Auotoimmune deseases driven with sex difference
| Project/Area Number |
23390429
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
ARAKAKI Rieko 徳島大学, ヘルスバイオサイエンス研究部, 助教 (00193061)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
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| Keywords | 自己免疫疾患 / シェーグレン発症群 / エストロゲン欠乏 / 性差 / 肥満 / シェーグレン症候群 / エストロゲン / 性ホルモン / Th17細胞 / 唾液腺 / Treg細胞 |
|---|
| Research Abstract |
Physiological gender differences in immune system are well recognized and suggested that sex steroid hormones such as estrogen may be involved in the regulation of autoimmunity. We show that estrogen deficiency induces apoptosis of target cells and enhances the inflammatory lesion and Th17 cells in the salivary gland of Sjogrens syndrome (SS) model mice. By the adoptive transfer of cervical lymph node cells from NOD mice (SS model mice) into NOD/scid mice, estrogen deficiency enhances inflammatory lesions in Ovx-NOD/scid mice than Sham-NOD/scid mice. These results show that estrogen deficiency may play a pivotal role for gender-based autoimmunity in postmenopausal women.
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Report
(4 results)
Research Products
(66 results)
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[Journal Article] Fas-Independent T-Cell Apoptosis by Dendritic Cells Controls Autoimmune Arthritis in MRL/lpr Mice2012
Author(s)
Takashi Izawa, Tomoyuki Kondo, Mie Kurosawa, Ritsuko Oura, Kazuma Matsumoto, Eiji Tanaka, Akiko Yamada, Rieko Arakaki, Yasusei Kudo, Yoshio Hayashi and Naozumi Ishimaru
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Journal Title
PLoS ONE
Volume: Vol.7, No.12
Issue: 12
Pages: e48798-e48798
DOI
NAID
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Peer Reviewed
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[Presentation] In vivo effect of multi-wall carbon nanotubes on immune system2013
Author(s)
Yamada Koichi, Akihiko Iwasa, Tomoyuki Kondo, Mie Kurosawa, Rieko Arakaki, Akiko Yamada, Yasusei Kudo, Y Taquahashi, A Takagi, J Kanno and Naozumi Ishimaru
Organizer
6th International Symposium on Nanotechnology,Occupational and Environmental system
Place of Presentation
名古屋国際会議場（ 愛知県名古屋市）
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