Elucidation of the pathogenesis and the onset of eosinophilic rhinosinusitis by airborne microorganisms (fungi, Staphylococcus aureus)
| Project/Area Number |
22591904
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKUSHI Tetsushi 東京慈恵会医科大学, 医学部・耳鼻咽喉科 (50317939)
NAKAYAMA Tsuguhisa 東京慈恵会医科大学, 医学部・耳鼻咽喉科 (50408431)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 鼻副鼻腔炎 / 好酸球 / 真菌 / スーパー抗原 / 好酸球性鼻副鼻腔炎 / アレルギー性真菌性鼻副鼻腔炎 / 好酸球性副鼻腔炎 / アレルギー性真菌性副鼻腔炎 / IgE / 鼻茸 / 好酸球炎症 / 黄色ブドウ球菌エンテロトキシン / xylanase / alternaria / アレルギー / サイトカイン / 気道上皮 / 慢性鼻副鼻腔炎 / プロテアーゼ / 黄色ブドウ球菌 / アレルギー性真菌性鼻副鼻腔 |
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| Research Abstract |
In our clinical study, we found that local total IgE and antigen (fungi, mites and SEs)-specific IgEs in nasal polyps are related to local eosinophilic inflammation of CRSwNP and AFRS. In our vitro study, we also found that Aspartate proteases from Alternariainduce cytokine production and calcium responsein airway epithelium that is mediated through PAR-2.. Furthermore, we also found that both the epithelium and the infiltrating eosinophils in the ECRS showed significant upregulation of the expression of PAR-2.
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Report
(4 results)
Research Products
(83 results)
