In-process control for PET radiopharmaceuticals
| Project/Area Number |
22591350
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Iwate Medical University |
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Principal Investigator |
TERASAKI Kazunori 岩手医科大学, 高エネルギー医学研究部門, 講師 (60285632)
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| Co-Investigator(Kenkyū-buntansha) |
SHOZUSHIMA Masanori 岩手医科大学, 歯科放射線学分野, 教授 (00118259)
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| Co-Investigator(Renkei-kenkyūsha) |
IWATA Ren 東北大学, サイクロトロンラジオアイソトープセンター, 教授 (60143038)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | PE T / 放射性薬剤 / PET / 核薬学 / 分析化学 |
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| Research Abstract |
In process of control was conducted to assure the efficacy and safety for several PET radiopharmaceuticals. By using this technique, the manufacturing process was optimized to keep the amounts of radionuclidic impurities to a m inimum. Significant amounts of radionuclidic impurities from the constitute metal of target chamber were detected in the target water when using a titanium target chamber. However, the impurities were almost completely eliminated subsequent purification or separated process. Solid phase extraction technique for the final formulation gave high -quality injection without impurities over rotary evaporation technique.
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Report
(4 results)
Research Products
(89 results)
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[Journal Article] Accuracy of central benzodiazepine receptor binding potential/cerebral blood flow SPECT imaging for detecting misery perfusion in patients with unilateral major cerebral artery occlusive diseases: comparison with cerebrovascular reactivity to acetazolamide and cerebral blood flow SPECT imagin2012
Author(s)
Kuroda H, Ogasawara K, Suzuki T, Chida K, Aso K, Kobayashi M, Yoshida K, Terasaki K, Fujiwara S, Kubo Y, Ogawa
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Journal Title
Clin Nucl Med
Volume: 37(3)
Pages: 235-240
Related Report
Peer Reviewed
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[Journal Article] Preoperative 123I-iomazenil SPECT imaging predicts cerebral hyperperfusion following endarterectomy for unilateral cervical internal carotid artery stenosis.2012
Author(s)
Ogasawara Y, Ogasawara K, Suzuki T, Yamashita T, Kuroda H, Chida K, Fujiwara S, Aso K, Kobayashi M, Yoshida K, Terasaki K, Ogawa A.
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Journal Title
Am J Nucl Med Mol Imaging.
Volume: 2(1)
Pages: 77-87
Related Report
Peer Reviewed
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[Journal Article] Preoperative central benzodiazepine receptor binding potential and cerebral blood flow images on SPECT predict development of new cerebral ischemic events and cerebral hyperperfusion after carotid endarterectomy.2011
Author(s)
Sato Y, Ogasawara K, Kuroda H, Suzuki T, Chida K, Fujiwara S, Aso K, Kobayashi M, Yoshida K, Terasaki K, Ogawa A.
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Journal Title
J Nucl Med
Volume: 52(9)
Pages: 1400-1407
Related Report
Peer Reviewed
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[Journal Article] 進行性多巣性白質脳症(PML)の脳血流・酸素代謝2011
Author(s)
鈴木真紗子,米澤久司,高橋純子,工藤雅子,小原智子,柴田俊秀,石塚直樹,高橋 智,寺山靖夫,別府高明,樫村博史、小笠原邦昭,佐々木敏秋,寺崎一典,世良耕一郎
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Journal Title
NMCC共同利用研究成果報文集
Volume: 16
Pages: 6-13
Related Report
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