Male contraceptive vaccine using the sperm and the spermatid in mice
| Project/Area Number |
22790572
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Public health/Health science
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 精巣 / 精子形成 / 男性不妊 / 人口爆発 / ワクチン / 避妊ワクチン / 自己免疫 / 精子形成障害 / 自己抗原 / 炎症 / 自己抗体 / 精巣血液関門 / 男性不妊症 / 人口問題 |
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| Research Abstract |
Experimental autoimmune orchitis(EAO) is a model of immunological inflammation demonstrating development of male infertility. We tried to develop the male contraceptive vaccine using murine EAO model induced by the immunization of sperm and spermatid antigens. The results showed that five kinds of protein from candidating 18 genes were adequate for induction of EAO. Moreover, we clarified the pathology of post-active inflammation stage of EAO. These results lead to the development of male contraceptive vaccine.
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Report
(3 results)
Research Products
(43 results)
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[Journal Article] Autologus groin lymph node transfer for lymph network reconstruction after head-and-neck cancer resection and neck lymph node dissection : a case report
Author(s)
Mihara M, Hayashi Y, Iida T, Moriguchi H, Hara H, Yamamoto T, Narushima M, Todokoro T, Uchida G, Hayami S, Sawamoto N, Naito M, Koshima I
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Journal Title
Journal of Plastic, Reconstructive & Aesthetic Surgery
Volume: (in press)
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[Book] スンクスの生物学2011
Author(s)
内藤宗和, 平井宗一, 寺山隼人, 伊藤正裕, 九郎丸正道, 木曽康郎
Publisher
学会出版センター
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