Analysis of mechanisms of heartbeat initiation in embryonic stage
| Project/Area Number |
22500365
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Takeshi 札幌医科大学, 医学部, 講師 (80363688)
MADEA Sachiko 札幌医科大学, 医学部, 助教 (80343391)
ICHISE Nobutoshi 札幌医科大学, 医学部, 助教 (60448610)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 心臓 / 自動能 / 発生分化 / カルシウムチャネル / 興奮収縮連関 / タンパク定量 / パッチクランプ / 心臓原基 / 発生・分化 / 活動電位 / 蛍光色素 / 分子生物学 / 生理学 |
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| Research Abstract |
In early embryonic stage, rat heart primordium begins the heatbeating. In cardiomyocytes from the early primordium, calcium current was observed. The calcium current was activated in pacemaker potential, and may be related to automaticity of heart. During this embryonic stage, gene expression and construction of protein molecule for the calcium channel (Cav1.3) were observed. The Cav 1.3 channels may be determinant for initiation of heart beat.
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Report
(4 results)
Research Products
(19 results)
