The role of stress proteins in gastrointestinal and respiratory diseases
| Project/Area Number |
22790072
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
TANAKA Kenichiro 熊本大学, 大学院・生命科学研究部, 助教 (30555777)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 消化管 / 呼吸器疾患 / ストレス |
|---|
| Research Abstract |
Idiopathic pulmonary fibrosis(IPF) is thought to involve inflammatory infiltration of leukocytes, lung injury induced by reactive oxygen species(ROS), in particular superoxide anion, and fibrosis(collagen deposition). Intravenous administration of PC-SOD suppressed the bleomycin-induced increase in the number of leukocytes in bronchoalveolar lavage fluid. Bleomycin-induced collagen deposition and increased hydroxyproline levels in the lung were also suppressed in animals treated with PC-SOD, suggesting that PC-SOD suppresses bleomycin-induced pulmonary fibrosis.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Therapeutic effect of lecithinized superoxide dismutase on pulmonary emphysema2011
Author(s)
Tanaka, K., Tanaka, Y., Miyazaki, Y., Namba, T., Sato, K., Aoshiba, K., Azuma, A. and Mizushima, T.
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Journal Title
J. Pharmacol. Exp. Ther
Volume: 338
Pages: 810-818
Related Report
Peer Reviewed
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[Journal Article] Therapeutic effect of lecithinized superoxide dismutase(PC-SOD) on bleomycin-induced pulmonary fibrosis2010
Author(s)
Tanaka, K., Ishihara, T., Azuma, A., Kudoh, S., Ebina, M., Nukiwa, T., Sugiyama, Y., Tasaka, Y., Namba, T., Ishihara, T., Sato, K., Mizushima, Y. and Mizushima, T.
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Journal Title
Am. J. Physiol. Lung Cell. Mol. Physiol
Volume: 298
Related Report
Peer Reviewed
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[Journal Article] Prevention of ultraviolet B radiation-induced epidermal damage by expression of heat shock protein 702010
Author(s)
Matsuda, M., Hoshino, T., Yamashita, Y., Tanaka, K., Maji, D., Sato, K., Adachi, H., Sobue, G., Ihn, H., Funasaka, Y. and Mizushima, T.
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Journal Title
J. Biol. Chem
Volume: 285
Pages: 5848-5858
Related Report
Peer Reviewed
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