aozasa K
  • Journal Title: Pathol Res Pract Volume: 206 Pages: 439-444
  • Peer Reviewed
• [Journal Article] BCR-ABL but not JAK2 V617F inhibits erythropoiesis through the Ras signal by inducing p21^<CIP1/WAF1>. (2010)
  • Author(s): Tokunaga M, Kanakura Y, et al.
  • Journal Title: J Biol Chem. Volume: 285 Pages: 31774-31782
  • Peer Reviewed
• [Journal Article] Stromal cell-free conditions favorable for human B lymphopoiesis in culture. (2010)
  • Author(s): Ichii M, Oritani K, Kanakura Y, et al.
  • Journal Title: J Immunol Methods. Volume: 359 Pages: 47-55
  • Peer Reviewed
• [Journal Article] The density of CD10 corresponds to commitment and progression in the human B lymphoid lineage. (2010)
  • Author(s): Ichii M, Oritani K, Kanakura Y, et al.
  • Journal Title: PLoS One. Volume: 5
  • Peer Reviewed
• [Journal Article] Imatinib for newly diagnosed chronic-phase chronic myeloid leukemia : results of a prospective study in Japan. (2010)
  • Author(s): Nagai T, Kanakura Y, et al.
  • Journal Title: Int J Hematol. Volume: 92 Pages: 111-117
  • NAID: 10026512176
  • Peer Reviewed
• [Journal Article] Polymorphous lymphoproliferative disorder : a clinicopathological analysis. (2010)
  • Author(s): Nakamichi N, Kanakura Y, et al.
  • Journal Title: Virchows Arch. Volume: 456 Pages: 269-276
  • Peer Reviewed
• [Journal Article] Diffuse large B-cell lymphoma in the spinal epidural space : A study of the Osaka Lymphoma Study Group. (2010)
  • Author(s): Wada N, Kanakura Y, et al.
  • Journal Title: Pathol Res Pract. Volume: 206 Pages: 439-444
  • Peer Reviewed
• [Journal Article] Peripheral T-cell lymphoma of Lennert type complicated by monoclonal proliferation of lrge B-cells. (2010)
  • Author(s): Chihara T, Shibayama H, Kanakura Y, et al.
  • Journal Title: Pathol Res Pract. Volume: 206 Pages: 185-190
  • Peer Reviewed
• [Journal Article] Pulmonary hypertension associated with bone marrow transplantaion. (2010)
  • Author(s): Nakaoka H, Kanakura Y, et al.
  • Journal Title: J Cardiol cases. Volume: 2 Pages: 23-27
  • Peer Reviewed
• [Journal Article] The efficacy of tocilizumab in a patient with pulmonary arterial hypertension associated with Castleman's disease. (2010)
  • Author(s): Arita Y, Kanakura Y, et al.
  • Journal Title: Heart Vessels. Volume: 25 Pages: 444-447
  • Peer Reviewed
• [Journal Article] BS69 cooperates with TRAF3 in the regulation of Epstein-Barr virus-derived LMP1/CTAR1-induced NF-kappaB activation. (2010)
  • Author(s): Ikeda O, Oritani K, et al.
  • Journal Title: FEBS Lett. Volume: 584 Pages: 865-872
  • Peer Reviewed
• [Journal Article] Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells. (2010)
  • Author(s): Ikeda O, Oritani K, et al.
  • Journal Title: J Biol Chem. Volume: 285 Pages: 38093-38103
  • Peer Reviewed
• [Journal Article] Prognostic factors and outcomes of adult patients with acute myeloid leukemia after first relapse. (2010)
  • Author(s): Kurosawa S, Shibayama H, et al.
  • Journal Title: Haematologica. Volume: 95 Pages: 1857-1864
  • Peer Reviewed
• [Journal Article] 骨髄増殖性疾患の概念 (2010)
  • Author(s): 金倉譲
  • Journal Title: 臨床検査 Volume: 54 Pages: 227-233
• [Journal Article] 総論:白血病治療の進歩-特集に寄せて- (2010)
  • Author(s): 金倉譲
  • Journal Title: BIO Clinica Volume: 25 Pages: 16-17
• [Journal Article] 肥満細胞症の病態と治療 (2010)
  • Author(s): 水木満佐央, 金倉譲
  • Journal Title: 血液・腫瘍科 Volume: 61 Pages: 177-183
  • NAID: 40021100024
• [Journal Article] 発作性夜間ヘモグロビン尿症の病態と治療 (2010)
  • Author(s): 西村純一, 金倉譲
  • Journal Title: 日本医事新報 Volume: 4520 Pages: 45-49
  • NAID: 40017391894
• [Journal Article] Primary effusion lymphomaの発症機序と治療の進歩 (2010)
  • Author(s): 池田純一郎, 水木満佐央, 金倉譲
  • Journal Title: 血液・腫瘍科 Volume: 61 Pages: 307-312
• [Presentation] An anti-apoptotic molecule, Anamorsin, is essential for erythropoiesis through the regulation of cellular labile iron pool. (2012)
  • Author(s): Tanimura A, Hamanaka Y, Fujita N, Doi Y, Ishibashi T, Sudo T, Matsui K, Ichii M, Saitoh N, Satoh Y, Ezoe S, Yokota T, Oritani K, Shibayama H, Kanakura Y
  • Organizer: The American Society of Hematology 54th Annual Meeting
  • Place of Presentation: Atlanta, USA
  • Year and Date: 2012-12-10
• [Presentation] A rare genetic polymorphism in C5 confers poor response to the anti-C5 monoclonal antibody eculizumab by nine Japanese patients with PNH (2012)
  • Author(s): Nishimura J, Yamamoto M, Hayashi S, Ohyashiki K, Ando K, Noji H, Kitamura K, Eto T, Ando T, Masuko M, Shibayama H, Hase M, Lan L, Tamburini P, Inazawa J, Kinoshita T, Kanakura Y
  • Organizer: The American Society of Hematology 54th Annual Meeting
  • Place of Presentation: Atlanta, USA
  • Year and Date: 2012-12-10
• [Presentation] An anti-apoptotic molecule, Anamorsin, functions in both Fe/S cluster assembly and iron homeostasis. (2012)
  • Author(s): Tanimura A, Hamanaka Y, Tanaka H, Matsumura I, Ishibashi T, Sudo T, Satoh Y, Yokota T, Ezoe S, Oritani K, Shibayama H, Kanakura Y
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2012-10-20
• [Presentation] Role of endothelial antigen ESAM in hematopoietic stem cells status (2012)
  • Author(s): Sudo T, Yokota T, Oritani K, Satoh Y, Sugiyama T, Ishida T, Shibayama H, Ezoe S, Ichii M, Tanimura A, Fujita N, Ishibashi T, Matsui K, Hamanaka Y, Nagasawa T, Kanakura Y
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2012-10-20
• [Presentation] Significance of novel HSC marker ESAM expression in cord blood (2012)
  • Author(s): Ishibashi T, Yokota T, Satoh Y, Sudo T, Ichii M, Shibayama H, Ezoe S, Tanimura A, Fujita N, Matsui K, Hamanaka Y, Oritani K, Kanakura Y
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2012-10-19
• [Presentation] Identification of osteoblast stimulating factor-5 as a novel regulator of early lymphocyte development (2012)
  • Author(s): Fujita N, Oritani K, Yokota T, Saito N, Sudo T, Yamawaki K, Kanakura Y
  • Organizer: The 17th Congress of the European Hematology Association
  • Place of Presentation: Amsterdam,Netherlands
  • Year and Date: 2012-06-15
• [Presentation] Involvement of STAP-2 in BCR-ABL-mediated signals for CML development (2012)
  • Author(s): Oritani K, Sekine Y, Muromoto R, Fujita N, Matsuda T, Kanakura Y
  • Organizer: 第3回日本血液学会(JSH)国際シンポジウム
  • Place of Presentation: 埼玉
  • Year and Date: 2012-05-26
• [Presentation] Satb1 promotes hematopoietic stem cell differentiation toward the lymphoid lineages (2011)
  • Author(s): Satoh Y, Yokota T, Kondo M, Lai A, Kincade P, Kouro T, Iida R, Kokame K, Miyata T, Sudo T, Tanaka H, Matsumura I, Oritani K, Kohwi-Shigematsu T, Kanakura Y
  • Organizer: The American Society of Hematology 53rd Annual meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2011-12-10
• [Presentation] An anti-apoptotic molecule, Anamorsin, functions in both iron-sulfur protein assembly and cellular iron homeostasis (2011)
  • Author(s): Tanimura A, Kondo Y, Tanaka H, Matsumura I, Ishibashi T, Sudo T, Satoh Y, Yokota T, Ezoe S, Oritani K, Shibayama H, Kanakura Y
  • Organizer: The American Society of Hematology 53rd Annual meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2011-12-10
• [Presentation] The endothelial antigen ESAM monitors reversible conversion of hematopoietic stem cells between dormancy and self-renewal (2011)
  • Author(s): Sudo T, Yokota T, Sugiyama T, Ishida T, Satoh Y, Oritani K, Nagasawa T, Kanakura Y
  • Organizer: The American Society of Hematology 53rd Annual meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2011-12-10
• [Presentation] Satb1 promotes hematopoietic stem cell differentiation toward the lymphoid lineages (2011)
  • Author(s): Satoh Y, Yokota T, Kanakura Y, et al
  • Organizer: The American Society of Hematology 53rd Annual meeting
  • Place of Presentation: San Diego Convention Center (USA)
  • Year and Date: 2011-12-10
• [Presentation] An anti-apoptotic molecule, Anamorsin, functions in both iron-sulfur protein assembly and cellular iron homeostasis (2011)
  • Author(s): Tanimura A, Kondo Y, Shibayama H, Kanakura Y, et al
  • Organizer: The American Society of Hematology 53rd Annual meeting
  • Place of Presentation: San Diego Convention Center (USA)
  • Year and Date: 2011-12-10
• [Presentation] Satb1 directs hematopoietic stem cell differentiation toward the lymphoid lineages (2011)
  • Author(s): Yokota T, Satoh Y, Kondo M, Kincade PW, Kouro T, Iida R, Sudo T, Tanaka H, Matsumura I, Oritani K, Kohwi-Shigematsu T, Kanakura Y
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-27
• [Presentation] SATB1 induces early lymphocyte differentiation from primitive hematopoietic progenitors (2011)
  • Author(s): Satoh Y, Yokota T, Tanaka H, Kokame K, Miyata T, Matsumura I, Oritani K, Kanakura Y
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 愛知
  • Year and Date: 2011-10-14
• [Presentation] Predictability of the response to tyrosine kinase inhibitors via in vitro analysis of Bcr-Abl signal (2011)
  • Author(s): Shibata M, Ezoe S, Matsui K, Satoh Y, Tanimura A, Matsumura I, Oritani K, Kanakura Y
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 愛知
  • Year and Date: 2011-10-14
• [Presentation] SATB1 induces early lymphocyte differentiation from primitive hematopoietic progenitors (2011)
  • Author(s): Satoh Y, Yokota T, Kanakura Y, et al
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2011-10-14
• [Presentation] Clinical prognostic analysis of 465 follicular lymphoma (FL) cases from OLSG (Osaka Lymphoma study Group) registry : OLSG cohort analysis (2011)
  • Author(s): 小原尚恵, 柴山浩彦, 金倉譲, ほか
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2011-10-14
• [Presentation] Predictability of the response to tyrosine kinase inihibitors via in vitro analysis of Bcr-Abl signal (2011)
  • Author(s): Shibata M, Ezoe S, Kanakura Y, et al
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2011-10-03
• [Presentation] 当科における悪性リンパ腫に対するDeVIC療法施行例の後方視的検討 (2011)
  • Author(s): 大塚正恭, 前田哲生, 金倉譲, ほか
  • Organizer: 第9回日本臨床腫瘍学会学術集会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2011-07-21
• [Presentation] Energy metabolism of glucose and ATP affects the growth and differentiation of hematopoietic stem/progenitor cells (2011)
  • Author(s): Matsui K, Ezoe S, Shibata M, Otsuka M, Oritani K, Kanakura Y
  • Organizer: The 16th Congress of the European Hematology Association
  • Place of Presentation: London, UK
  • Year and Date: 2011-06-09
• [Presentation] Constitutive active FGFR3 Lys650Glu mutation enhances the bortezomib-sensitivity in plasma cell malignancy (2011)
  • Author(s): Otsuka M, Mizuki M, Fujita J, Kang S, Kanakura Y
  • Organizer: The 16th Congress of the European Hematology Association
  • Place of Presentation: London, UK
  • Year and Date: 2011-06-09
• [Presentation] (Educational lecture) Recent advance in the treatment of paroxysmal nocturnal hemoglobinuria (PNH) : Japanese experience on eculizumab (2011)
  • Author(s): Kanakura Y
  • Organizer: The 52nd Spring Meeting of the Korean Society of Hematology
  • Place of Presentation: Seoul, Korea(招待講演)
  • Year and Date: 2011-05-27
• [Presentation] (Educational lecture) Recent advance in pathophysiology and treatment of paroxysmal nocturnal hemoglobinuria (PNH) : the efficacy and safety profiles of eculizumab in Japanese patients with PNH (2011)
  • Author(s): Kanakura Y
  • Organizer: The Taiwan Society of Hematology
  • Place of Presentation: Taipei/Taoyuan County, Taiwan(招待講演)
  • Year and Date: 2011-04-16
• [Presentation] A cell-death-defying factor, anamorsin, contributes cell growth through binding with PICOT and inactivation of PKCs and p38MAPK (2010)
  • Author(s): Shibayama H, Saito Y, Tanimura A, Tanaka H, Matsumura I, Kanakura Y
  • Organizer: The American Society of Hematology 52nd Annual meeting
  • Place of Presentation: Orlando, USA
  • Year and Date: 2010-12-04
• [Presentation] A chromatin modifier SATB1 promotes lymphocyte production from primitive hematopoietic stem/ progenitor cells. (2010)
  • Author(s): Satoh Y, Yokota T, Tanaka H, Kokame K, Miyata T, Matsumura I, Oritani K, Kanakura Y
  • Organizer: The American Society of Hematology 52nd Annual meeting
  • Place of Presentation: Orlando, USA
  • Year and Date: 2010-12-04
• [Presentation] 骨髄不全の診断と治療 (2010)
  • Author(s): 金倉 譲
  • Organizer: 第42回日本内科学会近畿生涯教育講演会
  • Place of Presentation: 大阪
  • Year and Date: 2010-06-20
• [Presentation] 骨髄不全の診断と治療 (2010)
  • Author(s): 金倉譲
  • Organizer: 第42回日本内科学会 近畿生涯教育講演会
  • Place of Presentation: 大阪国際会議場、大阪(招待講演)
  • Year and Date: 2010-06-20
• [Presentation] Fatigue and impared quality of life in patients with paroxysmal nocturnal hemoglobinuria (PNH) is associated with hemolysis, but not with anemia. (2010)
  • Author(s): Kanakura Y, Ohyashiki K, Shichishima T, Okamoto S, Ando K, Ninomiya H, Kawaguchi T, Nakao S, Nakakuma H, Nishimura J, Kinoshita T, Bedrosian C, Valentine ME, Ozawa K, Omine M
  • Organizer: The 15th Congress of the European Hematology Association
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-06-10
• [Presentation] Essential role of an anti-apoptotic molecule Anamorsin for both intrinsic and extrinsic regulation of murine fetal liver hematopoiesis (2010)
  • Author(s): Tanimura A, Tanaka H, Saito Y, Shibayama H, Matsumura I, Kanakura Y
  • Organizer: The 15th Congress of the European Hematology Association
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-06-10
• [Presentation] Fatigue and impared quality of life in patients with paroxysmal nocturnal hemoglobinuria (PNH) is associated with hemolysis, but not with anemia (2010)
  • Author(s): Kanakura Y, et al.
  • Organizer: 15th Congress of the European Hematology Association
  • Place of Presentation: BICC, Barcelona (Spain)
• [Presentation] BCR-ABL but not JAK2 V617F inhibits erythropoiesis through the Ras signal by inducing p21^<CIP1/WAF1> (2010)
  • Author(s): Tokunaga M, Kanakura Y, et al.
  • Organizer: 15th Congress of the European Hematology Association
  • Place of Presentation: BICC, Barcelona (Spain)
• [Presentation] Essential role of an anti-apoptotic molecule Anamorsin for both intrinsic and extrinsic regulation of murine fetal liver hematopoiesis (2010)
  • Author(s): Tanimura A, Shibayama H, Kanakura Y, et al.
  • Organizer: 15th Congress of the European Hematology Association
  • Place of Presentation: BICC, Barcelona (Spain)
• [Presentation] Excessive reactive iron affects both immature hematopoietic cells and stromal cells, thereby impairing total hematopoiesis (2010)
  • Author(s): Tanaka H, Kanakura Y, et al.
  • Organizer: 1st JSH International Symposium
  • Place of Presentation: Akita University, Akita
• [Presentation] C-terminal mutation of RUNX1 deteriorates DNA damage-repair response and promotes the development of AML (2010)
  • Author(s): Satoh Y, Kanakura Y, et al.
  • Organizer: The 17th International RUNX Workshop
  • Place of Presentation: Oriental Hotel Hiroshima, Hiroshima
• [Presentation] A cell-death-defying factor, anamorsin, contributes cell growth through binding with PICOT and inactivation of PKCs and p38MAPK (2010)
  • Author(s): Shibayama H, Kanakura Y, et al.
  • Organizer: The American Society of Hematology 52nd Annual meeting
  • Place of Presentation: OCCC, Orlando(USA)
• [Presentation] A chromatin modifier SATB1 promotes lymphocyte production from primitive hematopoietic stem/progenitor cells (2010)
  • Author(s): Satoh Y, Oritani K, Kanakura Y, et al.
  • Organizer: The American Society of Hematology 52nd Annual meeting
  • Place of Presentation: OCCC, Orlando (USA)
• [Presentation] Bleeding tendency and impaired platelet function in a patient carrying a heterozygous mutation in thromboxane A2 receptor (2010)
  • Author(s): Kamae T, Kanakura Y, et al.
  • Organizer: The American Society of Hematology 52nd Annual meeting
  • Place of Presentation: OCCC, Orlando (USA)
• [Presentation] Myeloid neoplasm-related gene abnormalities differentially affect FLT3-ligand mediated dendritic cell differentiation from murine hematopoietic stem/progenitor cells (2010)
  • Author(s): Fujita J, Mizuki M, Kanakura Y, et al.
  • Organizer: The American Society of Hematology 52nd Annual meeting
  • Place of Presentation: OCCC, Orlando (USA)
• [Presentation] Evaluation of paroxysmal nocturnal hemoglobinuria disease burden : The patient's perspective. A report from the International PNH registry (2010)
  • Author(s): Muus P, Kanakura Y, et al.
  • Organizer: The American Society of Hematology 52nd Annual meeting
  • Place of Presentation: OCCC, Orlando (USA)
• [Presentation] Use of blood transfusion in paroxysmal nocturnal hemoglobinuria patients with and without aplastic anemia enrolled in the global PNH registry (2010)
  • Author(s): Schrezenmeier H, Kanakura Y, et al.
  • Organizer: The American Society of Hematology 52nd Annual meeting
  • Place of Presentation: OCCC, Orlando (USA)
• [Presentation] Expression of HMGA2 in blood cells from patients with paroxysmal nocturnal hemoglobinuria (2010)
  • Author(s): Murakami Y, Kanakura Y, et al.
  • Organizer: The American Society of Hematology 52nd Annual meeting
  • Place of Presentation: OCCC, Orlando (USA)
• [Presentation] Central nervous system events in patients with diffuse large B-cell lymphoma in the rituximab era (2010)
  • Author(s): Tomita N, Shibayama H, et al.
  • Organizer: The American Society of Hematology 52nd Annual meeting
  • Place of Presentation: OCCC, Orlando (USA)
• [Presentation] Efficacy and safety of nilotinib in chronic phase (CP) chronic myeloid leukemia (CML) patients (Pts) with type 2 diabetes in the ENESTnd trial (2010)
  • Author(s): Saglio G, Shibayama H, et al.
  • Organizer: The American Society of Hematology 52nd Annual meeting
  • Place of Presentation: OCCC, Orlando (USA)
• [Presentation] Effects of iron-overload on normal hematopoiesis and disease progression of myeloid malignancies (2010)
  • Author(s): Tanaka H, Kanakura Y, et al.
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場、大阪
• [Presentation] Combination therapy with Nilotinib and Gefitinib for adenocarcinoma of lung following chronic myelogenous leukemia (2010)
  • Author(s): Fukushima K, Mizuki M, Kanakura Y, et al.
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場、大阪
• [Presentation] Leukemia-related gene abnormalities affect steady-state dendritic cell differentiation (2010)
  • Author(s): 藤田二郎, 水木満佐央, 金倉譲, 他
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場、大阪
• [Presentation] The activated Ras signal suppresses erythropoiesis downstream of Bcr-Abl by inducing p21^<CIP1/WAF1> (2010)
  • Author(s): 徳永正浩, 金倉譲, 他
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場、大阪
• [Presentation] A cell-death defying factor, anamorsin, yields cell growth through inactivation of p38MAPK (2010)
  • Author(s): 齋藤有理, 柴山浩彦, 金倉譲, 他
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場、大阪
• [Presentation] Eltronbopag is efficacious in Japanese patients with previously treated chronic ITP (2010)
  • Author(s): 冨山佳昭, 金倉譲, 他
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜、神奈川
• [Presentation] Efficacy and safety of nilotinib versus imatinib in Japanese patients with newly diagnosed CML-CP (2010)
  • Author(s): Shibayama H, et al.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜、神奈川
• [Presentation] Ironoverload impairs normal hematopoiesis and would contribute to disease progression of MDS (2010)
  • Author(s): Tanaka H, Kanakura Y, et al.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜、神奈川
• [Presentation] Leukemia-related gene abnormalities affect FLT3-ligand-mediated dendritic cell differentiation (2010)
  • Author(s): 藤田二郎, 水木満佐央, 金倉譲, 他
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜、神奈川
• [Presentation] BCR-ABLは下流のRasシグナルを介して赤芽球造血を抑制し、その抑制にはp21CIP1/WAF1が関与する (2010)
  • Author(s): 徳永正浩, 金倉譲, 他
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜、神奈川
• [Presentation] Anti-apoptotic molecule Anamorsin is crucial for stromal function to support embryonic hematopoiesis (2010)
  • Author(s): Tanimura A, Shibayama H, Kanakura Y, et al.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜、神奈川
• [Presentation] Safety and efficiency of VAD-BD switched protocol for patients with multiple myeloma (2010)
  • Author(s): Hasei H, kanakura Y, et al.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜、神奈川
• [Presentation] Change of BCR-ABL levels during nilotinib and imatinib treatment for newly diagnosed CML-CP (2010)
  • Author(s): Imai Y, Shibayama H, et al.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜、神奈川
• [Presentation] Clinical significance of WT1 mRNA expression level in patients with myelodysplastic syndrome(MDS) (2010)
  • Author(s): Nannya Y, Shibayama H, et al.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜、神奈川
• [Presentation] Platelet-associated anti-GPIIb/IIIa autoantibodies in primary immune thrombocytopenia recognize highly restricted regions in the beta-propeller domain of GPIIb with clonality
  • Author(s): K Kiyomizu
  • Organizer: The 17th Congress of the European Hematology Association
  • Place of Presentation: Amsterdam, Netherlands
• [Presentation] Identification of osteoblast stimulating factor-5 as a novel regulator of early lymphocyte development
  • Author(s): N Fujita
  • Organizer: The 17th Congress of the European Hematology Association
  • Place of Presentation: Amsterdam, Netherlands
• [Presentation] Crucial role of complement receptor type 1 on the accumulation of complement component 3 on erythrocytes in patients with PNH treated with eculizumab
  • Author(s): M Yamamoto
  • Organizer: The American Society of Hematology 54th Annual Meeting
  • Place of Presentation: Atlanta, USA
• [Presentation] An anti-apoptotic molecule, Anamorsin, is essential for erythropoiesis through the regulation of cellular labile iron pool
  • Author(s): A Tanimura
  • Organizer: The American Society of Hematology 54th Annual Meeting
  • Place of Presentation: Atlanta, USA
• [Presentation] A rare genetic polymorphism in C5 confers poor response to the anti-C5 monoclonal antibody eculizumab by nine Japanese patients with PNH
  • Author(s): J Nishimura
  • Organizer: The American Society of Hematology 54th Annual Meeting
  • Place of Presentation: Atlanta, USA
• [Presentation] Evaluation of efficacy and safety of Bendamustine (B) treatment in Osaka Lymphoma Study Group (OLSG)
  • Author(s): T Kohara
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都国際会議場（京都）
• [Presentation] An anti-apoptotic molecule, Anamorsin, functions in both Fe/S cluster assembly and iron homeostasis
  • Author(s): A Tanimura
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都国際会議場（京都）
• [Presentation] PA anti-GPIIb/IIIa Abs in primary ITP recognize highly restricted regions in GPIIb with clonality
  • Author(s): K Kiyomizu
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都国際会議場（京都）
• [Presentation] Role of endothelial antigen ESAM in hematopoietic stem cells status
  • Author(s): T Sudo
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都国際会議場（京都）
• [Presentation] Detection of change in LIC by MRI in a transfusion dependent MDS patient treated with deferasirox
  • Author(s): Y Hamanaka
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都国際会議場（京都）
• [Presentation] Significance of novel HSC marker ESAM expression in cord blood
  • Author(s): T Ishibashi
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都国際会議場（京都）
• [Presentation] Efficacy and safety of L-AMB as empirical antifungal therapy in FN of hematological diseases
  • Author(s): K Hashimoto
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都国際会議場（京都）
• [Book] Advances in Hematopoietic Stem Cell Research (2012)
  • Author(s): Yokota T, Oritani K, Butz S, Ewers S, Vestweber D, Kanakura Y
  • Publisher: Intech Open Access Publisher
• [Book] 多発性骨髄腫治療マニュアル（木崎昌弘編） (2012)
  • Author(s): 水木満佐央
  • Publisher: 南江堂
• [Book] がんの浸潤・転移(高井義美編) (2011)
  • Author(s): 織谷健司, 金倉譲
  • Publisher: 南山堂
• [Book] 発作性夜間ヘモグロビン尿症.難治性貧血の診療ガイド(『難治性貧血の診療ガイド』編集委員会編) (2011)
  • Author(s): 西村純一, 金倉譲
  • Publisher: 南江堂
• [Book] 口腔外科学 (2010)
  • Author(s): 金倉譲, 他
  • Publisher: 医歯薬出版株式会社
• [Book] 疾病と治療II (2010)
  • Author(s): 織谷健司, 金倉譲, 他
  • Publisher: 南江堂
• [Book] TNM悪性腫瘍の分類 日本語版第7版 (2010)
  • Author(s): 水木満佐央, 他
  • Publisher: 金原出版
• [Book] がんの統合医療 (2010)
  • Author(s): 水木満佐央, 他
  • Publisher: メディカル・サイエンス・インターナショナル
• [Book] 看護学テキスト 疾病と治療II (2010)
  • Author(s): 柴山浩彦, 金倉譲, 他
  • Publisher: 南江堂
• [Book] 血液疾患 最新の治療 2011-2013 (2010)
  • Author(s): 西村純一, 金倉譲, 他
  • Publisher: 南江堂
• [Book] ステロイドの使い分け (2010)
  • Author(s): 西村純一, 柴山浩彦, 水木満佐央, 金倉譲, 他
  • Publisher: 羊土社
• [Book] Annual Review血液2010 (2010)
  • Author(s): 横田貴史, 織谷健司, 金倉譲, 他
  • Publisher: 中外医学社
• [Remarks] 大阪大学大学院医学系研究科 血液・腫瘍内科学ホームページ アドレス:
  • URL: http://www.hematology.pro
• [Remarks] 大阪大学大学院医学系研究科 血液・腫瘍内科学教室ホームページ
• [Remarks]