The serum glycoprotein/peptide analysis for discovery of novel biomarkers of hepatocellular carcinoma.
| Project/Area Number |
22790521
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory medicine
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| Research Institution | Chiba University |
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Principal Investigator |
SOGAWA Kazuyuki 千葉大学, 医学部・附属病院, 寄附研究部門教員 (50436440)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | プロテオミクス / 糖タンパク質 / 糖ペプチド / 原発性肝細胞癌 / レクチンビーズ / MALDI-TOF MS / 二次元電気泳動 / N型糖タンパク質 / N型糖ペプチド / 血清 / プロテオーム解析 |
|---|
| Research Abstract |
Changes in glycosylation, most notably fucosylation, have been associated with the development of hepatocellular carcinoma (HCC). In this report, the levels of growth/differentiation facter 5 (GDF5) was analyzed individually with currently used marker, AFP and PIVKA-II, for the ability to distinguish between a diagnosis of cirrhosis and HCC. This analysis was done on serum from 50 patients with cirrhosis and 50 serum samples from patients with cirrhosis plus HCC. The levels of GDF5 was significantly higher in patients with HCC compared with those with cirrhosis (P<0.01).
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Report
(3 results)
Research Products
(23 results)
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[Patent(Industrial Property Rights)] コフィリンとその自己抗体との複合体の免疫測定方法、それに用いるキットおよびそれを用いた癌判定方法2010
Inventor(s)
曽川一幸, 小島良, 野田健太, 宮崎勝, 吉富秀幸, 高野重紹, 野村文夫, 佐藤守
Industrial Property Rights Holder
曽川一幸, 小島良, 野田健太, 宮崎勝, 吉富秀幸, 高野重紹, 野村文夫, 佐藤守
Filing Date
2010-05-28
Related Report
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