The role of stress proteins in gastrointestinal and respiratory diseases

• Project/Area Number: 22790072
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Kumamoto University
• Principal Investigator: TANAKA Kenichiro 熊本大学, 大学院・生命科学研究部, 助教 (30555777)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 消化管 / 呼吸器疾患 / ストレス

Research Abstract

Idiopathic pulmonary fibrosis(IPF) is thought to involve inflammatory infiltration of leukocytes, lung injury induced by reactive oxygen species(ROS), in particular superoxide anion, and fibrosis(collagen deposition). Intravenous administration of PC-SOD suppressed the bleomycin-induced increase in the number of leukocytes in bronchoalveolar lavage fluid. Bleomycin-induced collagen deposition and increased hydroxyproline levels in the lung were also suppressed in animals treated with PC-SOD, suggesting that PC-SOD suppresses bleomycin-induced pulmonary fibrosis.

Research Products

• [Journal Article] Stimulation of gastric ulcer healing by heat shock protein 70 (2011)
  • Author(s): Ishihara, T., Suemasu, S., Asano, T., Tanaka, K. and Mizushima, T.
  • Journal Title: Biochem. Pharmacol Volume: 82 Pages: 728-736
  • Peer Reviewed
• [Journal Article] Therapeutic effect of lecithinized superoxide dismutase on pulmonary emphysema (2011)
  • Author(s): Tanaka, K., Tanaka, Y., Miyazaki, Y., Namba, T., Sato, K., Aoshiba, K., Azuma, A. and Mizushima, T.
  • Journal Title: J. Pharmacol. Exp. Ther Volume: 338 Pages: 810-818
  • Peer Reviewed
• [Journal Article] Protective Effect of-β(1, 3-1, 6)-D-glucan against irritant-induced gastric lesions (2011)
  • Author(s): Tanaka, K., Tanaka, Y., Suzuki, T. and Mizushima, T.
  • Journal Title: Br. J. Nutr Volume: 106 Pages: 475-485
  • Peer Reviewed
• [Journal Article] Protective Effect of β-(1,3-1,6)-D-glucan against irritant-induced gastric lesions (2011)
  • Author(s): Tanaka, K., et al
  • Journal Title: Br.J.Nutr. Volume: 106 Pages: 475-485
  • Peer Reviewed
• [Journal Article] Therapeutic effect of lecithinized superoxide dismutase on pulmonary emphysema (2011)
  • Author(s): Tanaka, K., et al
  • Journal Title: J.Pharmacol.Exp.Ther. Volume: 338 Pages: 810-818
  • Peer Reviewed
• [Journal Article] Stimulation of gastric ulcer healing by heat shock protein 70 (2011)
  • Author(s): Ishihara, T., et al
  • Journal Title: Biochem.Pharmacol. Volume: 82 Pages: 728-736
  • Peer Reviewed
• [Journal Article] Therapeutic effect of lecithinized superoxide dismutase(PC-SOD) on bleomycin-induced pulmonary fibrosis (2010)
  • Author(s): Tanaka, K., Ishihara, T., Azuma, A., Kudoh, S., Ebina, M., Nukiwa, T., Sugiyama, Y., Tasaka, Y., Namba, T., Ishihara, T., Sato, K., Mizushima, Y. and Mizushima, T.
  • Journal Title: Am. J. Physiol. Lung Cell. Mol. Physiol Volume: 298
  • Peer Reviewed
• [Journal Article] Heat shock protein 70 protects against bleomycin-induced pulmonary fibrosis in mice (2010)
  • Author(s): Tanaka, K., Tanaka, Y., Namba, T., Azuma, A. and Mizushima, T.
  • Journal Title: Biochem. Pharmacol Volume: 80 Pages: 920-931
  • Peer Reviewed
• [Journal Article] Prevention of ultraviolet B radiation-induced epidermal damage by expression of heat shock protein 70 (2010)
  • Author(s): Matsuda, M., Hoshino, T., Yamashita, Y., Tanaka, K., Maji, D., Sato, K., Adachi, H., Sobue, G., Ihn, H., Funasaka, Y. and Mizushima, T.
  • Journal Title: J. Biol. Chem Volume: 285 Pages: 5848-5858
  • Peer Reviewed
• [Journal Article] Prevention of ultraviolet B radiation-induced epidermal damage by expression of heat shock protein 70. (2010)
  • Author(s): Matsuda.M., et at.
  • Journal Title: J.Biol.Chem. Volume: 285 Pages: 5848-5858
  • Peer Reviewed
• [Journal Article] Therapeutic effect of lecithinized superoxide dismutase (PC-SOD) on bleomycin-induced pulmonary fibrosis. (2010)
  • Author(s): Tanaka.K., et al.
  • Journal Title: Ant.J.Physiol.Lung Cell.Mol.Physiol. Volume: 298
  • Peer Reviewed
• [Journal Article] Heat shock protein 70 protects against bleomycin-induced pulmonary fibrosis in mice. (2010)
  • Author(s): Tanaka.K., et al.
  • Journal Title: Biochem.Pharmacol. Volume: 80 Pages: 920-931
  • Peer Reviewed