Risk-based diagnostic approach in cardiac imaging

• Project/Area Number: 22591320
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kanazawa University
• Principal Investigator: NAKAJIMA Kenichi 金沢大学, 医学系, 准教授 (00167545)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 虚血性心疾患 / 心血管イメージング / 心臓核医学 / 疾患リスク / 多施設研究

Research Abstract

While multiple modalities are available in cardiac imaging, information from imaging and clinical backgrounds were integrated in this study to estimate the patients risk for serious cardiac events. Databases of myocardial perfusion single-photon emission computed tomography were standardized, and parameters derived from fatty acid and sympathetic imaging were standardized. The specific software for standardized measurements was also created. Factors related to the high-risk and low-risk patients were determined by multicenter studies, and the risk-calculation software and risk charts were published. Risk-based diagnostic approach provided essential information for utilizing multiple diagnostic modalities.

Research Products

• [Journal Article] Standardization of meta-iodobenzylguanidine heart-to-mediastinum ratio using a calibration phantom: Effects of correction on normal databases and a multi-center study (2012)
  • Author(s): Nakajima K, Okuda K, Matsuo S, Yoshita M, Taki J, Yamada M, Kinuya S
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 39 Pages: 113-119
  • Peer Reviewed
• [Journal Article] Cardiac event risk in Japanese subjects estimated using gated myocardial perfusion imaging, in conjunction with diabetes mellitus and chronic kidney disease (2012)
  • Author(s): Nakajima K, Matsuo S, Okuyama C, Hatta M, Tsukamoto K, Nishimura S, Yamashina A, Nishimura T
  • Journal Title: Circ J Volume: 76 Pages: 168-175
  • NAID: 10030034579
  • Peer Reviewed
• [Journal Article] Cardiovascular events in Japan: Lessons from the J-ACCESS multicenter prognostic study using myocardial perfusion imaging (2012)
  • Author(s): Nakajima K, Nishimura T
  • Journal Title: Circ J Volume: 76 Pages: 1313-1321
  • NAID: 10030315788
  • Peer Reviewed
• [Journal Article] Standardization of metaiodobenzylguanidine heart-to-mediastinum ratio using a calibration phantom : Effects of correction on normal databases and a multi-center study (2012)
  • Author(s): Nakajima K, Okuda K, et al
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 39 Issue: 1 Pages: 113-9
  • DOI: 10.1007/s00259-011-1963-1
  • Peer Reviewed
• [Journal Article] 心臓核医学から見た日本人におけるSPECTと心機能の標準データベース (2012)
  • Author(s): 中嶋憲一
  • Journal Title: 日本心臓病学会誌 Volume: 7 Pages: 1-7
  • NAID: 10030334546
  • Peer Reviewed
• [Journal Article] Wakabayashi H, Taki J, Kinuya S. Cause of apical thinning on attenuation-corrected myocardial perfusion SPECT (2011)
  • Author(s): Okuda K, Nakajima K, Matsuo S
  • Journal Title: Nucl Med Commun Volume: 32 Pages: 1033-1039
  • Peer Reviewed
• [Journal Article] Quantification of myocardial perfusion SPECT using freeware package (cardioBull) (2011)
  • Author(s): Okuda K, Nakajima K, Hosoya T, Ishikawa T, Matsuo S, Kawano M, Taki J, Kinuya S
  • Journal Title: Ann Nucl Med Volume: 25 Pages: 571-579
  • NAID: 10030232773
  • Peer Reviewed
• [Journal Article] Semi-automated algorithm for calculating heart-to-mediastinum ratio in cardiac Iodine-123 MIBG imaging (2011)
  • Author(s): kuda K, Nakajima K, Hosoya T, Ishikawa T, Konishi T, Matsubara K, Matsuo S, Kinuya S.
  • Journal Title: J Nucl Cardiol Volume: 18 Pages: 82-89
  • NAID: 120002772015
  • Peer Reviewed
• [Journal Article] Visual versus quantitative assessment: a new viewpoint for cardiac function using motion tracking method (2011)
  • Author(s): Nakajima K
  • Journal Title: Circ J Volume: 75 Pages: 57-58
• [Journal Article] Cause of apical thinning on attenuation-corrected myocardial perfusion SPECT (2011)
  • Author(s): Okuda K, Nakajima K, et al
  • Journal Title: Nucl Med Commun Volume: 32 Issue: 11 Pages: 1033-9
  • DOI: 10.1097/mnm.0b013e32834b69e1
  • NAID: 120003518404
  • Peer Reviewed
• [Journal Article] Estimation of Cardiac Event Risk by Gated Myocardial Perfusion Imaging and Quantitative Scoring Methods Based on a Multi-Center J-ACCESS Database (2011)
  • Author(s): Nakajima K, Matsuo S, et al
  • Journal Title: Circulation Journal Volume: 75 Issue: 10 Pages: 2417-2423
  • DOI: 10.1253/circj.CJ-11-0371
  • NAID: 10029459560
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Quantification of myocardial perfusion SPECT using freeware package (cardioBull) (2011)
  • Author(s): Okuda K, Nakajima K, et al
  • Journal Title: Ann Nucl Med Volume: 25 Issue: 8 Pages: 571-9
  • DOI: 10.1007/s12149-011-0504-0
  • NAID: 10030232773
  • Peer Reviewed
• [Journal Article] Incremental prognostic value of myocardial perfusion single photon emission computed tomography for patients with diabetes and chronic kidney disease (2011)
  • Author(s): Okuyama C, Nakajima K, et al
  • Journal Title: Nucl Med Commun Volume: 32 Issue: 10 Pages: 913-9
  • DOI: 10.1097/mnm.0b013e3283495787
  • Peer Reviewed
• [Journal Article] Estimation of cardiac event risk by gated myocardial perfusion imaging and quantitative scoring methods based on a multi-center J-ACCESS database (2010)
  • Author(s): Nakajima K, Matsuo S, Okuda K, Wakabayashi H, Tsukamoto K, Nishimura T
  • Journal Title: Circ J Volume: 75 Pages: 2417-2423
  • NAID: 10029459560
  • Peer Reviewed
• [Journal Article] Normal values for nuclear cardiology: Japanese databases for myocardial perfusion, fatty acid and sympathetic imaging and left ventricular function (2010)
  • Author(s): Nakajima K
  • Journal Title: Ann Nucl Med Volume: 24 Pages: 125-135
  • NAID: 10026390699
• [Journal Article] Identification of myocardial damage in systemic sclerosis: A nuclear cardiology approach. In: Special issue of vascular disease in systemic sclerosis (2010)
  • Author(s): Nakajima K, Matsuo S, Hasegawa M, Kinuya S, Takehara K
  • Journal Title: Int J Rheumatology
  • Peer Reviewed
• [Journal Article] Prognostic value of normal stress myocardial perfusion imaging and ventricular function in Japanese asymptomatic patients with type 2 diabetes (2010)
  • Author(s): Matsuo S, Nakajima K, Yamasaki Y, Kashiwagi A, Nishimura T
  • Journal Title: Circ J Volume: 74 Pages: 1916-1921
  • Peer Reviewed
• [Journal Article] The validity of multi-center common normal database for identifying myocardial ischemia: Japanese Society of Nuclear Medicine working group database (2010)
  • Author(s): Nakajima K, Matsuo S, Kawano M, Matsumoto N, Hashimoto J, Yoshinaga K, Taki J, Okuda K
  • Journal Title: Ann Nucl Med Volume: 24 Pages: 99-105
  • NAID: 10026390646
  • Peer Reviewed
• [Journal Article] Identification of myocardial damage in systemic sclerosis: a nuclear cardiology approach (2010)
  • Author(s): Nakajima K, Matsuo S, et al
  • Journal Title: Int J Rheumatol Volume: doi:10.1155/2010/496509.(web公開) Pages: 1-9
  • NAID: 120002384290
  • Peer Reviewed
• [Presentation] How to establish the database and standard measurements. International Symposium: Understanding the pathophysiology and new treatment for heart disease using nuclear cardiology (2012)
  • Author(s): Nakajima K
  • Organizer: 第52回日本核医学会総会
  • Place of Presentation: ロイトン札幌(北海道)
  • Year and Date: 2012-10-13
• [Presentation] I-123 MIBG meta analysis for predicting cardiac death in heart failure: A multi-center investigation in Japan (2012)
  • Author(s): Nakajima K, Nakata T, Matsuo S, Yamashina S, Kasama S, Yamada T, Momose M, Matsui T, Jacobson A
  • Organizer: 59th Society of Nuclear Medicine Annual Meeting
  • Place of Presentation: Miami Beach Convention Center (USA)
  • Year and Date: 2012-09-13
• [Presentation] Optimization of iterative reconstruction with attenuation, scatter and resolution corrections in myocardial perfusion SPECT/CT (2012)
  • Author(s): Okuda K, Nakajima K, Yamada M, Wakabayashi H, Ichikawa H, Arai H, Matsuo S, Taki J, Kinuya S
  • Organizer: 59th Society of Nuclear Medicine Annual Meeting
  • Place of Presentation: Miami Beach Convention Center (USA)
  • Year and Date: 2012-06-13
• [Presentation] A meta-analysis study for establishing the prognostic efficacy of assessment of cardiac sympathetic innervation assessed by I-123-MIBG imaging in chronic heart failure (2012)
  • Author(s): Nakata T, Nakajima K, Yamashina S†, Kasama S, Yamada T, Momose M, Matsui T,Matsuo S, Travin M, Jacobson A
  • Organizer: 61st Annual Scientific Session of American College of Cardiology
  • Place of Presentation: McCormick Place (USA)
  • Year and Date: 2012-03-27
• [Presentation] Estimation of cardiac event risk based on Japanese multicenter prognostic database using myocardial perfusion imaging (MPI): with reference to diabetes mellitus and chronic kidney disease (2012)
  • Author(s): Nakajima K, Matsuo S, Nishimura S, Yamashina A, Nishimura T.
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2012-03-18
• [Presentation] I-123 MIBG meta analysis for predicting cardiac death in heart failure: A multi-center investigation in Japan. (2012)
  • Author(s): Nakajima K
  • Organizer: Society of Nuclear Medicine Annual Meeting 2012
  • Place of Presentation: Miami Beach Convention Center, Miami Beach, Florida, USA
• [Presentation] How to establish the database and standard measurements - Understanding the pathophysiology and new treatment for heart disease using nuclear cardiology (2012)
  • Author(s): Nakajima K
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: ロイトン札幌、札幌市（北海道）
• [Presentation] 心臓 I-123 MIBGイメージングにおける心縦隔比算出のための半自動アルゴリズム (2011)
  • Author(s): 奥田光一、中嶋憲一、細谷徹夫、石川丈洋、小西貴広、松原孝祐、松尾信郎、絹谷清剛
  • Organizer: 第21回心臓核医学会総会・学術大会
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2011-06-25
• [Presentation] 心筋I-123 MIBG 検査に関する多施設共同研究 (2011)
  • Author(s): 奥田光一、中嶋憲一、桐原ゆみ子、石川丈洋、松尾信郎、滝淳一、絹谷清剛
  • Organizer: ファントム実験および解析結果について日本核医学技術学会.第81回北陸地方会
  • Place of Presentation: 石川県地場産業振興センター(石川県)
  • Year and Date: 2011-06-18
• [Presentation] Myocardial metabolism may offer further risk stratification in the management of patients with heart failure (2011)
  • Author(s): Matsuo S, Nakajima K, Kinuya S
  • Organizer: 58th Annual Meeting of the Society of Nuclear Medicine
  • Place of Presentation: San Antonio Convention Center (USA)
  • Year and Date: 2011-06-08
• [Presentation] Estimation of cardiac event risk by integrated software of perfusion defect scoring and clinical backgrounds International Conference of Nuclear Cardiology and Cardiac CT (2011)
  • Author(s): Nakajima K, Matsuo S, Okuda K, Wakabayashi H, Tsukamoto K, Kinuya S, Nishimura T
  • Organizer: Amsterdam RAI Congress Center
  • Place of Presentation: Netherland
  • Year and Date: 2011-05-18
• [Presentation] Standardization of cardiac meta-iodobenzylguanidine (MIBG) heartto-mediastinum (H/M) ratio for a multi-center studytility of inter-institutional calibration phantomsInternational Conference of Nuclear Cardiology and Cardiac CT (2011)
  • Author(s): Nakajima K, Okuda K, Matsuo S, Kirihara Y, Ishikawa T, Taki J, Yoshita M, Yamada M, Kinuya S
  • Organizer: Amsterdam RAI Congress Center
  • Place of Presentation: Netherland
  • Year and Date: 2011-05-18
• [Presentation] Evaluation of altered myocardial metabolism may be useful in the management of patients heart failure (2011)
  • Author(s): Matsuo S, Nakajima K, Kinuya S
  • Organizer: 10th International Conference of Nuclear CardiologyAmsterdam RAI Congress Center
  • Place of Presentation: Netherland
  • Year and Date: 2011-05-18
• [Presentation] Stress myocardial perfusion imaging for risk stratification of patients with metabolic syndrome: a sub-analysis of the J-ACCESS 2investigation nternational Conference of Nuclear Cardiology and Cardiac CT (2011)
  • Author(s): Takeishi Y, Nakajima K, Nishimura T
  • Organizer: Amsterdam RAI Congress
  • Place of Presentation: Netherland
  • Year and Date: 2011-05-18
• [Presentation] Relationship between stress-induced ischemia and coronary artery atherosclerosis measured by SPECT/CT imaging (2011)
  • Author(s): Matsuo S, Nakajima K, Okuda K, Kinuya S
  • Organizer: 10th International Conference of Nuclear Cardiology
  • Place of Presentation: Amsterdam RAI Congress Center (Netherland)
  • Year and Date: 2011-05-18
• [Presentation] Estimation of cardiac event risk by integrated software of perfusion defect scoring and clinical backgrounds (2011)
  • Author(s): Nakajima K, Matsuo S, et al
  • Organizer: International Conference of Nuclear Cardiology and Cardiac CT
  • Place of Presentation: RAIアムステルダム(ベルギー)
• [Presentation] Stress myocardial perfusion imaging for risk stratification of patients with metabolic syndrome : a sub-analysis of the J-ACCESS 2 investigation (2011)
  • Author(s): Takeishi Y, Nakajima K, et al
  • Organizer: International Conference of Nuclear Cardiology and Cardiac CT
  • Place of Presentation: RAIアムステルダム(ベルギー)
• [Presentation] Relationship between stress-induced ischemia and coronary artery atherosclerosis measured by SPECT/CT imaging (2011)
  • Author(s): Matsuo S, Nakajima K, et al
  • Organizer: International Conference of Nuclear Cardiology and Cardiac CT
  • Place of Presentation: RAIアムステルダム(ベルギー)
• [Presentation] Myocardial metabolism may offer further risk stratification in the management of patients with heart failure (2011)
  • Author(s): Matsuo S, Nakajima K, et al
  • Organizer: 58th Annual Meeting of the Society of Nuclear Medicine
  • Place of Presentation: サンアントニオコンベンションセンター(米国)
• [Presentation] I-123 MIBG心縦隔比の標準化が多施設研究に与える影響 (2011)
  • Author(s): 中嶋憲一、奥田光一, 他
  • Organizer: 第51回日本核医学会学術総会
  • Place of Presentation: つくば国際会議場(茨城県)
• [Presentation] 心筋I-123MIBGイメージングの多施設共同研究におけるコリメータとROI解析方法の影響 (2011)
  • Author(s): 奥田光一、中嶋憲一, 他
  • Organizer: 第51回日本核医学会学術総会
  • Place of Presentation: つくば国際会議場(茨城県)
• [Presentation] 心筋I-123 MIBGイメージングにおける円形心臓ROIの適応 (2010)
  • Author(s): 奥田光一、中嶋憲一、細谷徹夫、石川丈洋、松尾信郎、小西貴広、滝淳一、絹谷清剛
  • Organizer: 第50回日本核医学会学術総会
  • Place of Presentation: 大宮ソニックシティ(埼玉県)
  • Year and Date: 2010-11-13
• [Presentation] I-123MIBGの心縦隔比の標準化:9施設での校正ファントムによる検討 (2010)
  • Author(s): 中嶋憲一、奥田光一、松尾信郎、滝 淳一、絹谷清剛、桐原ゆみ子、石川丈洋
  • Organizer: 第50回日本核医学会学術総会
  • Place of Presentation: 大宮ソニックシティ(埼玉県)
  • Year and Date: 2010-11-13
• [Presentation] 減弱および分解能補正による血流分布への影響 (2010)
  • Author(s): 奥田光一、中嶋憲一、山田正人、荒井弘之、松尾信郎、滝 淳一、絹谷清剛
  • Organizer: 第50回日本核医学会学術総会
  • Place of Presentation: 大宮ソニックシティ(埼玉県)
  • Year and Date: 2010-11-13
• [Presentation] 心筋I-123MIBGの心縦隔比の標準化:9施設での校正ファントムによる検討 (2010)
  • Author(s): 中嶋憲一、奥田光一, 他
  • Organizer: 第50回日本核医学会学術総会
  • Place of Presentation: 大宮ソニックシティ(埼玉県)
  • Year and Date: 2010-11-11
• [Presentation] I-123MIBGイメージングにおける円形心臓ROIの適応 (2010)
  • Author(s): 奥田光一、中嶋憲一, 他
  • Organizer: 第50回日本核医学会学術総会
  • Place of Presentation: 大宮ソニックシティ(埼玉県)
  • Year and Date: 2010-11-11
• [Presentation] 心臓CTによる冠動脈石灰化評価と心筋血流イメージングによる画像診断 (2010)
  • Author(s): 松尾信郎、中嶋憲一, 他
  • Organizer: 第50回日本核医学会学術総会
  • Place of Presentation: 大宮ソニックシティ(埼玉県)
  • Year and Date: 2010-11-11
• [Presentation] 心臓CTと心筋SPECTの融合画像を用いた冠動脈バイパス術後患者の虚血および心筋生存能評価 (2010)
  • Author(s): 松尾信郎、中嶋憲一, 他
  • Organizer: 第50回日本核医学会学術総会
  • Place of Presentation: 大宮ソニックシティ(埼玉県)
  • Year and Date: 2010-11-11
• [Presentation] シンポジウム:「心筋SPECTの標準化に向けて」心臓核医学の標準化に必要な視点 (2010)
  • Author(s): 中嶋憲一
  • Organizer: 第20回心臓核医学会総会・学術大会
  • Place of Presentation: 東京コンファレンスセンター品川(東京都)
  • Year and Date: 2010-06-26
• [Presentation] 心筋SPECTの標準化に向けて心臓核医学の標準化に必要な視点 (2010)
  • Author(s): 中嶋憲一
  • Organizer: 第20回心臓核医学会総会
  • Place of Presentation: 東京コンファレンスセンター(東京都)
  • Year and Date: 2010-06-26
• [Presentation] 心筋MIBG planar画像の心臓ROIに関する検討 (2010)
  • Author(s): 奥田光一、中嶋憲一, 他
  • Organizer: 日本核医学会第71回中部地方会
  • Place of Presentation: 石川県地場産業振興センター(石川県)
  • Year and Date: 2010-06-19
• [Presentation] J-ACCESS 2 multicenter study in Japan (2010)
  • Author(s): Nakajima K, Yamasaki Y, Kusuoka H, Izumi T, Kashiwagi A, Kawamori R, Shimamoto K, Yamada N, Nishimura T
  • Organizer: J-ACCESS 2 multicenter study in Japan: Prognosis of asymptomatic patients with type 2 diabetes Annual Meeting of the Society of Nuclear Medicine 2010
  • Place of Presentation: Salt Palace Convention Center (USA)
  • Year and Date: 2010-06-09
• [Presentation] Prognosis of patients with coronary artery disease after percutaneous coronary intervention: J-ACCESS subanalysis in patients with early revascularization (2010)
  • Author(s): Nakajima K, Matsuo S, Nishimura T
  • Organizer: The 74th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2010-03-07
• [Presentation] Prognostic value of normal stress myocardial perfusion imaging and ventricular function in Japanese asymptomatic patients with type 2 diabetes (2010)
  • Author(s): Matsuo S, Nakajima K, Yamasaki Y, Kashiwagi A, Nishimura T
  • Organizer: The 74th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2010-03-07
• [Book] 核医学画像診断ハンドブック-良い読影と効果的な利用のために- (2011)
  • Author(s): 利波紀久監修、中嶋憲一・絹谷清剛編集
  • Total Pages: 330
  • Publisher: エルゼビア・ジャパン
• [Book] Horizons in World Cardiovascular Research (2010)
  • Author(s): Nakajima K, Nishimura T
  • Publisher: Nova Science
• [Book] Horizons in World Cardiovascular Research Volume 2(第14章)(Prediction of cardiac mortality and events by myocardial perfusion imaging: differences between Japanese and American populations) (2010)
  • Author(s): Nakajima K, Nishimura T
  • Publisher: Nova Science Publishers, Inc.
• [Patent(Industrial Property Rights)] I-123 MIBG 検査の心・縦隔比算出における縦隔関心領域の自動設定方法 (2010)
  • Inventor(s): 中嶋憲一、奥田光一、細谷徹夫、石川丈洋
  • Industrial Property Rights Holder: 富士フイルムRIファーマ株式会社
  • Patent Publication Number: 2012-078088
  • Filing Date: 2010-09-30
• [Patent(Industrial Property Rights)] 画像処理装置、方法、及びコンピュータプログラム (2010)
  • Inventor(s): 中嶋憲一、奥田光一、細谷徹夫、石川丈洋
  • Industrial Property Rights Holder: 金沢大学、富士フィルムRIファーマ株式会社
  • Industrial Property Number: 2010-220474
  • Filing Date: 2010-09-30