Role of interstitial sodium accumulation on inflammatory cytokines and lymphcapillary reconstruction in salt-sensitive hypertension.
| Project/Area Number |
22590907
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KURABAYASHI Masahiko (00215047)
SAITO Yuichiro (30344922)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 高血圧学 / 圧ナトリウム利尿曲線 / 循環器・高血圧 / 内科 / 発現制御 |
|---|
| Research Abstract |
In vascular endothelial cells, the active form of human heat shock factor-1 (HSF1) raised the levels of endothelial nitric oxide synthase (relaxation factor) and thrombomodulin (anticoagulation factor). The gene expression of oxidative stress was elevated in renal medulla in salt-sensitive hypertensive rats. The results suggestthat renal lymphcapillary reconstruction should reduce renal medullary blood flow, induce the rightward shift of the pressure-natriuresis curve and lead to the development of salt-sensitive hypertension.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] on behalf of the RAISE study group investigators2012
Author(s)
Kobayashi T, Saji T, Otani T, Takeuchi K, Nakamura T, Arakawa H, Kato T, Hara T, Hamaoka K, Ogawa S, Miura M, Nomura Y, Fuse S, Ichida F, Seki M, Fukazawa R, Ogawa C, Furuno K, Tokunaga H, Takatsuki S, Hara S, Morikawa A
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Journal Title
Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial. Lancet
Volume: 379
Pages: 1613-1620
Related Report
Peer Reviewed
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[Presentation] Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasakisisease: a prospective, randomised, open, blinded-endpoint trial.2012
Author(s)
Kobayashi T, Saji T, Takeuchi K, Nakamura T, Arakawa H, Ogawa S, Miura M, Nomura Y, Ichida F, Seki M, Morikawa A.
Organizer
Circ J 76(Suppl. I):I-550, 2012 The 76th annual scientific meeting of the Japanese Circulation Society
Related Report
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[Presentation] The RAISE Study Investigators. Abstract 9271: Significance of primary therapy with intravenous immunoglobulin plus predonisolone for severe Kawasaki disease: result from Japanese multicenter randomized clinical trial2011
Author(s)
Kobayashi T, Saji T, Otani T, Takeuchi K, Nakamura T, Arakawa H, Kato T, Hara T, Hamaoka K, Ogawa S, Miura M, Nomura Y, Fuse S, Ichida F, Seki M, Morikawa A
Organizer
Circulation124: A17014, 2011.
Place of Presentation
Scientific Sessions2011, American Heart Association
Related Report
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