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The analysis of pathogenesis of idiopathic chronic urticaria and its development of diagnotic methods.

Research Project

Project/Area Number 22591231
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionNihon University

Principal Investigator

TERUI Tadashi  日本大学, 医学部, 教授 (30172109)

Co-Investigator(Kenkyū-buntansha) OKAYAMA Yoshimichi  日本大学, 医学部, 准教授 (80292605)
INADOMI Toru  日本大学, 医学部, 准教授 (10451345)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords皮膚免疫 / 炎症学 / 皮膚 / アレルギー / 蕁麻疹 / 病態 / 新規診断法
Research Abstract

Though the idiopathic chronic urticaria is one of the unidentifiable diseases, many people have this disease. We measured the anti-FceRI antibody, which is one of the antibodies of auto immune urticaria. There are no differences between the patients and controls in quantity of antibody. Further investigations about this antibody are undergone. Many factors are involved in pathogenesis of urticaria, we showed that substance P, one of the neuropeptide, affected the mast cells which played the major role in urticaria.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (24 results)

All 2012 2011 2010 Other

All Journal Article (16 results) (of which Peer Reviewed: 10 results) Presentation (8 results)

  • [Journal Article] Theinteraction between Lyn and FcεRIβis indispensable for FcεRI-mediated human mast cell activation.2012

    • Author(s)
      Okayama Y,
    • Journal Title

      Allergy.

      Volume: 67(10) Pages: 1241-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Omalizumab inhibits acceleration of FcεRI-mediated responsiveness of immature human mast cells by immunoglobulin E.2012

    • Author(s)
      Okayama Y
    • Journal Title

      Ann Allergy Asthma Immunol.

      Volume: 108(3) Pages: 188-94

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heregulin activation of ErbB2/ErbB3 signaling potentiates the integrity of airway epithelial barrier.2012

    • Author(s)
      Okayama Y
    • Journal Title

      Exp Cell Res.

      Volume: 317(13) Pages: 1947-53

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] アナフィラキシーショックの病態生理2012

    • Author(s)
      岡山 吉道
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 58 Pages: 571-574

    • Related Report
      2012 Annual Research Report
  • [Journal Article] The interaction between Lyn and FcεRIβ is indispensable for FcεRI-mediated human mast cell activation.2012

    • Author(s)
      岡山 吉道
    • Journal Title

      Allergy

      Volume: 67 Pages: 1241-1249

    • NAID

      10031146235

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ヒトマスト細胞の多様性(総説)2012

    • Author(s)
      岡山 吉道
    • Journal Title

      アレルギー

      Volume: 61 Pages: 792-797

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 【マスト細胞の活性化をめぐって】 ヒトマスト細胞のサブセットとその性状2012

    • Author(s)
      岡山 吉道
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 57 Pages: 597-600

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Omalizumab inhibits acceleration of FcεRI-mediated responsiveness of immature human mast cells by immunoglobulin E2012

    • Author(s)
      岡山吉道
    • Journal Title

      Ann Allergy Asthma Immunol

      Volume: 108巻3号 Pages: 188-194

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional inhibition of hypertrophic scars by a gene silencer, pyrrole-imidazole polyamide, targeting the TGF-β1 promoter.2011

    • Author(s)
      Washio H, Terui T. (他5名)
    • Journal Title

      J Invest Dermatol1

      Volume: 31(10) Pages: 1987-95

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gold activates mast cells via calcium influx through multiple H2O2-sensitive pathways including L-type calcium channels.2011

    • Author(s)
      Hayama K, Terui T.
    • Journal Title

      Free Radic Biol Med.

      Volume: 50(10) Pages: 1417-28

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] PAFレセプターによるマスト細胞の活性化マスト細胞のFCεレセプターIβ鎖ペプチドによるIgE依存性の脱顆粒抑制2011

    • Author(s)
      岡山吉道
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 56巻6号 Pages: 648-653

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 気管支喘息の病態、診断と治療;最近の進歩】病態マスト細胞2011

    • Author(s)
      岡山吉道
    • Journal Title

      救急医学

      Volume: 35巻5号 Pages: 533-535

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Identification and analysis of an early diagnostic marker for malignant melanoma: ZAR1 intra-genic differential methylation.2010

    • Author(s)
      Shinojima Y, Terui T.
    • Journal Title

      J Dermatol Sci.

      Volume: 59(2) Pages: 98-106

    • NAID

      10027401820

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prolonged culture of mast cells withhigh-glucose medium enhances the Fc epsilon RI-mediated degranulation response and leukotriene C4 production.2010

    • Author(s)
      Kitahata Y, Terui T.
    • Journal Title

      Int Arch Allergy Immunol.

      Volume: 152 Suppl1 Pages: 22-31

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Okayama YActivation of human mast cells through the platelet activating factor receptor.2010

    • Author(s)
      Kajiwara N
    • Journal Title

      J Allergy Clin Immunol

      Volume: 125(5) Pages: 1137-1145

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] PAFレセプターによるマスト細胞の活性化2010

    • Author(s)
      岡山吉道, 権寧博, 浅野正岳, 秋久俊博, 照井正, 羅智靖
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 54 Pages: 149-154

    • Related Report
      2010 Annual Research Report
  • [Presentation] 慢性蕁麻疹患者における自己反応性IgEの検討2012

    • Author(s)
      畠田優子、照井正、岡山吉道
    • Organizer
      第62回日本アレルギー学会秋季学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2012-12-15
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト皮膚マスト細胞に発現しているMrgX2受容体の慢性蕁麻疹の病態への関与2012

    • Author(s)
      藤澤大輔、照井正、岡山吉道
    • Organizer
      第62回日本アレルギー学会秋季学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2012-12-01
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒトマスト細胞の多様性2011

    • Author(s)
      岡山吉道
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-11-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒトマスト細胞の多様性2011

    • Author(s)
      岡山吉道
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 金属イオンによるマスト細胞の活性化2011

    • Author(s)
      葉山惟大、照井正
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 慢性蕁麻疹患者における自己反応性IgEの検討

    • Author(s)
      畠田優子
    • Organizer
      アレルギー・好酸球研究会2012
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 慢性蕁麻疹患者における血中自己反応性IgEの検討

    • Author(s)
      畠田優子
    • Organizer
      第62回日本アレルギー学会秋季学術大会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒト皮膚マスト細胞に発現しているMrgX2受容体の慢性蕁麻疹の病態への関与

    • Author(s)
      藤澤大輔
    • Organizer
      第62回日本アレルギー学会秋季学術大会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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