Development of cancer diagnostic system using anti-diacetylpolyamine RNA aptamer
| Project/Area Number |
22501036
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor diagnosis
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
OGURO Akihiro 東京慈恵会医科大学, 医学部, 講師 (00292508)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 機能性RNA / アプタマー / がん診断 / ジアセチルスペルミン / ポリアミン |
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| Research Abstract |
Polyamines are ubiquitous biogenic amines and essential for proliferation. Cancer cells generally contain elevated levels of polyamines. Anti-polyamine aptamers would discriminate each polyamine and be potential diagnostic and prognostic tools for malignant disorders. In this study, I isolated RNA aptamer against polyamine and analyzed its binding activity, specificity and polyamine-binding property. Furthermore, I indicated the sensing system with this aptamer was useful to detect polyamine in solution.
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Report
(4 results)
Research Products
(22 results)
