Systems engineering approach for colitis remission by use of gut commensal bacteria
| Project/Area Number |
23360373
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | Waseda University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大坂 利文 早稲田大学, 付置研究所, 助教 (70514470)
加川 友己 早稲田大学, 付置研究所, 講師 (90409649)
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| Co-Investigator(Renkei-kenkyūsha) |
OSAKA Toshifumi 早稲田大学, 理工学研究所, 招聘研究員 (70514470)
KAGAWA Yuki 早稲田大学, ナノ理工学研究機構, 研究員 (90409649)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 腸内細菌 / プロバイオティクス / 炎症性疾患 / 代謝産物 / 大腸炎 / メタボローム / 数理モデル / 抗炎症 |
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| Outline of Final Research Achievements |
We identified gut commensal bacteria retaining anti-inflammatory or epithelial tight junction barrier-strengthening properties by in vitro screening. Also, we characterized gut bacteria and metabolites retaining the potential to involve in colitis remission by using a dextran sulfate sodium-induced colitis mouse model. Furthermore, we developed the computational framework for elucidation of stem cell dynamics occurring in colonic crypts and quantitatively prediction of cell behavior.
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Report
(5 results)
Research Products
(20 results)
