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Fusion imaging for sentinel node navigation high-precision radiotherapy

Research Project

Project/Area Number 22390240
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionNational Cancer Center Japan

Principal Investigator

FUJII Hirofumi  独立行政法人国立がん研究センター, 臨床開発センター, 分野長 (80218982)

Co-Investigator(Kenkyū-buntansha) KOHNO Ryosuke  独立行政法人国立がん研究センター, 臨床開発センター, 研究員 (20392227)
TOKUUE Koichi  東京医科大学, 医学部, 教授 (00334061)
OGINO Takashi  独立行政法人国立がん研究センター, 臨床開発センター, 部長 (50415519)
Co-Investigator(Renkei-kenkyūsha) YAMAGUCHI Masayuki  独立行政法人国立がん研究センター, 臨床開発センター, ユニット長 (90450577)
UMEDA O. Izumi  独立行政法人国立がん研究センター, 臨床開発センター, ユニット長 (40160791)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywords核医学 / センチネルリンパ節 / 高精度放射線治療 / 融合画像 / SPECT
Research Abstract

This study was aimed to develop the least invasive therapeutic methods to cure early-stage cancer. We tried to visualize the metastatic status of sentinel lymph nodes that are the first nodes involved by cancer and conditions of tumor interiors such as hypoxia and the expression of integrin in vivo by using nuclear medicine images, magnetic resonance images and their fusion images. We also developed spot scanning irradiation methods by pencil beams in proton beam therapy so that the optimized therapy would be performed according to the findings of functional imaging tests.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (24 results)

All 2012 2011 2010 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (18 results)

  • [Journal Article] In Vivo SPECT Imaging with 111In-DOTA-c(RGDfK) to Detect Early Pancreatic Cancer in a Hamster Pancreatic Carcinogenesis Model.2012

    • Author(s)
      Yoshimoto M, Hayakawa T, Mutoh M, Imai T, Tsuda K, Kimura S, Umeda IO, Fujii H, Wakabayashi K
    • Journal Title

      J Nucl Med

      Volume: 53(5) Issue: 5 Pages: 765-771

    • DOI

      10.2967/jnumed.111.099630

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo visualization of heterogeneous intra- tumoral distribution of hypoxia- inducible factor-1alpha activity by the fusion of high-resolution SPECT and morphological imaging tests.2012

    • Author(s)
      Fujii H, Yamaguchi M, Inoue K, Mutou Y, Ueda M, Saji H, Kizaka-Kondoh S, Moriyama N, Umeda IO
    • Journal Title

      J Biomed Biotechnol

      Volume: 2012(262741) Pages: 1-6

    • DOI

      10.1155/2012/262741

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Optimization of coded aperture radioscintigraphy for sentinel lymph node mapping.2012

    • Author(s)
      Fujii H, Idoine JD, Gioux S, Accorsi R, Slochower DR, Lanza RC, Frangioni JV
    • Journal Title

      Mol Imaging Biol

      Volume: 14(2) Issue: 2 Pages: 173-82

    • DOI

      10.1007/s11307-011-0494-2

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of animal studies between interstitial magnetic resonance lymphography and radiocolloid SPECT/CT lymphoscintigraphy in the head and neck region.2012

    • Author(s)
      Kitamura N, Kosuda S, Araki K, Tomifuji M, Mizokami D, Shiotani A, Shinmoto H, Fujii H, Ichihara K:
    • Journal Title

      Ann Nucl Med

      Volume: 26(3) Issue: 3 Pages: 281-5

    • DOI

      10.1007/s12149-011-0565-0

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Central High Signal in Inflammatory Swollen Lymph Nodes on SPIO-enhanced Interstitial MR Lymphograms: A Mimic of Lymph Node Metastasis2012

    • Author(s)
      Suzuki D, Yamaguchi M, Furuta T, Okuyama Y, Yoshikawa K, Fujii H
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 11 Issue: 1 Pages: 61-63

    • DOI

      10.2463/mrms.11.61

    • NAID

      10030284851

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Central high signal in inflammatorily swollen lymph nodes on SPIO-enhanced interstitial MR lymphograms : a mimic of lymph node metastasis2012

    • Author(s)
      Suzuki D, et al
    • Journal Title

      Magn Reson Med Sci

      Volume: 11 Pages: 61-63

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Development of RGD-liposomes for MR imaging of pancreatic tumor.2012

    • Author(s)
      Yoshimoto M, Hayakawa T, Yamaguchi M, Kimura S, Umeda IO, Fujii H
    • Organizer
      WMIC 2012
    • Place of Presentation
      Dublin, Ireland
    • Year and Date
      2012-09-08
    • Related Report
      2012 Final Research Report
  • [Presentation] A novel PET probe for tumor hypoxia imaging with excellent renal clearance.2012

    • Author(s)
      Kimura S, Kuriyama T, Kojima YK, Umeda IO, Moriyama N, Fujii H
    • Organizer
      SNM 2012 Annual Meeting
    • Place of Presentation
      Miami Beach, FL, USA
    • Year and Date
      2012-06-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Pitfalls of SPIO-enhanced MR Lymphography in Sentinel Lymph Nodes: Pathogenesis of High Signals Mimicking Metastasis in Inflamed Lymph Nodes.2012

    • Author(s)
      Suzuki D, Yamaguchi M, Furuta T, Nakagami R, Okuyama Y, Yoshikawa K, Fujii H
    • Organizer
      ISMRM 2012 Annual Meeting
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2012-05-07
    • Related Report
      2012 Final Research Report
  • [Presentation] High-Resolution Interstitial MR Lymphography for the Diagnosis of Sentinel Lymph Nodes: Inhomogeneous Distribution of SPIO within Non-Malignant Lymph Nodes.2011

    • Author(s)
      Suzuki D, Yamaguchi M, Furuta T, Yoshikawa K, Fujii H
    • Organizer
      ISMRM 2011 Annual Meeting
    • Place of Presentation
      Montreal, Quebec, Canada
    • Year and Date
      2011-05-09
    • Related Report
      2012 Final Research Report
  • [Presentation] High-Resolution Interstitial MR Lymphography for the Diagnosis of Sentinel Lymph Nodes : Inhomogeneous Distribution of SPIO within Non-Malignant Lymph Nodes2011

    • Author(s)
      Suzuki D, et al
    • Organizer
      ISMRM 2011
    • Place of Presentation
      Montreal, Quebec, Canada
    • Year and Date
      2011-05-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] SPECT-MRI co-registration for lymph node imaging: a feasibility study using a lymphadenitis animal model.2010

    • Author(s)
      Suzuki D, Yamaguchi M, Inoue K, Umeda IO, Yoshikawa K, Fujii H
    • Organizer
      ISNS2010
    • Place of Presentation
      横浜
    • Year and Date
      2010-11-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Sentinel node concept in clinically N0 laryngeal and hypopharyngeal cancer.2010

    • Author(s)
      Araki K, Tomifuji M, Fujii H, Kosuda S, Shiotani A
    • Organizer
      ISNS2010
    • Place of Presentation
      横浜
    • Year and Date
      2010-11-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Sentinel node concept in clinically N0 laryngeal and hypopharyngeal cancer2010

    • Author(s)
      Araki K, Fujii H, et al
    • Organizer
      ISNS 2010
    • Place of Presentation
      横浜
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] SPECT-MRI co-registration for lymph node imaging : a feasibility study using a lymphadenitis animal model2010

    • Author(s)
      Suzuki D, Fujii H, et al
    • Organizer
      ISNS 2010
    • Place of Presentation
      横浜
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Interstitial MR lymphangiography in the head and neck region using superparamagnetic iron oxides and gadoxetate sodium -preliminary animal study.2010

    • Author(s)
      Kitamura N, Araki K, Kosuda S, Tomifuji M, Shiotani A, Shigematsu N, Fujii H
    • Organizer
      ISNS2010
    • Place of Presentation
      横浜
    • Year and Date
      2010-11-19
    • Related Report
      2012 Final Research Report
  • [Presentation] The detection of small LN metastases using radiocolloids.2010

    • Author(s)
      Fujii H
    • Organizer
      ISNS2010
    • Place of Presentation
      横浜
    • Year and Date
      2010-11-19
    • Related Report
      2012 Final Research Report
  • [Presentation] The detection of small LN metastases using radiocolloids2010

    • Author(s)
      Fujii H
    • Organizer
      ISNS 2010
    • Place of Presentation
      横浜(招待講演)
    • Year and Date
      2010-11-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Interstitial MR lymphangiography in the head and neck region using superparamagnetic iron oxides and gadoxetate sodium-preliminary animal study2010

    • Author(s)
      Kitamura N, Fujii H, et al
    • Organizer
      ISNS 2010
    • Place of Presentation
      横浜
    • Year and Date
      2010-11-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Precise Co-registration of SPECT and MRI for Small Animal Imaging using a Common Animal Bed with External References:Visualization of Macrophage Distribution within Inflammatory Lymph Nodes.2010

    • Author(s)
      Yamaguchi M, Suzuki D, Shimizu R, Nakagami R, Tsuda K, Umeda IO, Okuyama Y, Yoshikawa K, Fujii H
    • Organizer
      ISMRM-ESMRMB Joint Annual Meeting 2010
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2010-05-06
    • Related Report
      2012 Final Research Report
  • [Presentation] Precise Co-registration of SPECT and MEI for Small Animal Imaging using a Common Animal Bed with External References : Visualization of Macrophage Distribution within Inflammatory Lymph Nodes2010

    • Author(s)
      Yamaguchi M, Fujii H, et al
    • Organizer
      ISMRM-ESMRMB Joint Annual Meeting 2010
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2010-05-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Pitfalls of SPIO-enhanced MR Lymphography in Sentinel Lymph Nodes: Pathogenesis of High Signals Mimicking Metastasis in Inflamed Lymph Nodes

    • Author(s)
      Suzuki D
    • Organizer
      ISMRM 2012 Annual Meeting
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2012 Annual Research Report
  • [Presentation] A novel PET probe for tumor hypoxia imaging with excellent renal clearance

    • Author(s)
      Kimura S
    • Organizer
      SNM 2012
    • Place of Presentation
      Miami Beach, FL, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Development of RGD-liposomes for MR imaging of pancreatic tumor

    • Author(s)
      Yoshimoto M
    • Organizer
      WMIC 2012
    • Place of Presentation
      Dublin, Ireland
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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