Development of drug and gene delivery into brain with ultrasound technologies
| Project/Area Number |
23500567
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Teikyo University |
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Principal Investigator |
SUZUKI Ryo 帝京大学, 薬学部, 准教授 (90384784)
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| Co-Investigator(Renkei-kenkyūsha) |
MARUYAMA Kazuo 帝京大学, 薬学部, 教授 (30130040)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | リポソーム / 脳 / 超音波 / ドラッグデリバリーシステム |
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| Research Abstract |
Recently, some drug and gene therapies for brain disorder have been developed. However, many drugs and genes dropped off from clinical candidates in animal and clinical phase studies because of low efficiency of brain delivery. Therefore, it is necessary to develop effective and non-invasive drug and gene delivery system. To improve this, I developed a novel gene delivery system into brain by the combination of nanobubbles and ultrasound. Our delivery system is the combination of systemic injection of nanobubbles and plasmid DNA and trans-scalp ultrasound exposure to brain. It could express reporter gene in the brain. Therefore, this ultrasound delivery system would be a minimally invasive and brain-selective gene delivery system.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] pDNA-loaded Bubble liposomes as potential ultrasound imaging and gene delivery agents. Biomaterials.2013
Author(s)
Endo-Takahashi Y, Negishi Y, Nakamura A, Suzuki D, Ukai S, Sugimoto K, Moriyasu F, Takagi N, Suzuki R, Maruyama K, Aramaki Y.
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Journal Title
Biomaterials.
Volume: 34
Issue: 11
Pages: 2807-2813
DOI
Related Report
Peer Reviewed
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[Journal Article] Thrombus-targeted perfluorocarbon-containing liposomal bubbles for enhancement of ultrasonic thrombolysis: in vitro and in vivo study.2013
Author(s)
Hagisawa K, Nishioka T, Suzuki R, Maruyama K, Takase B, Ishihara M, Kurita A, Yoshimoto N, Nishida Y, Iida K, Luo H, Siegel RJ.
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Journal Title
J Thromb Haemost.
Volume: 11
Issue: 8
Pages: 1565-1573
DOI
Related Report
Peer Reviewed
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[Journal Article] Prophylactic immunization with Bubble liposomes and ultrasound-treated dendritic 2 cells provided a four-fold decrease in the frequency of melanoma lung metastasis.2012
Author(s)
Oda Y, Suzuki R, Otake S, Nishiie N, Hirata K, Koshima R, Nomura T, Utoguchi N, Kudo N, Tachibana K, Maruyama K
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Journal Title
J Control Release.
Volume: 10:160(2)
Issue: 2
Pages: 362-366
DOI
Related Report
Peer Reviewed
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[Journal Article] CXCL17 expression by tumor cells recruits CD11b+Gr1 high F4/80- cells and promotes tumor progression.2012
Author(s)
Matsui A, Yokoo H, Negishi Y, Endo-Takahashi Y, Chun NA, Kadouchi I, Suzuki R,Maruyama K, Aramaki Y, Semba K, Kobayashi E, Takahashi M, Murakami T.
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Journal Title
PLoS One.
Volume: 7
Issue: 8
Pages: e44080-e44080
DOI
Related Report
Peer Reviewed
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[Journal Article] A facile preparation method of a PFC-containing nano-sized emulsion for theranostics of solid tumors2011
Author(s)
Shiraishi K, Endoh R, Furuhata H, Nishihara M, Suzuki R, Maruyama K, Oda Y, Jo J, Tabata Y, Yamamoto J, Yokoyama M
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Journal Title
Int J Pharm
Volume: 421
Pages: 379-387
Related Report
Peer Reviewed
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