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Studies for the functional difference of STX1A and STX1B in vivo

Research Project

Project/Area Number 22500338
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionKyorin University

Principal Investigator

FUJIWARA Tomonori  杏林大学, 医学部, 准教授 (90255399)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsシナプス伝達 / シンタキシン / 痙攣 / 遺伝子欠損マウス / 遺伝子改変マウス / 行動異常 / 開口放出 / syntaxin / 遺伝子組み換えマウス / シナプス / SNARE蛋白質
Research Abstract

In neurons, two types of syntaxin (STX) isoforms, STX1A and STX1B,were expressed. It was believed that STX1A and STX1B have same function. However, we demonstrated that these proteins exhibited distinctive function in vivo. We showed the difference of the interaction with one of the STX binding proteins, Munc18, which might cause for the functional differences.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (40 results)

All 2013 2012 2011 2010

All Journal Article (15 results) (of which Peer Reviewed: 7 results) Presentation (25 results)

  • [Journal Article] Oligomerised lychee fruit-derived polyphenol attenuates cognitive impairment in senescence-accelerated mice and endoplasmic reticulum stress in neuronal cells2013

    • Author(s)
      Sakurai T, Kitadate K, Nishioka H, Fujii H, Ogasawara J, Kizaki T, Sato S, Fujiwara T, Akagawa K, Izawa T, Ohno H
    • Journal Title

      Br J Nutr

      Volume: 28 Pages: 1-10

    • Related Report
      2012 Final Research Report
  • [Journal Article] Oligomerised lychee fruit-derived polyphenol attenuates cognitive impairment in senescence-accelerated mice and endoplasmic reticulum stress in neuronal cells.2013

    • Author(s)
      Sakurai T
    • Journal Title

      Br J Nutr.

      Volume: 1 Pages: 1-10

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exercise training and the promotion of neurogenesis and neurite outgrowth in the hippocampus2012

    • Author(s)
      Sakurai T, Ogasawara J, Kizaki T, Ishibashi Y, Fujiwara T, Akagawa K, Izawa T, Radak Z, Ohno H
    • Journal Title

      J Phys Fitness Sports Med

      Volume: 1(2) Pages: 333-337

    • NAID

      10031158961

    • Related Report
      2012 Final Research Report
  • [Journal Article] Impairment of Catecholamine Systems during Induction of Long-Term Potentiation at Hippocampal CA1 Synapses in HPC-1/Syntaxin 1A Knock-out MiceJ2012

    • Author(s)
      T Mishima T Fujiwara T Kofuji and K Akagawa
    • Journal Title

      Neurosci

      Volume: 32 Pages: 381-389

    • Related Report
      2012 Final Research Report
  • [Journal Article] Impairment of Catecholamine Systems during Induction of Long-Term Potentiation at Hippocampal CA1 Synapses in HPC-1/Syntaxin 1A Knock-out Mice2012

    • Author(s)
      Tatsuya Mishima
    • Journal Title

      J. Neurosci

      Volume: 32 Pages: 381-389

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exercise training and the promotion of neurogenesis and neurite outgrowth in the hippocampus2012

    • Author(s)
      Sakurai T
    • Journal Title

      J Phys Fitness Sports Med

      Volume: 1 Pages: 333-337

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of leucine zipper transcription factor-like protein 1 (Lztfl1)in the attenuation of cognitive impairment by exercise training2011

    • Author(s)
      T Sakurai, J Ogasawara, T Kizaki, Y Ishibashi, T Fujiwara, K Akagawa, T Izawa, S Oh-ishi, S Haga, H Ohno
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 416 Pages: 125-129

    • Related Report
      2012 Final Research Report
  • [Journal Article] Dysfunction of the Hypothalamic-Pituitary-Adrenal axis in STX1A KO mice2011

    • Author(s)
      Fujiwara T, Kofuji T, Akagawa K
    • Journal Title

      J Neuroendocrinol

      Volume: 23 Pages: 1222-1230

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] Unusual retinal layer organization in HPC-1/syntaxin 1A knockout mice2011

    • Author(s)
      Kaneko Y, Suge R, Fujiwara T, Akagawa K, Watanabe SI
    • Journal Title

      J Mol Histol

      Volume: 42 Pages: 483-9

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] LOSS OF GRANUPHILIN AND OF SYNTAXIN-1A CAUSE DIFFERENTIAL EFFECTS ON INSULIN GRANULE DOCKING AND FUSIONHPC-1/syntaxin 1A gene knockout mice show abnormal behavior possibly related to a disruption in 5-HTergic systems2011

    • Author(s)
      H Wang, R Ishizaki, E Kobayashi, T Fujiwara, K Akagawa and T Izumi
    • Journal Title

      J. Biol. Chem

      Volume: 286 Pages: 32244-50

    • Related Report
      2012 Final Research Report
  • [Journal Article] Impairment of Catecholamine Systems during Induction of Long-Term Potentiation at Hippocampal CA1 Synapses in HPC-1/Syntaxin 1A Knock-out Mice2011

    • Author(s)
      T Mishima, T Fujiwara, T Kofuji, K Akagawa
    • Journal Title

      J.Neurosci

      Volume: 32 Pages: 381-389

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of leucine zipper transcription factor-like protein 1 (Lztfl1) in the attenuation of cognitive impairment by exercise training2011

    • Author(s)
      T Sakurai, J Ogasawara, T Kizaki, Y Ishibashi, T Fujiwara, K Akagawa, T Izawa, S Oh-ishi, S Haga, H Ohno
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 416 Pages: 125-129

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LOSS OF GRANUPHILIN AND OF SYNTAXIN-1A CAUSE DIFFERENTIAL EFFECTS ON INSULIN GRANULE DOCKING AND FUSION2011

    • Author(s)
      H Wang, R Ishizaki, E Kobayashi, T Fujiwara, K Akagawa, T Izumi
    • Journal Title

      J.Biol.Chem.

      Volume: 286 Pages: 32244-50

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] J. Neurosci2010

    • Author(s)
      T Fujiwara, M Snada, T Kofuji, T Yoshikawa and K Akagawa
    • Journal Title

      Eur

      Volume: 32 Pages: 99-107

    • Related Report
      2012 Final Research Report
  • [Journal Article] HPC-1/syntaxin 1A gene knockout mice show abnormal behavior possibly related to a disruption in 5-HTergic systems2010

    • Author(s)
      Fujiwara, et al
    • Journal Title

      Eur.J.Neurosci.

      Volume: 32 Pages: 99-107

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] STX1A and STX1B knockout mice exhibited autistic disorder and schizophrenia like neuropsychological abnormalities, respectively.2013

    • Author(s)
      Tomonori Fujiwara
    • Organizer
      日本神経科学会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Glial cells from STX1B-KO mice were less effective on neuronal survival than WT2012

    • Author(s)
      T Kofuji, T Fujiwara, T Mishima and K Akagawa
    • Organizer
      日本神経化学会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] DA release in STX1B heterozygous mutant mice was increased in vivo, but not in vitro2012

    • Author(s)
      T Fujiwara, T Kofuji, T Mishima and K Akagawa
    • Organizer
      日本神経科学会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] Functional differences between syntaxin1A and syntaxin1B in fast synaptic transmission2012

    • Author(s)
      T Mishima, T Fujiwara, M Sanada T Kofuji, and K Akagawa
    • Organizer
      日本神経科学会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] Diminishment of the cortical signal propagation in HPC-1 / syntaxin 1A knockout mice2012

    • Author(s)
      M Osanai, A Matsumura, T Fujiwara, I Mori, K Akagawa, T Yagi
    • Organizer
      日本生理学会
    • Place of Presentation
      松本
    • Related Report
      2012 Final Research Report
  • [Presentation] Functional differences between syntaxin1A and syntaxin1B in fast synaptic transmission.2012

    • Author(s)
      Tatsuya Mishima
    • Organizer
      日本神経科学会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] DA release in STX1B heterozygous mutant mice was increased in vivo, but not in vitro.2012

    • Author(s)
      Tomonori Fujiwara
    • Organizer
      日本神経科学会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] The genetic analysis of HPC-1/STX1A and STX1B revealed the distinctive functions in vivo2011

    • Author(s)
      T Fujiwara, T Kofuji, T Mishima and K Akagawa
    • Organizer
      日本生理学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Diminishment of the cortical signal propagation in HPC-1 / syntaxin 1A knockout mice2011

    • Author(s)
      M Osanai, A Matsumura, T Fujiwara, I Mori, K Akagawa, T Yagi
    • Organizer
      日本神経科学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] A study on the neuronal phenotype of syntaxin1B knockout mice: implication of differential role of syntaxin1A and syntaxin1B in synaptic transmission2011

    • Author(s)
      T Mishima, T Fujiwara, M Sanada, T Kofuji, K Akagawa
    • Organizer
      日本神経科学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Distinct roles of HPC-1/STX1A and STX1B in neuronal survival2011

    • Author(s)
      T Kofuji, T Fujiwara, M Sanada, T Mishima, K Akagawa
    • Organizer
      日本神経科学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Analyses of insulin-granule docking and fusion in Granuphilin- and/or Syntaxin-1aknockout mice2011

    • Author(s)
      R Ishizaki, H Wang, T Fujiwara, K Akagawa, and T Izumi
    • Organizer
      日本生化学会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] oligonolの老化促進モデルマウスの認知機能障害に対する予防効果と海馬におけるターゲト分子の同定2011

    • Author(s)
      櫻井拓也、北舘健太郎、西岡浩、若命浩二、藤井創、小笠原準悦、木崎節子、石橋義永、藤原智徳、赤川公朗、中野法彦、井澤鉄也、大野秀樹
    • Organizer
      統合医療機能性食品国際会議
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] oligonolは神経細胞において小胞体ストレスを減弱させる2011

    • Author(s)
      櫻井拓也、北舘健太郎、西岡浩、若命浩二、藤井創、小笠原準悦、石橋義永、木崎節子、藤原智徳、赤川公朗、炭谷由計、石田均、芳賀脩光、大野秀樹
    • Organizer
      日本予防医学学会
    • Place of Presentation
      東京 東京
    • Related Report
      2012 Final Research Report
  • [Presentation] The genetic analysis of HPC-1/STX1A and STX1B revealed the distinctive functions in vivo2011

    • Author(s)
      T Fujiwara, T Kofuji, T Mishima, K Akagawa
    • Organizer
      日本生理学会
    • Place of Presentation
      横浜(誌上開催)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Diminishment of the cortical signal propagation in HPC-1/syntaxin 1A knockout mice2011

    • Author(s)
      M Osanai, A Matsumura, T Fujiwara, I Mori, K Akagawa, T Yagi
    • Organizer
      日本神経科学会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] A study on the neuronal phenotype of swtaxin1B knockout mice : implication of differential role of syntaxin1A and syntaxin1B in synaptic transmission2011

    • Author(s)
      T Mishima, T Fujiwara, M Sanada, T Kofuji, K Akagawa
    • Organizer
      日本神経科学会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Analyses of insulin-granule docking and fusion in Granuphilin- and/or Syntaxin-1a-knockout mice2011

    • Author(s)
      R Ishizaki, H Wang, T Fujiwara, K Akagawa, T Izumi
    • Organizer
      日本生化学会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] oligonolは神経細胞において小胞体ストレスを減弱させる2011

    • Author(s)
      櫻井拓也、北舘健太郎、西岡浩、若命浩二、藤井創、小笠原準悦、石橋義永、木崎節子、藤原智徳、赤川公郎、炭谷由計、石田均、芳賀脩光、大野秀樹
    • Organizer
      日本予防医学学会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] 老化促進モデルマウスの認知機能障害に対してOligonolは運動と同様に予防効果を持つ2010

    • Author(s)
      櫻井拓也, 他
    • Organizer
      統合医療機能性食品国際会議
    • Place of Presentation
      札幌
    • Year and Date
      2010-07-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 老化促進モデルマウスの認知機能障害に対してoligonolは運動と同様に予防効果を持つ2010

    • Author(s)
      櫻井拓也、北舘健太郎、西岡浩、若命浩二、藤井創、小笠原準悦、木崎節子、石橋義永、藤原智徳、赤川公朗、中野法彦、斉藤大蔵、根本浩一郎、芳賀脩光、大野秀樹
    • Organizer
      統合医療機能性食品国際会議
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] A study on the phenotype of syntaxin1B knockout mice2010

    • Author(s)
      T Fujiwara, M Sanada, T Kofuji, T Mishima and K Akagawa
    • Organizer
      日本神経科学会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] Impaired induction of long-term potentiation in HPC-1/syntaxin 1A knockout mice may be due to altered catecholaminergic system2010

    • Author(s)
      T Mishima, T Fujiwara, T Kofuji, K Akagawa
    • Organizer
      日本神経科学会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] HPC-1/STX1A and STX1B might have distinct roles in neuronal function2010

    • Author(s)
      T Fujiwara, T Kofuji, T Mishima, MKanai-Azuma and K Akagawa
    • Organizer
      日本生理学会
    • Place of Presentation
      盛岡
    • Related Report
      2012 Final Research Report
  • [Presentation] HPC-1/STX1A and STX1B might have distinct roles in neuronal function.2010

    • Author(s)
      Fujiwara, et al
    • Organizer
      日本生理学会
    • Place of Presentation
      盛岡
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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