Investigation on the production and/or metabolism of D-kynurenine in schizophrenia
| Project/Area Number |
22590147
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Toho University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHIGUCHI Yoshikazu 東邦大学, 薬学部, 助教 (60459823)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 統合失調症 / D-キヌレニン / キヌレン酸 / D-アミノ酸酸化酵素 / D-トリプトファン / 蛍光検出 / 代謝 / ケタミン / D-アミノ酸酸化酵素（DAAO） / マイクロダイアリシス / D-アミノ酸酸化酵素(DAAO) / 脳神経疾患 / 分析科学 |
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| Research Abstract |
D-Kynurenine (D-KYN) was metabolized to kynurenic acid (KYNA), which is an antagonist of NMDA receptor in brain, and D-amino acid oxidase (DAAO), one of the susceptible genes of schizophrenia, was found to be responsible for the production of KYNA from D-KYN. The metabolism of D-KYN to KYNA has been enhanced in the brain of animal model of schizophrenia, and the D-KYN was produced from D-tryptophan. In addition, a screening method for the inhibitor of DAAO was newly developed
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Report
(4 results)
Research Products
(103 results)
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[Presentation] 新規薬物依存抑制因子shatiは微小管の安定化に関与する2011
Author(s)
鳥海和也, 近藤水生, 本荘龍輝, 武藤瑛里子, 古関竹直, 永井拓, 宋梓瑜, 宮本嘉明, 新田淳美, 山田清文, 福島健, 鍋島俊隆
Organizer
平成23年度アルコール・薬物依存関連学会合同学術集会
Place of Presentation
愛知県名古屋市、愛知県産業労働センター
Related Report
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