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Regenerative medicine for heart failure in large animal models

Research Project

Project/Area Number 22591557
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology

Principal Investigator

TOYODA Masashi  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究副部長 (50392486)

Co-Investigator(Renkei-kenkyūsha) UMEZAWA Akihiro  独立行政法人国立成育医療研究センター研究所, 再生医療センター, センター長 (70213486)
GOJO Satoshi  京都府立医科大学, 医学研究科, 教授 (90316745)
Research Collaborator ITAKURA Yoko  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (30582746)
KAMI Daisuke  京都府立医科大学, 医学研究科, 助教 (80415588)
MIYOSHI Shunichiro  慶應義塾大学, 医学部, 講師 (10296577)
HIDA Naoko  慶應義塾大学, 医学部, 研究員 (70360112)
INOUE Mayu  独立行政法人国立成育医療研究センター研究所, 生殖・細胞医療研究部, 研究員 (40596920)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords幹細胞 / 細胞移植医療 / トランスレーショナルリサーチ / 大動物モデル / 心疾患 / 細胞移植 / 免疫寛容 / 再生医療 / 疾患モデル / 心不全 / 幹細胞移植 / 間葉系幹細胞 / 疾患モデル動物
Research Abstract

Amniotic membrane contains a multipotential stem cell population. To explore the clinical application of transplantation of allogeneic amniotic membrane stem cells (AMSCs), we transplanted them into porcine hearts affected by chronic myocardial ischemia as a preclinical study. We have demonstrated that allogeneic AMSC transplantation produced histological and functional improvement in the impaired myocardium in a porcine model of chronic myocardial ischemia.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (23 results)

All 2012 2011 2010 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (12 results) Book (3 results) Remarks (1 results)

  • [Journal Article] Allogeneic amniotic membrane-derived mesenchymal stromal cell transplantation in a porcine model of chronic myocardial ischemia.2012

    • Author(s)
      Kimura M, Toyoda M, Gojo S, Itakura Y, Kami D, Miyoshi S, Kyo S, Ono M, Umezawa A.
    • Journal Title

      J. Stem Cells Regen. Med.

      Volume: 8(3) Pages: 171-180

    • URL

      http://www.pubstemcell.com/monthly/vo18iss3.htm

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Placenta to Cartilage: Direct conversion of human placenta to chondrocytes with transformation by defined factors2012

    • Author(s)
      Kami D, Ishii R, Toyoda M, Makino H, Gojo S, Ishii T, Umezawa A
    • Journal Title

      Mol Biol Cell.

      Volume: 23(18) Issue: 18 Pages: 3511-21

    • DOI

      10.1091/mbc.e11-10-0869

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Allogeneic amniotic membrane-derived mesenchymal stromal cell transplantation in a porcine model of chronic myocardial ischemia.2012

    • Author(s)
      Kimura M, Toyoda M et al
    • Journal Title

      J. Stem Cells Regen. Med.

      Volume: 8 Pages: 171-180

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tissue engineering and cell-based therapy toward integrated strategy with artificial organs.2011

    • Author(s)
      Gojo S, Toyoda M, Umezawa A.
    • Journal Title

      J Artif Organs.

      Volume: 14(3) Issue: 3 Pages: 171-177

    • DOI

      10.1007/s10047-011-0578-4

    • NAID

      10030338842

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tissue engineering and cell-based therapy toward integrated strategy with artificial organs2011

    • Author(s)
      Gojo S
    • Journal Title

      J Artif Organs

      Volume: 14 Pages: 171-177

    • NAID

      10030338842

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lectin microarray analysis of pluripotent and multipotent stem cells2011

    • Author(s)
      Toyoda Masashi, et al
    • Journal Title

      Genes to Cells

      Volume: 16 Pages: 1-11

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Defining cell identity by comprehensive gene expression profiling2010

    • Author(s)
      Toyoda Masashi, et al
    • Journal Title

      Curr.Med.Chem.

      Volume: 17 Pages: 3245-3252

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 再生医療の実現化を目指すための幹細胞評価と糖鎖の果たす役割2012

    • Author(s)
      豊田雅土
    • Organizer
      第16回循環器再生医療研究会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Monitoring of the damage to freeze-thawed cells by glycan profiling using a lectin microarray.2012

    • Author(s)
      Itakura Y, Toyoda M et al
    • Organizer
      International Society for Stem Cell Research 10th Annual Meeting.
    • Place of Presentation
      Yokohama
    • Related Report
      2012 Annual Research Report
  • [Presentation] 羊膜細胞を用いた心筋再生医療への取り組み2011

    • Author(s)
      豊田雅士、木村光利、井上-山崎麻由、太田百絵、板倉陽子、上大介、許俊鋭、小野稔、五條理志、梅澤明弘
    • Organizer
      第15回循環器再生医療研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 羊膜細胞を用いた心筋再生医療への取り組み2011

    • Author(s)
      豊田雅士
    • Organizer
      第15回循環器再生医療研究会
    • Place of Presentation
      武田薬品工業東京本社大会議室
    • Year and Date
      2011-11-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] ブタ慢性心筋虚血モデルへの同種ブタ羊膜由来細胞移植.ブタ慢性心筋虚血モデルへの同種ブタ羊膜由来細胞移植2011

    • Author(s)
      木村光利、五條理志、豊田雅士、板倉陽子、許 俊鋭、梅澤明弘、小野 稔
    • Organizer
      第11回心血管再生先端治療フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2011-07-02
    • Related Report
      2012 Final Research Report
  • [Presentation] タ慢性心筋虚血モデルへの同種ブタ羊膜由来細胞移植2011

    • Author(s)
      木村光利
    • Organizer
      第11回心血管再生先端治療フォーラム
    • Place of Presentation
      品川グランドセントラルタワーTHE GRAND HALL
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Transplanted allogenic amniotic membrane-derived mesenchymal cells improved left ventricular function in porcine chronic ischemic heart.2011

    • Author(s)
      Kimura M, Gojo S. Toyoda M. Itakura Y, Miyoshi S, Kyo S, Umezawa A. Ono M.
    • Organizer
      Joint Meeting of 19th ASCVTS & 21^<st> ATCSA
    • Place of Presentation
      Phuket Thailand
    • Year and Date
      2011-05-28
    • Related Report
      2012 Final Research Report
  • [Presentation] ブタ慢性心筋虚血モデルへの同種ブタ羊膜由来細胞移植2011

    • Author(s)
      木村光利、五條理志、豊田雅士、板倉陽子、許俊鋭、三好俊一郎、梅澤明弘、小野稔
    • Organizer
      第10回再生心臓血管外科治療研究会
    • Place of Presentation
      千葉
    • Year and Date
      2011-02-23
    • Related Report
      2012 Final Research Report
  • [Presentation] ブタ慢性心筋虚血モデルにおける同種ブタ羊膜由来細胞移植2011

    • Author(s)
      木村光利、五條理志、豊田雅士、板倉陽子、許俊鋭、西村隆、川島大、梅澤弘、小野稔
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 胎児組織由来細胞の特性と再生医療に向けた取り組み2010

    • Author(s)
      豊田雅士
    • Organizer
      第14回循環器再生医療研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 幹細胞の特性評価と品質管理2010

    • Author(s)
      豊田雅士
    • Organizer
      第13回循環器再生医療研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 再生医療の実現化を目指すための幹細胞評価と糖鎖の果たす役割.

    • Author(s)
      豊田雅士
    • Organizer
      第16回循環器再生医療研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Book] 心筋再生のマテリアル.心不全外科治療の要点と盲点(高本眞一監修,許俊鋭編集)2012

    • Author(s)
      豊田雅士,梅澤明弘
    • Publisher
      文光堂
    • Related Report
      2012 Final Research Report
  • [Book] 心不全外科治療の要点と盲点;心筋再生のマテリアル2012

    • Author(s)
      豊田雅士、梅澤明弘
    • Publisher
      文光堂
    • Related Report
      2012 Annual Research Report
  • [Book] Human Embryonic and Induced Pluripotent Stem Cells2011

    • Author(s)
      Toyoda M
    • Publisher
      Springer
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.tmig.or.jp/J_TMIG/j_research/DA31.html

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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