| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
In our clinical study, we found that local total IgE and antigen (fungi, mites and SEs)-specific IgEs in nasal polyps are related to local eosinophilic inflammation of CRSwNP and AFRS. In our vitro study, we also found that Aspartate proteases from Alternariainduce cytokine production and calcium responsein airway epithelium that is mediated through PAR-2.. Furthermore, we also found that both the epithelium and the infiltrating eosinophils in the ECRS showed significant upregulation of the expression of PAR-2.
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