Co-Investigator(Renkei-kenkyūsha) |
OHKAWA Noriaki 富山大学, 大学院医学薬学研究部(医学), 講師 (80416651)
SUZUKI Akinobu 富山大学, 大学院医学薬学研究部(医学), 助教 (40424684)
Shehata Mohammad 富山大学, 大学院医学薬学研究部(医学), 助教 (60444197)
SUZUKI Reiko 富山大学, 大学院医学薬学研究部(医学), 特命助教 (50532404)
NISOZONO Hirofumi 富山大学, 研究推進機構研究推進総合支援センター, 助教 (10502289)
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Budget Amount *help |
¥214,110,000 (Direct Cost: ¥164,700,000、Indirect Cost: ¥49,410,000)
Fiscal Year 2015: ¥45,890,000 (Direct Cost: ¥35,300,000、Indirect Cost: ¥10,590,000)
Fiscal Year 2014: ¥45,890,000 (Direct Cost: ¥35,300,000、Indirect Cost: ¥10,590,000)
Fiscal Year 2013: ¥51,220,000 (Direct Cost: ¥39,400,000、Indirect Cost: ¥11,820,000)
Fiscal Year 2012: ¥39,260,000 (Direct Cost: ¥30,200,000、Indirect Cost: ¥9,060,000)
Fiscal Year 2011: ¥31,850,000 (Direct Cost: ¥24,500,000、Indirect Cost: ¥7,350,000)
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Outline of Final Research Achievements |
In this study, memory update mechanisms were investigated in cell assembly level. We found that, when two distinct units of information interact to generate a new memory, cellular ensembles corresponding to individual memories overlap. Suppressing the overlap neurons inhibits the association between two memories without affecting the initial memories. In addition, optogenetical co-activation of these ensembles creates an artificial memory. These results indicate that overlap in cellular ensembles plays a critical role in memory association.
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