| Project/Area Number |
22590024
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | Kyoto Pharmaceutical University |
|---|
Principal Investigator |
OZEKI Minoru 京都薬科大学, 薬学部, 助教 (40465597)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Masayuki 京都薬科大学, 薬学部, 教授 (20239982)
HOSOI Shinzo 京都薬科大学, 薬学部, 准教授 (60209236)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 不斉合成 / キラルアミン / Michael 付加 / tandem 反応 / 多連続不斉炭素 / tandem反応 / グリーンケミストリー / Michael付加反応 / α-ヒドロキシ-β-アミノ酸 / 不斉プロトン化 / tandem Michael-aldol反応 / double Michael付加反応 / tandem double Michael-aldol反応 |
|---|
| Research Abstract |
We developed the novel tandem reaction to enable the construction of the multi contiguous chiral centers taking advantage of asymmetric Michael addition of chiral amine. As a result, 2 to 5 contiguous chiral centers were finely constructed in one pot utilizing five types of Michael addition, i.e., tandem Michael-alkylation, tandem Michael-oxidation, tandem Micheal-aldol, double Michael addition and double Michael-aldol reaction, which were triggered by a nucleophilic attack of chiral amine.
|
