The analysis of molecular pathogenesis and mechanisms for antiphospholipid syndrome
| Project/Area Number |
22390198
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Hokkaido University |
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Principal Investigator |
KOIKE Takao 北海道大学, 大学院・医学研究科, 教授 (80146795)
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| Co-Investigator(Kenkyū-buntansha) |
ATSUMI Tatsuya 北海道大学, 大学院・医学研究科, 教授 (20301905)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | 抗リン脂質抗体症候群 / β2GPI / プロテオミクス / 抗β2-GPI抗体 / 酸化LDL / 自己抗体 / 抗リン脂質抗体 / 血栓症 / 単球 / 質量分析 / プロテオーム |
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| Research Abstract |
Oxidized LDL was detected as a major β2GPI binding plasma molecule by proteomics analysis. The presence of oxidized LDL upregulated aCL/β2GPI induced TF expression on monocytes, suggesting the involvement of oxidized LDL in the pathophysiology of thrombosis in patients with APS. LpPLA2, oxidized LDL related molecule, was higher expressed in plasma of patients with APS than those without. As performing SNP analysis for LpPLA2 related genes detected by GWAS, two risk alleles were more frequent in patients with APS compared to healthy controls, suggesting that gene anomaly in patients with APS was partially involved in high expression of oxidized LDL in patients with APS.
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Report
(4 results)
Research Products
(77 results)
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[Journal Article] Predominant prevalence of arterial thrombosis in Japanese patients with antiphospholipid2012
Author(s)
Fujieda Y, Atsumi T, Amengual O, Odani T, Otomo K, Kato M, Oku K, Kon Y, Horita T, Yasuda S, Koike T
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Journal Title
syndromeLupus
Volume: 21(14)
Issue: 14
Pages: 1506-14
DOI
Related Report
Peer Reviewed
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[Journal Article] Factor XI is a substrate for oxidoreductases: enhanced activation of reduced FXI and its role in antiphospholipid syndrome thrombosis2012
Author(s)
Giannakopoulod B, Gao L, Qi M, Wong JW, Yu DM, Vlachoyiannopoulos PG, Moutsopoulos HM, Atsumi T, Koike T, Hogg P, Qi JC, Krilis SA
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Journal Title
J Autoimmun
Volume: 39(3)
Issue: 3
Pages: 121-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Drug retention rates and relevant risk factors for drug discontinuation due to adverse events in rheumatoid arthritis patients receiving anticytokine therapy with different target molecules.2012
Author(s)
Sakai R, Tanaka M, Nanki T, Watanabe K, Yamazaki H, Koike R, Nagasawa H, Amano K, Saito K,Tanaka Y, Ito S, Sumida T,Ihata A, Ishigatsubo Y, Atsumi T, Koike T, Nakajima A, Tamura N, Fujii T, Dobashi H, Tohma S, Sugihara T, Ueki Y, Hashiramoto A, Kawakami A, Hagino N, Miyasaka N, Harigai M
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Journal Title
Ann Rheum
Volume: 71(11)
Pages: 1820-6
NAID
Related Report
Peer Reviewed
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[Journal Article] Time-dependent increased risk for serious infection from continuous use of tumor necrosis factor antagonists over three years in patients with rheumatoid arthritis2012
Author(s)
Sakai R, Komano Y, Tanaka M, Nanki T, Koike R, Nagasawa H, Amano K,Nakajima A, Atsumi T, Koike T, Ihata A, Ishigatsubo Y, Saito K,Tanaka Y, Ito S, Sumida T, Tohma S,Tamura N, Fujii T, Sugihara T, Kawakami A, Hagino N, Ueki Y, Hashiramoto A, Nagasawa K,Miyasaka N, Harigai M
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Journal Title
Arthritis Care Res
Volume: 64(8)
Issue: 11
Pages: 1125-34
DOI
Related Report
Peer Reviewed
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[Journal Article] Safety and effectiveness of switching from infliximab to etanercept in patientswith rheumatoid arthritis: results from a large Japanese postmarketing surveillance stud2012
Author(s)
Koike T, Harigai M, Inokuma S, Ishiguro N, Ryu J, Takeuchi T, Tanaka Y, Yamanaka H, Fujii K, Yoshinaga T, Freundlich B, Suzukawa M
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Journal Title
Rheumatol Int
Volume: 32(6)
Issue: 6
Pages: 1617-24
DOI
Related Report
Peer Reviewed
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[Journal Article] Safety and effectiveness responses to etanercept for rheumatoid arthritis in Japan: a sub-analysis of a post-marketing surveillance studyfocusing on the duration of rheumatoid arthritis2012
Author(s)
Koike T, Harigai M, Inokuma S, Ishiguro N, Ryu J, Takeuchi T, Tanaka Y, Yamanaka H, Fujii K, Yoshinaga T, Freundlich B, Suzukawa M
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Journal Title
Rheumatol Int
Volume: 32(6)
Issue: 6
Pages: 1511-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Golimumab in combination with methotrexate in Japanese patients with active rheumatoid arthritis: results of the GO-FORTH study2012
Author(s)
Tanaka Y, Harigai M, Takeuchi T, Yamanaka H, Ishiguro N, Yamamoto K, Miyasaka N, Koike T, Kanazawa M, Oba T, Yoshinari T, Baker D;
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Journal Title
Ann Rheum Dis
Volume: 71(6)
Issue: 6
Pages: 817-24
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Positive synovial vascularity in patients with low disease activity indicates smouldering inflammation leading to joint damage in rheumatoid arthritis: time-integrated joint inflammation estimated by synovialvascularity in each finger joint2012
Author(s)
Fukae J, Isobe M, Kitano A, Henmi M, Sakamoto F, Narita A, Ito T, Mitsuzaki A, Shimizu M, Tanimura K, Matsuhashi M, Kamishima T, Atsumi T, Koike T
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Journal Title
Rheumatology
Volume: 52(3)
Issue: 3
Pages: 523-8
DOI
Related Report
Peer Reviewed
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