Investigation about the effect of Adrenomedullin on pulmonary function and development of emphysema of old mice

• Project/Area Number: 22590835
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: The University of Tokyo
• Principal Investigator: YAMAMOTO Hiroshi 東京大学, 医学部附属病院, 講師 (10361487)
• Co-Investigator(Kenkyū-buntansha): NAGASE Takahide 東京大学, 医学部附属病院, 教授 (40208004) ; YAMAGUCHI Yasuhiro 東京大学, 医学部附属病院, 講師 (60376473) ; 新藤 隆行 信州大学, 医学(系)研究科(研究院), 教授 (90345215)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 閉塞性肺疾患 / アドレノメデュリン

Research Abstract

We investigated pulmonary function and histological changes of old or young AM-KO mice correspondent with its littermate control. RV and RV/TLC of old mice were significantly increased compared with that of young mice. Mean linear intercept (Lm) of old mice was significantly increased than that of young mice. Mean alveolar area and destructive index (DI) were not significantly increased. AM gene modification did not have any effect on these indexes.