Alteration of fucosylation and biomarker development in lung cancer

• Project/Area Number: 22501029
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Tumor diagnosis
• Research Institution: Hokkaido University
• Principal Investigator: AKITA Hirotoshi 北海道大学, 大学院・医学研究科, 教授 (70222528)
• Co-Investigator(Renkei-kenkyūsha): KINOSHITA Ichiro 北海道大学, 大学院・医学研究科, 准教授 (40343008)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: バイオマーカー / 肺癌 / 糖鎖 / 糖転移酵素〓1-6fucosyltransferase / 非小細胞肺癌 / 糖転移酵素 / alfa 1-6フコース転移酵素 / alfa1,6-フコース転移酵素 / α1,6-フコース転移酵素

Research Abstract

High 〓1-6 fucosyltransferase (〓1-6 FucT) expression is more frequently found in adenocarcinomas than squamous cell carcinomas, and is correlated with advanced pN status in adenocarcinomas. High 〓1,6-FT expression is associated with an unfavorable clinical outcome in potentially curatively resected and pStage I adenocarcinomas. These findings suggest that 〓1,6-FT and its core-fucosylated products could be promisingbiomarkers and therapeutic targets for NSCLCs, especially for adenocarcinomas.

Research Products

• [Presentation] Prognostic significance of 〓1,6 fucosyltransferase (〓1,6 FT) in non-small cell lung cancers (NSCLCs). (2013)
  • Author(s): Honma R, Dosaka-Akita H, Kinoshita I
  • Organizer: 2013 Annual Meeting of American Society of Clinical Oncology (ASCO).
  • Place of Presentation: McCormick Place (シカゴ、米国).
  • Year and Date: 2013-06-01
• [Presentation] Decreased expression of GMDand GDP-fucose transporter is associated with squamous histology in NSCLCs. (2011)
  • Author(s): Honma R, Dosaka-Akita H, Kinoshita I
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場.
  • Year and Date: 2011-10-03
• [Presentation] GDP-mannose-4,6-dehydratase (GMD) and GDP-fucose transporter in non-small cell lung cancers (NSCLCs) : their decreased expression insquamous cell carcinomas by immunohistochemistry. (2011)
  • Author(s): Honma R, Dosaka-Akita H, Kinoshita I
  • Organizer: 14th World Conference on Lung Cancer of International Association for the Studyof Lung Cancer.
  • Place of Presentation: Amsterdam RAI(アムステルダム、オラ ンダ)
  • Year and Date: 2011-07-05
• [Presentation] Decreased expression of GMD in non-small cell lung cancers (NSCLCs). (2011)
  • Author(s): Honma R, Dosaka-Akita H, Kinoshita I
  • Organizer: 102nd Annual Meeting of AmericanAssociation of Cancer Research (AACR).
  • Place of Presentation: Orange CountyConvention Center(オーランド、米国)
  • Year and Date: 2011-04-05
• [Presentation] Decreased expression of GMD in non-small cell lung cancers (NSCLCs) (2011)
  • Author(s): Honma R, et al.
  • Organizer: 102nd Annual Meeting of AACR
  • Place of Presentation: Orange County Covention Center、米国
  • Year and Date: 2011-04-05
• [Presentation] Prognostic significance of alfa 1,6 fucosyltransferase in non-small cell lung cancers (NSCLCs)
  • Author(s): Hirotoshi Dosaka-Akita
  • Organizer: 米国臨床腫瘍学会2013
  • Place of Presentation: マコーミック・コンベンションセンター（シカゴ、イリノイ州、米国）