| Project/Area Number |
22592289
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIURA Akio 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (00106353)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 歯学 / 脳・神経 / 局所麻酔薬 / イオンチャネル / 局所麻酔 / カプサイシン / TRPV1 / カプシエイト / QX-314 |
|---|
| Research Abstract |
The capsaicin/QX-314 group induced longer withdrawal-response latency at 60 to 300 minutes after injection thanthe control. The fluorescence in small- and medium-sized neurons was conspicuous in onlythe dorsal root ganglia injected with capsaicin/QX-314-FAM. These results indicatethat TRPA1 and TRPM8 are ineffective in the transport of QX-314 compared with TRPV1. The capsiate (non-pungent analogue of capsaicin) show the same effects of capsaicin. For this reason, the capsiate may be seen as an alternative to the capsaicin.
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