Clinical Utilities of new biomarker for dengue virus infection

• Project/Area Number: 23256004
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Hematology
• Research Institution: Tohoku University
• Principal Investigator: HATTORI Toshio 東北大学, 災害科学国際研究所, 教授 (30172935)
• Co-Investigator(Kenkyū-buntansha): NIKI Toshiro 香川大学, 医学部, 助教 (40558508) ; HIRASHIMA Mitsuomi 香川大学, 医学部, 教授 (70109700) ; HAORILE Chagan-Yasutan 東北大学, 災害科学国際研究所, 助教 (50624821) ; KUBO Toru 長崎大学, 熱帯医学研究所, 研究員 (50444873) ; 児玉 栄一 東北大学, 病院, 助教 (50271151)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥40,430,000 (Direct Cost: ¥31,100,000、Indirect Cost: ¥9,330,000); Fiscal Year 2013: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000); Fiscal Year 2012: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2011: ¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
• Keywords: デングウイルス / デング熱 / デング出血熱 / ガレクチンー９ / オステオポンチン / バイオマーカー / ガレクチン / プロモーター

Outline of Final Research Achievements

Matricellular proteins of galectin-9 (Gal-9) and osteopontin (OPN) were studied in plasma from 65 dengue virus (DENV) infected patients. During the critical phase, Gal-9 levels were significantly higher in DENV infected patients compared to control groups. The highest Gal-9 levels were observed in dengue hemorrhagic fever (DHF) patients (DHF: 2464pg/ml; dengue fever (DF): 1407pg/ml). In the recovery phase, Gal-9 levels significantly declined from peak levels in those patients. Gal-9 levels tracked viral load, and were associated with monocyte frequencies and hematologic variables of coagulation. Plasma levels of OPN were significantly elevated in the critical phase in both of DF and DHF as compared with healthy. During the recovery phase, OPN levels declined while thrombin cleaved OPN levels increased dramatically in both of DF and DHF patients. Thus, Gal-9 and OPN appears to track DENV inflammatory responses and it could serve as an important novel biomarker of acute DENV infection..

Research Products

• [Journal Article] Galectin-9 plasma levels reflect adverse hematological and immunological features in acute dengue virus infection (2013)
  • Author(s): Chagan-Yasutan H1, Ndhlovu LC, Lacuesta TL, Kubo T, Leano PS, Niki T, Oguma S, Morita K, Chew GM, Barbour JD, Telan EF, Hirashima M, Hattori T, Dimaano EM.
  • Journal Title: J Clin Virol Volume: 58(4) Issue: 4 Pages: 635-640
  • DOI: 10.1016/j.jcv.2013.10.022
  • NAID: 120006986004
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Galectin-9 prolongs the survival of septic mice by expanding Tim-3-expressing natural killer T cells and PDCA-1+ CD11c+ macrophages (2013)
  • Author(s): Kadowaki T, Morishita A, Niki T, Hara J, Sato M, Tani J, Miyoshi H, Yoneyama H, Masaki T, Hattori T, Matsukawa A, Hirashima M.
  • Journal Title: Crit Care Volume: 17(6) Issue: 6
  • DOI: 10.1186/cc13147
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cis association of galectin-9 with Tim-3 differentially regulates IL-12/IL-23 expressions in monocytes via TLR signaling (2013)
  • Author(s): Ma CJ1, Li GY, Cheng YQ, Wang JM, Ying RS, Shi L, Wu XY, Niki T, Hirashima M, Li CF, Moorman JP, Yao ZQ
  • Journal Title: PLoS One Volume: 8(8) Issue: 8 Pages: e72488-e72488
  • DOI: 10.1371/journal.pone.0072488
  • Peer Reviewed / Open Access
• [Journal Article] Galectin-9 activates and expands human T-helper 1 cells. (2013)
  • Author(s): Gooden MJ1, Wiersma VR, Samplonius DF, Gerssen J, van Ginkel RJ, Nijman HW, Hirashima M, Niki T, Eggleton P, Helfrich W, Bremer E.
  • Journal Title: PLoS One Volume: 8(5) Issue: 5 Pages: e65616-e65616
  • DOI: 10.1371/journal.pone.0065616
  • Peer Reviewed / Open Access
• [Journal Article] Galectin-9 functionally impairs natural killer cells in humans and mice. (2013)
  • Author(s): Golden-Mason L1, McMahan RH, Strong M, Reisdorph R, Mahaffey S, Palmer BE, Cheng L, Kulesza C, Hirashima M, Niki T, Rosen HR.
  • Journal Title: J Virol Volume: 87(9): Issue: 9 Pages: 4835-4845
  • DOI: 10.1128/jvi.01085-12
  • Peer Reviewed
• [Journal Article] Acyclovir reduces the duration of fever in patients with infectious mononucleosis-like illness. (2013)
  • Author(s): Usami O
  • Journal Title: Tohoku J. Exp. Med. Volume: 229(2) Pages: 137-42
  • Peer Reviewed
• [Journal Article] Rapid Decrease of Plasma Galectin-9 Levels in Patients with Acute HIV Infection after Therapy. (2012)
  • Author(s): Saitoh H
  • Journal Title: Tohoku J. Exp. Med. Volume: 228(2) Pages: 157-61
  • Peer Reviewed
• [Journal Article] Cell surface galectin-9 expressing Th cells regulate Th17 and Foxp3+ Treg development by galectin-9 secretion. (2012)
  • Author(s): Oomizu S, Arikawa T, Niki T, Kadowaki T, Ueno M, Nishi N, Yamauchi A, Hattori T, Masaki T, Hirashima M.
  • Journal Title: PLoS One Volume: 7 Issue: 11 Pages: 1-10
  • DOI: 10.1371/journal.pone.0048574
  • Peer Reviewed
• [Journal Article] Frequent detection of anti-tubercular-glycolipid IgG and IgA antibodies in the healthcare workers with latent tuberculosis infection in the Philippines. (2012)
  • Author(s): Siddiqi UR
  • Journal Title: Clin. Dev. Immunol. Volume: 2012 Pages: 1-10
  • DOI: 10.1155/2012/610707
  • Peer Reviewed
• [Journal Article] Quinolone-induced upregulation of osteopontin gene promoter activity in human lung epithelial cell line A549 (2012)
  • Author(s): Shiratori B
  • Journal Title: Antimicrobial Agents and Chemotherapy Volume: 56 Issue: 6 Pages: 2868-2872
  • DOI: 10.1128/aac.06062-11
  • Peer Reviewed
• [Journal Article] Distinct clinical features in Nontuberculous mycobacterial disease with or without latent tuberculosis infection. (2012)
  • Author(s): Siddiqi UR
  • Journal Title: Tohoku J. Exp. Med . Volume: 226(4) Pages: 313-9
  • Peer Reviewed
• [Journal Article] Frequent detection of anti-tubercular-glycolipid IgG and IgA antibodies in the healthcare workers with latent tuberculosis infection in the Philippines (2012)
  • Author(s): Umme Ruman Siddiqi, Prisca Susan A.Leano, Haorile Yasutan Chagan, Beata Shiratori, Hiroki Saitoh, Yugo Ashino, Yasuhiko Suzuki, Toshio Hattori
  • Journal Title: Clin Dep Immunol Volume: (未定)(in press)
  • Peer Reviewed
• [Journal Article] Elevated anti-tuberculous glycolipid antibody titres in healthy adults and tuberculosis patients in Thailand (2012)
  • Author(s): Siddiqi UR, Punpunich W, Chuchottaworn C, Jindakul S, Ashino Y, Saitoh H, Okada M, Chotpittayasunondh T, Hattori T
  • Journal Title: Int J Tuberc Lung Dis. Volume: (未定)(in press)
  • Peer Reviewed
• [Journal Article] Quinolone-induced up-regulation of osteopontin gene promoter activity in human lung epithelial cell line A549 (2012)
  • Author(s): Beata Shiratori, Jing Zhang, Osamu Usami, Haorile Chagan-Yasutan, Yasuhiko Suzuki, Chie Nakajima, Toshimitsu Uede, Toshio
  • Journal Title: Antimicrobial Agents and Chemotherapy Volume: (未定)(in press)
  • Peer Reviewed
• [Journal Article] Distinct Clinical Features in Nontuberculous Mycobacterial Disease With or Without Latent Tuberculosis Infection (2012)
  • Author(s): Umme Ruman Siddiqi, Haorile Chagan-Yasutan, Chie Nakajima, Hiroki Saitoh, Yugo Ashino, Osamu Usami, Beata Shiratori, Motoki Usuzawa, Yasuhiko
  • Journal Title: Tohoku J.Exp.Med Volume: (未定)(in press)
  • Peer Reviewed
• [Journal Article] Galectin-9 signaling prolongs survival in murine lung-cancer by inducing macrophages to differentiate into plasmacytoid dendritic cell-like macrophages (2012)
  • Author(s): Kadowaki T
  • Journal Title: Clin Immunol Volume: 142(3) Issue: 3 Pages: 296-307
  • DOI: 10.1016/j.clim.2011.11.006
  • Peer Reviewed
• [Journal Article] Galectin-9 ameliorates herpes simplex virus-induced inflammation through apoptosis (2012)
  • Author(s): Shim JA
  • Journal Title: Immunobiology Volume: 217(6) Issue: 6 Pages: 657-66
  • DOI: 10.1016/j.imbio.2011.11.002
  • Peer Reviewed
• [Journal Article] IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma (2012)
  • Author(s): Yang ZZ
  • Journal Title: J Clin Invest Volume: 2;122(4) Issue: 4 Pages: 1271-82
  • DOI: 10.1172/jci59806
  • Peer Reviewed
• [Journal Article] Galectin-9 suppresses Th17 cell development in an IL-2-dependent but Tim-3-independent manner (2012)
  • Author(s): Oomizu S
  • Journal Title: Clin Immunol Volume: 143(1) Issue: 1 Pages: 51-8
  • DOI: 10.1016/j.clim.2012.01.004
  • Peer Reviewed
• [Journal Article] Tim-3 is an inducible human NK cell receptor that enhances interferon gamma production in response to galectin-9 (2012)
  • Author(s): Gleason MK
  • Journal Title: Blood Volume: (印刷中) Issue: 13 Pages: 3064-72
  • DOI: 10.1182/blood-2011-06-360321
  • Peer Reviewed
• [Journal Article] Galectin-9 binding to Tim-3 renders activated human CD4+ T cells less susceptible to HIV-1 infection (2012)
  • Author(s): Shokrollah Elahi, Toshiro Niki, Mitsuomi Hirashima, Helen Horton
  • Journal Title: Blood Volume: (未定)(in press)
  • Peer Reviewed
• [Journal Article] Involvement of osteopntin and its signaling molecule CD44 in clinicopathological features of Adult T cell leukemia (2011)
  • Author(s): Chagan-Yasutan H, Tsukasaki K, Takahashi Y, Oguma S, Harigae H, Ishii N, Zhang J, Fukumoto M, Hattori T
  • Journal Title: Leuk Res. Volume: 35 Pages: 1484-1490
  • Peer Reviewed
• [Journal Article] Epigallocatechin gallate inhibits the HIV reverse transcription step (2011)
  • Author(s): Li S, Hattori T, Kodama EN
  • Journal Title: Antivir Chem Chemother. Volume: 21 Pages: 239-43
  • Peer Reviewed
• [Journal Article] Galection-9 ameliorates acute Graft-versus-host disease through the induction of T-cell apoptosis (2011)
  • Author(s): Sakai K, Ashihara E, Maekawa T, et al
  • Journal Title: Eur J Immunol Volume: 41 Issue: 1 Pages: 67-75
  • DOI: 10.1002/eji.200939931
  • Peer Reviewed
• [Journal Article] Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways (2011)
  • Author(s): Vega-Carrascal I
  • Journal Title: J.Immunol. Volume: 186 Issue: 5 Pages: 2897-2909
  • DOI: 10.4049/jimmunol.1003187
  • Peer Reviewed
• [Journal Article] Endogenous galectin-1 and acute inflammation : emerging notion of a galectin-9 pro-resolving effect (2011)
  • Author(s): Iqbal AJ
  • Journal Title: Am.J.Pathol. Volume: 178 Issue: 3 Pages: 1201-1209
  • DOI: 10.1016/j.ajpath.2010.11.073
  • Peer Reviewed
• [Journal Article] Cutting edge : critical role of intracellular osteopontin in antifungal innate immune responses (2011)
  • Author(s): Inoue M
  • Journal Title: J Immunol Volume: 186 Issue: 1 Pages: 19-23
  • DOI: 10.4049/jimmunol.1002735
  • Peer Reviewed
• [Journal Article] Galectin-9 administration ameliorates CVB3 induced myocarditis by promoting the proliferation of regulatory T cells and alternatively activated Th2 cells (2011)
  • Author(s): Lv K
  • Journal Title: Clin Immunol Volume: 140 Issue: 1 Pages: 92-101
  • DOI: 10.1016/j.clim.2011.03.017
  • Peer Reviewed
• [Journal Article] Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia (2011)
  • Author(s): Zhou Q
  • Journal Title: Blood Volume: 117 Issue: 17 Pages: 4501-4510
  • DOI: 10.1182/blood-2010-10-310425
  • Peer Reviewed
• [Journal Article] Galectin-9 attenuates acute lung injury by expanding CD14-plasmacytoid dendritic cell-like macrophages (2011)
  • Author(s): Kojima K, Arikawa T, Saita N, Goto E, Tsumura S, Tanaka R, Masunaga A, Niki T, Oomizu S, Hirashima M, Kohrogi H
  • Journal Title: Am J Respir Crit Care Med Volume: 184 Pages: 328-339
  • Peer Reviewed
• [Journal Article] Functional characterization of lipopolysaccharide derived from symbiotic bacteria in rice as a macrophage-activating substance (2011)
  • Author(s): Kadowaki T, Inagawa H, Kohchi C, Hirashima M, Soma G
  • Journal Title: Anticancer Res Volume: 31 Pages: 2467-2476
  • Peer Reviewed
• [Journal Article] Influence of galectin-9/Tim-3 interaction on herpes simplex virus-1 latency (2011)
  • Author(s): Reddy PB
  • Journal Title: J Immunol Volume: 187 Issue: 11 Pages: 5745-5755
  • DOI: 10.4049/jimmunol.1102105
  • Peer Reviewed
• [Presentation] Elevation of matricellular proteins in dengue virus infection. (2014)
  • Author(s): Toshio Hattori, Haorile Chagan-Yasutan, Susan Leano, Talitha Lacuesta, Elizabeth Telan.
  • Organizer: 6th ASEAN Congress of Tropical Medicine and Parasitology
  • Place of Presentation: Kuala Lumpur
  • Year and Date: 2014-03-05 – 2014-03-07
• [Presentation] ANALYSIS OF BIOMARKERS IN URINE AND PLASMA OF LEPTOSPIROSIS PATIENTS (2013)
  • Author(s): Firmanto, Delsi Taurustiati, Toshio Hattori, Prisca Susan A. Leano, Freda O. Elizabeth Telan, Haorile Chagan-Yasutan
  • Organizer: 8th Scientific Meeting of International Leptospirosis Society; Fukuoka
  • Place of Presentation: 九州大学
  • Year and Date: 2013-10-08 – 2013-10-13
• [Presentation] デングウイルス感染症におけるオステオポンチンの解析 (2013)
  • Author(s): 浩日勒, 服部俊夫
  • Organizer: 第一回MatriCell フォーラム
  • Place of Presentation: 三重大学
  • Year and Date: 2013-09-07 – 2013-09-08
• [Presentation] デングウイルス感染症による炎症プロファイルを用いた病態のモニタリング (2013)
  • Author(s): 浩日勒, 服部俊夫
  • Organizer: 第67回日本細菌学会東北支部総会
  • Place of Presentation: 仙台
  • Year and Date: 2013-08-30 – 2013-08-31
• [Presentation] Inflammatory Profiles of Dengue Virus Infection. (2013)
  • Author(s): Haorile Chagan-Yasutan, Talitha Lea Lacuesta, Lishomwa C. Ndhlovu, Prisca Susan A. Leano, Elizabeth Freda O.Telan, Toshiro Niki, Mitsuomi Hirashima, Efren M. Dimaano and Toshio Hattori.
  • Organizer: 海外学術調査フェスタ
  • Place of Presentation: 東京外国語大学
  • Year and Date: 2013-06-29
• [Presentation] Profiles of Pro-inflammatory and Anti-inflammatory Cytokine/Chemokines in Acute Dengue Virus Infection. (2013)
  • Author(s): Haorile Chagan-Yasutan, Talitha Lea Lacuesta, Lishomwa C. Ndhlovu, Toru Kubo, Prisca Susan A. Leano, Toshiro Niki, Yugo Ashino, Jason D. Barbour, Elizabeth Freda O. Telan, Mitsuomi Hirashima, Efren M. Dimaano, Toshio Hattori. ,
  • Organizer: NIH-Tohoku University-JSPS International Symposium
  • Place of Presentation: 仙台東北大学
  • Year and Date: 2013-05-09 – 2013-05-10
• [Presentation] Generation of N-half osteopontin in recovery phase of dengue virus infected individuals in Philippines (2013)
  • Author(s): Chagan-Yasutan H,Lacuesta TL,Ndhlovu LC,Leano PSA,Uede T,Telan EFO,Dimaano EM,Hottori T
  • Organizer: Tropical Infectious Diseases, Gordon Research Conference
  • Place of Presentation: Galveston,TX
• [Presentation] Plasma galectin-9 levels reflect disease activity in dengue virus infected patients (2013)
  • Author(s): Hattori T, Chagan-Yasutan H,Lacuesta TL,Ndhlovu LC,Leano PSA,Uede T,Telan EFO,Dimaano EM,
  • Organizer: Tropical Infectious Diseases, Gordon Research Conference
  • Place of Presentation: Galveston,TX
• [Presentation] Surveillance of anti-TBGL antibody in the dengue fever patients (2013)
  • Author(s): Beata Shiratori
  • Organizer: 2nd Conference on Biotec Otsuka Collaborative Research of the Strategic Japanese-Thailand Cooperative Programme
  • Place of Presentation: Bangkok, Thailand
• [Presentation] The generation of immune-modulator lectin-galactin-9 in acute dengue virus infected patients in Philippine (2012)
  • Author(s): Haorile Chagan-Yasutan, Talitha Lea Lacuesta, Susan A.Leano, Umme Ruman Siddiqi, Elizabeth O Telan, Toshio Hattori, Efrren M.Dimaano
  • Organizer: Asian-African Research Forum on Emerging and Reemerging Infections
  • Place of Presentation: 神戸
  • Year and Date: 2012-01-11
• [Presentation] ヒトデングウイルス感染症におけるオステオポンチンの意義 (2012)
  • Author(s): Chagan-Yasutan H 、服部俊夫
  • Organizer: 第114回日本血液学会東北地方会
  • Place of Presentation: 仙台
• [Presentation] Human Security and Disaster Medicine -A brief introduction for new collaborating research and education program in Tohoku University (2012)
  • Author(s): T. Hattori, M. Usuzawa, S. Egawa, H. Tomita, M. Fukumoto, K. Meguro, H. Oshitani, M. Kaku, S. Kushimoto, N. Uehara.
  • Organizer: 8th Research Symposium on Multi-hazards around the Pacific Rim
  • Place of Presentation: Sendai
• [Presentation] Human Security and Disaster Medicine -A brief introduction for new collaborating research and education program in Tohoku University- (2012)
  • Author(s): Shiratori B,Chagan-Yasutan H,Usuzawa M, Leano PSA,Telan EFO,Ashino Y,Suzuki Y,Hottori T
  • Organizer: 8th Research Symposium on Multi-hazards around the Pacific Rim
  • Place of Presentation: Sendai
• [Presentation] Biomarker studies on disaster-related infectious diseases (2012)
  • Author(s): Chagan-YasutH,Ashino Y,Kubo T,Telan EFO,Leano PSA,Siratori B,Usuzawa M,Hattori T
  • Organizer: 8th Research Symposium on Multi-hazards around the Pacific Rim
  • Place of Presentation: Sendai
• [Presentation] Anti-TBGL IgA antibody suggest mucosal immunity involvement in latent tuberculosis in fection,which is frequently positive for anti-TBGL-IgG antibody (2012)
  • Author(s): Haorile Chagan-Yasutan, Lishomwa C. Ndhlovu, Talitha Lea Lacuesta, Prisca Susan A. Leano, Elizabeth Freda O.Telan, Toshiro Niki, Mitsuomi Hirashima, Efren M. Dimaano and Toshio Hattori.
  • Organizer: IMMUNOLOGY 2012
  • Place of Presentation: ボストン, アメリカ
• [Presentation] Networking for AIDS/TB research projects in sub-Sahara Africa-Involvement of mucosal immunity in LTBI (2012)
  • Author(s): Hattori T, Shiratori B, Chagan-Yasutan H, Zhao J, Sizyoongo C, usuzawa M, Usami O, Saitoh H and Ashino Y
  • Organizer: 5th International Research Conference
  • Place of Presentation: イースタンケープ,南アフリカ
• [Presentation] Elevated levels of circulating Galectin-9, a novel immune modulator, in acute Dengue virus refelects disease activity (2012)
  • Author(s): Hattori T, Chagan-Yasutan H
  • Organizer: 14th ASEAN Conference of Clinical Laboratory Sciences
  • Place of Presentation: Manila, Philippines
  • Invited
• [Presentation] Critical role of galectin-9 but not IL-10 from Type1 regulatory T cells to regulate T helper 17 cell development (2011)
  • Author(s): 大水総一, 仁木敏朗, 平島光臣, 他
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 千葉市
  • Year and Date: 2011-11-27
• [Presentation] Galectin-9 switches monocyte differentiation to plasmacytoid dendritic cell-like macrophages to prolong the survival of lung cancer-bearing (2011)
  • Author(s): 門脇健, 仁木敏朗, 平島光臣, 他
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 千葉市
  • Year and Date: 2011-11-27
• [Presentation] The role of osteopontin in infectious diseases (2011)
  • Author(s): 服部俊夫
  • Organizer: The 14th Annual Meeting of Clinical system building of Public health in Yangtze River Delta
  • Place of Presentation: 中国上海
  • Year and Date: 2011-09-23
• [Presentation] 安定化ガレクチン9:抗感染活性を有する免疫正常化因子の開発 (2011)
  • Author(s): 平島光臣
  • Organizer: B型肝炎Reactivationセミナー
  • Place of Presentation: 東京都(招待講演)
  • Year and Date: 2011-09-05
• [Presentation] 安定化ガレクチン9の開発と自己免疫疾患モデルでの有効性 (2011)
  • Author(s): 仁木敏朗
  • Organizer: 国際バイオEXPO(バイオアカデミックフォーラム)
  • Place of Presentation: 東京都
  • Year and Date: 2011-07-01
• [Presentation] Galectin-9 is an important conductor in innate and adaptive immunity (2011)
  • Author(s): 平島光臣
  • Organizer: 第10回オステオポンチン研究会
  • Place of Presentation: 札幌市(招待講演)
  • Year and Date: 2011-06-18
• [Presentation] 4'-Ethynyl-核酸誘導体に対するHIV-1およびHIV-2の耐性機序 (2011)
  • Author(s): 宮本総子, 服部俊夫, 児玉栄一
  • Organizer: 第25回エイズ学会学術集会
  • Place of Presentation: 東京
• [Remarks] デング熱感染症の新規病態マーカーを発見- 危機シグナル分子としてのガレクチン９の役割を提唱
  • URL: http://www.tohoku.ac.jp/japanese/newimg/pressimg/tohokuuniv-press_20131030_01.pdf
• [Remarks] 東北大など、デング熱の新規病態マーカーを発見
  • URL: http://news.mynavi.jp/news/2013/10/31/056/
• [Remarks] 免疫・感染症疾患の新たな制御法開発の可能性
  • URL: http://www.tohoku.ac.jp/japanese/2012/11/press20121108-02.html
• [Patent(Industrial Property Rights)] ジクチオピロン誘導体又はジヒドロジクチオピロン誘導体を有効成分とするオステオポンチン産生阻害剤 (2013)
  • Inventor(s): 服部俊夫
  • Industrial Property Rights Holder: 服部俊夫
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-03-08
  • Acquisition Date: 2015-03-20